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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei731Proton donorBy similarity1
Metal bindingi735Divalent metal cation 1By similarity1
Metal bindingi771Divalent metal cation 1By similarity1
Metal bindingi772Divalent metal cation 1By similarity1
Metal bindingi772Divalent metal cation 2By similarity1
Metal bindingi882Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GG21262
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008711 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0113442. Dere\GG21262.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003636861 – 1128cGMP-specific 3',5'-cyclic phosphodiesteraseAdd BLAST1128
PropeptideiPRO_00003636871129 – 1131Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1128Cysteine methyl esterBy similarity1
Lipidationi1128S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliB3P3K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 412GAF 1Sequence analysisAdd BLAST158
Domaini444 – 625GAF 2Sequence analysisAdd BLAST182

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence analysis
Contains 2 GAF domains.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OMAiLDCCEAS.
OrthoDBiEOG091G04JU.
PhylomeDBiB3P3K2.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3P3K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVSSPAGG AASPVEMATS SSSAATTLTN GANKTAISTA AGVAPGAVPG
60 70 80 90 100
PGSAAIPASS SSGNQVKLEH HHRQSNNNRP AATNRSSETK LRSPAGESDG
110 120 130 140 150
ASRLMTPAGS SSTPSQSPSP SQSPSQASIQ TQTSQQDRLA KASTTASQQD
160 170 180 190 200
VDEVARLFEE KPEAFEKWLT ERAPPEALSR LQEFIENRKP HKRPSVTSDL
210 220 230 240 250
FQQWMAASPT VQQKSPRSLS NSSASSIPEC RRHLMDLDEG ELFMELIRDV
260 270 280 290 300
ANELDIDVLC HKILVNVGLL THADRGSLFL AKGTPTNKYL VAKLFDVTQK
310 320 330 340 350
TALKDAVTRA SAEEIIIPFG IGIAGMVAQT KQMINIKEAY KDARFNCEID
360 370 380 390 400
LKTGYKTNAI LCMPICNYEG DIIGVAQIIN KTNGGCFKGC MEFDEHDVEI
410 420 430 440 450
FRRYLTFCGI GIQNAQLFEM SVQEYRRNQI LLNLARSIFE EQNNLECLVT
460 470 480 490 500
KIMTEARELL KCERCSVFLV DLDCCEASHL EKIIEKPNQP ATRAIKSADS
510 520 530 540 550
FEEKKMRNRF TVLFELGGEY QAANVSRPSV SELSSSTLAQ IAQFVATTGQ
560 570 580 590 600
TVNICDVIEW VRDHNQIRAE DEIDSTQAIL CMPIMNAQKK VIGVAQLINK
610 620 630 640 650
ANGVPFTDSD ASIFEAFAIF CGLGIHNTQM YENACKLMAK QKVALECLSY
660 670 680 690 700
HATASQDQTE KLTQDVIAEA ESYNLYSFTF TDFELVDDDT CRAVLRMFMQ
710 720 730 740 750
CNLVSQFQIP YDVLCRWVLS VRKNYRPVKY HNWRHALNVA QTMFAMLKTG
760 770 780 790 800
KMERFMTDLE ILGLLVACLC HDLDHRGTNN AFQTKTESPL AILYTTSTME
810 820 830 840 850
HHHFDQCVMI LNSEGNNIFQ ALSPEDYRSV MKTVESAILS TDLAMYFKKR
860 870 880 890 900
NAFLELVENG EFDWQGEEKK DLLCGMMMTA CDVSAIAKPW EVQHKVAKLV
910 920 930 940 950
ADEFFDQGDL EKLQLNTQPV AMMDRERKDE LPKMQVGFID VICLPLYRVL
960 970 980 990 1000
CDTFPWITPL YEGTLENRRN WQDLAEKVEM GLTWIDHDTI DKPVEEFAAC
1010 1020 1030 1040 1050
ADEEIKDIEF TVTTLNCNQQ SQHGSEDSHT PEHQRSGSRL SMKKTGALGK
1060 1070 1080 1090 1100
AVRSKLSKTL YNSMDGSKPK TSLKLLESHV SEDMDDKSPT SPSQPQASGS
1110 1120 1130
MGRMSASSST SSAGGQMVDK SKKRSKLCAL L
Length:1,131
Mass (Da):125,578
Last modified:September 2, 2008 - v1
Checksum:iD63B518C430CAE35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV48890.1.
RefSeqiXP_001979932.2. XM_001979896.2.

Genome annotation databases

EnsemblMetazoaiFBtr0141316; FBpp0139808; FBgn0113442.
GeneIDi6552139.
KEGGider:Dere_GG21262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV48890.1.
RefSeqiXP_001979932.2. XM_001979896.2.

3D structure databases

ProteinModelPortaliB3P3K2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0141316; FBpp0139808; FBgn0113442.
GeneIDi6552139.
KEGGider:Dere_GG21262.

Organism-specific databases

FlyBaseiFBgn0113442. Dere\GG21262.

Phylogenomic databases

KOiK13763.
OMAiLDCCEAS.
OrthoDBiEOG091G04JU.
PhylomeDBiB3P3K2.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDE6_DROER
AccessioniPrimary (citable) accession number: B3P3K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.