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B3P3K2

- PDE6_DROER

UniProt

B3P3K2 - PDE6_DROER

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei731 – 7311Proton donorBy similarity
Metal bindingi735 – 7351Divalent metal cation 1By similarity
Metal bindingi771 – 7711Divalent metal cation 1By similarity
Metal bindingi772 – 7721Divalent metal cation 1By similarity
Metal bindingi772 – 7721Divalent metal cation 2By similarity
Metal bindingi882 – 8821Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GG21262
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0113442. Dere\GG21262.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11281128cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363686Add
BLAST
Propeptidei1129 – 11313Removed in mature formBy similarityPRO_0000363687

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1128 – 11281Cysteine methyl esterBy similarity
Lipidationi1128 – 11281S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliB3P3K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 412158GAF 1Sequence AnalysisAdd
BLAST
Domaini444 – 625182GAF 2Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB3P3K2.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3P3K2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVSSPAGG AASPVEMATS SSSAATTLTN GANKTAISTA AGVAPGAVPG
60 70 80 90 100
PGSAAIPASS SSGNQVKLEH HHRQSNNNRP AATNRSSETK LRSPAGESDG
110 120 130 140 150
ASRLMTPAGS SSTPSQSPSP SQSPSQASIQ TQTSQQDRLA KASTTASQQD
160 170 180 190 200
VDEVARLFEE KPEAFEKWLT ERAPPEALSR LQEFIENRKP HKRPSVTSDL
210 220 230 240 250
FQQWMAASPT VQQKSPRSLS NSSASSIPEC RRHLMDLDEG ELFMELIRDV
260 270 280 290 300
ANELDIDVLC HKILVNVGLL THADRGSLFL AKGTPTNKYL VAKLFDVTQK
310 320 330 340 350
TALKDAVTRA SAEEIIIPFG IGIAGMVAQT KQMINIKEAY KDARFNCEID
360 370 380 390 400
LKTGYKTNAI LCMPICNYEG DIIGVAQIIN KTNGGCFKGC MEFDEHDVEI
410 420 430 440 450
FRRYLTFCGI GIQNAQLFEM SVQEYRRNQI LLNLARSIFE EQNNLECLVT
460 470 480 490 500
KIMTEARELL KCERCSVFLV DLDCCEASHL EKIIEKPNQP ATRAIKSADS
510 520 530 540 550
FEEKKMRNRF TVLFELGGEY QAANVSRPSV SELSSSTLAQ IAQFVATTGQ
560 570 580 590 600
TVNICDVIEW VRDHNQIRAE DEIDSTQAIL CMPIMNAQKK VIGVAQLINK
610 620 630 640 650
ANGVPFTDSD ASIFEAFAIF CGLGIHNTQM YENACKLMAK QKVALECLSY
660 670 680 690 700
HATASQDQTE KLTQDVIAEA ESYNLYSFTF TDFELVDDDT CRAVLRMFMQ
710 720 730 740 750
CNLVSQFQIP YDVLCRWVLS VRKNYRPVKY HNWRHALNVA QTMFAMLKTG
760 770 780 790 800
KMERFMTDLE ILGLLVACLC HDLDHRGTNN AFQTKTESPL AILYTTSTME
810 820 830 840 850
HHHFDQCVMI LNSEGNNIFQ ALSPEDYRSV MKTVESAILS TDLAMYFKKR
860 870 880 890 900
NAFLELVENG EFDWQGEEKK DLLCGMMMTA CDVSAIAKPW EVQHKVAKLV
910 920 930 940 950
ADEFFDQGDL EKLQLNTQPV AMMDRERKDE LPKMQVGFID VICLPLYRVL
960 970 980 990 1000
CDTFPWITPL YEGTLENRRN WQDLAEKVEM GLTWIDHDTI DKPVEEFAAC
1010 1020 1030 1040 1050
ADEEIKDIEF TVTTLNCNQQ SQHGSEDSHT PEHQRSGSRL SMKKTGALGK
1060 1070 1080 1090 1100
AVRSKLSKTL YNSMDGSKPK TSLKLLESHV SEDMDDKSPT SPSQPQASGS
1110 1120 1130
MGRMSASSST SSAGGQMVDK SKKRSKLCAL L
Length:1,131
Mass (Da):125,578
Last modified:September 2, 2008 - v1
Checksum:iD63B518C430CAE35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV48890.1.
RefSeqiXP_001979932.1. XM_001979896.1.

Genome annotation databases

EnsemblMetazoaiFBtr0141316; FBpp0139808; FBgn0113442.
GeneIDi6552139.
KEGGider:Dere_GG21262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV48890.1 .
RefSeqi XP_001979932.1. XM_001979896.1.

3D structure databases

ProteinModelPortali B3P3K2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0141316 ; FBpp0139808 ; FBgn0113442 .
GeneIDi 6552139.
KEGGi der:Dere_GG21262.

Organism-specific databases

FlyBasei FBgn0113442. Dere\GG21262.

Phylogenomic databases

KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B3P3K2.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01Imported.

Entry informationi

Entry nameiPDE6_DROER
AccessioniPrimary (citable) accession number: B3P3K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 2, 2008
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3