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B3P9N0

- PGAM5_DROER

UniProt

B3P9N0 - PGAM5_DROER

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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homologBy similarity
Gene namesi
Name:Pgam5By similarity
ORF Names:GG12675
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0104963. Dere\GG12675.

Subcellular locationi

Mitochondrion outer membrane By similaritySequence Analysis; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390704Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliB3P9N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK15637.
OrthoDBiEOG7966H1.
PhylomeDBiB3P9N0.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

B3P9N0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKLTSFVCG TGAGLAVYYL QRLRDPQATV NNSWTNSEKP VDPWALWDTN
60 70 80 90 100
WDCREPRALV RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV
110 120 130 140 150
GDSDDTHHLT ERGRKQAEFT GKRLCELGIK WDKVVASTMV RAQETSDIIL
160 170 180 190 200
KQIDFEKEKV VNCAFLREGA PIPPQPPVGH WKPEASQFLR DGSRIEAAFR
210 220 230 240 250
RYFYRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW LRISINHASI
260 270 280
TWLTISPSGN VSIKYLGDSG FMPAELLTHR IPRDAKNVV
Length:289
Mass (Da):33,151
Last modified:September 2, 2008 - v1
Checksum:i324AED21AA10ABB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954183 Genomic DNA. Translation: EDV45526.1.
RefSeqiXP_001982557.1. XM_001982521.1.

Genome annotation databases

EnsemblMetazoaiFBtr0132729; FBpp0131221; FBgn0104963.
GeneIDi6555713.
KEGGider:Dere_GG12675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954183 Genomic DNA. Translation: EDV45526.1 .
RefSeqi XP_001982557.1. XM_001982521.1.

3D structure databases

ProteinModelPortali B3P9N0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0132729 ; FBpp0131221 ; FBgn0104963 .
GeneIDi 6555713.
KEGGi der:Dere_GG12675.

Organism-specific databases

FlyBasei FBgn0104963. Dere\GG12675.

Phylogenomic databases

KOi K15637.
OrthoDBi EOG7966H1.
PhylomeDBi B3P9N0.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01Imported.

Entry informationi

Entry nameiPGAM5_DROER
AccessioniPrimary (citable) accession number: B3P9N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3