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B3PBR1

- LPXB_CELJU

UniProt

B3PBR1 - LPXB_CELJU

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCJAP498211:GHIT-1124-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:CJA_1125
OrganismiCellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Taxonomic identifieri498211 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeCellvibrio
ProteomesiUP000001036: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthasePRO_1000191469Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi498211.CJA_1125.

Structurei

3D structure databases

ProteinModelPortaliB3PBR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B3PBR1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGHLHIGIV VGEASGDILG AALMTELRRH FPNAEFSGIG GPRMLELGFH
60 70 80 90 100
SYFPQDRLAV MGLIEPLKRL PELLRIRKFL REHFTANPPS VFIGIDSPDF
110 120 130 140 150
TIPLEGALKE KGIKTVHYVS PSVWAWRQKR IINIARSVDL MLTLLPFEAR
160 170 180 190 200
FYEEHGVPVE FVGHHLADAI PDNVDKTAAR QLLGLPGQGR IVALLPGSRS
210 220 230 240 250
SEVERMAELF FRTAVFCIEQ DPSLHFVVPA ANSDRYRQLH IELNDFVDFP
260 270 280 290 300
IHLVNGHSQD AMAAADVLLV ASGTVTLEAL LLKKPMVVAY KMAPLTYRIL
310 320 330 340 350
SWLVKTPFVS LPNLLAQKML VPELLQDKAT PEALSAAVMN YFENPEQSMA
360 370 380
VSQTFADMHR ELKCNASARA ADAIARLIKP AEAS
Length:384
Mass (Da):42,567
Last modified:September 2, 2008 - v1
Checksum:i8DAF460DD7BD1407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000934 Genomic DNA. Translation: ACE85917.1.
RefSeqiYP_001981621.1. NC_010995.1.

Genome annotation databases

EnsemblBacteriaiACE85917; ACE85917; CJA_1125.
GeneIDi6413976.
KEGGicja:CJA_1125.
PATRICi21325639. VBICelJap122165_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000934 Genomic DNA. Translation: ACE85917.1 .
RefSeqi YP_001981621.1. NC_010995.1.

3D structure databases

ProteinModelPortali B3PBR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498211.CJA_1125.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE85917 ; ACE85917 ; CJA_1125 .
GeneIDi 6413976.
KEGGi cja:CJA_1125.
PATRICi 21325639. VBICelJap122165_1113.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CJAP498211:GHIT-1124-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Insights into plant cell wall degradation from the genome sequence of the soil bacterium Cellvibrio japonicus."
    DeBoy R.T., Mongodin E.F., Fouts D.E., Tailford L.E., Khouri H., Emerson J.B., Mohamoud Y., Watkins K., Henrissat B., Gilbert H.J., Nelson K.E.
    J. Bacteriol. 190:5455-5463(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ueda107.

Entry informationi

Entry nameiLPXB_CELJU
AccessioniPrimary (citable) accession number: B3PBR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3