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B3P3K2

- PDE6_DROER

UniProt

B3P3K2 - PDE6_DROER

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Protein
cGMP-specific 3',5'-cyclic phosphodiesterase
Gene
Pde6, GG21262
Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei731 – 7311Proton donor By similarity
Metal bindingi735 – 7351Divalent metal cation 1 By similarity
Metal bindingi771 – 7711Divalent metal cation 1 By similarity
Metal bindingi772 – 7721Divalent metal cation 1 By similarity
Metal bindingi772 – 7721Divalent metal cation 2 By similarity
Metal bindingi882 – 8821Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GG21262
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0113442. Dere\GG21262.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11281128cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity
PRO_0000363686Add
BLAST
Propeptidei1129 – 11313Removed in mature form By similarityBy similarity
PRO_0000363687

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1128 – 11281Cysteine methyl ester By similarityBy similarity
Lipidationi1128 – 11281S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB3P3K2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 412158GAF 1
Add
BLAST
Domaini444 – 625182GAF 2
Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB3P3K2.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3P3K2-1 [UniParc]FASTAAdd to Basket

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MTDVSSPAGG AASPVEMATS SSSAATTLTN GANKTAISTA AGVAPGAVPG     50
PGSAAIPASS SSGNQVKLEH HHRQSNNNRP AATNRSSETK LRSPAGESDG 100
ASRLMTPAGS SSTPSQSPSP SQSPSQASIQ TQTSQQDRLA KASTTASQQD 150
VDEVARLFEE KPEAFEKWLT ERAPPEALSR LQEFIENRKP HKRPSVTSDL 200
FQQWMAASPT VQQKSPRSLS NSSASSIPEC RRHLMDLDEG ELFMELIRDV 250
ANELDIDVLC HKILVNVGLL THADRGSLFL AKGTPTNKYL VAKLFDVTQK 300
TALKDAVTRA SAEEIIIPFG IGIAGMVAQT KQMINIKEAY KDARFNCEID 350
LKTGYKTNAI LCMPICNYEG DIIGVAQIIN KTNGGCFKGC MEFDEHDVEI 400
FRRYLTFCGI GIQNAQLFEM SVQEYRRNQI LLNLARSIFE EQNNLECLVT 450
KIMTEARELL KCERCSVFLV DLDCCEASHL EKIIEKPNQP ATRAIKSADS 500
FEEKKMRNRF TVLFELGGEY QAANVSRPSV SELSSSTLAQ IAQFVATTGQ 550
TVNICDVIEW VRDHNQIRAE DEIDSTQAIL CMPIMNAQKK VIGVAQLINK 600
ANGVPFTDSD ASIFEAFAIF CGLGIHNTQM YENACKLMAK QKVALECLSY 650
HATASQDQTE KLTQDVIAEA ESYNLYSFTF TDFELVDDDT CRAVLRMFMQ 700
CNLVSQFQIP YDVLCRWVLS VRKNYRPVKY HNWRHALNVA QTMFAMLKTG 750
KMERFMTDLE ILGLLVACLC HDLDHRGTNN AFQTKTESPL AILYTTSTME 800
HHHFDQCVMI LNSEGNNIFQ ALSPEDYRSV MKTVESAILS TDLAMYFKKR 850
NAFLELVENG EFDWQGEEKK DLLCGMMMTA CDVSAIAKPW EVQHKVAKLV 900
ADEFFDQGDL EKLQLNTQPV AMMDRERKDE LPKMQVGFID VICLPLYRVL 950
CDTFPWITPL YEGTLENRRN WQDLAEKVEM GLTWIDHDTI DKPVEEFAAC 1000
ADEEIKDIEF TVTTLNCNQQ SQHGSEDSHT PEHQRSGSRL SMKKTGALGK 1050
AVRSKLSKTL YNSMDGSKPK TSLKLLESHV SEDMDDKSPT SPSQPQASGS 1100
MGRMSASSST SSAGGQMVDK SKKRSKLCAL L 1131
Length:1,131
Mass (Da):125,578
Last modified:September 2, 2008 - v1
Checksum:iD63B518C430CAE35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954181 Genomic DNA. Translation: EDV48890.1.
RefSeqiXP_001979932.1. XM_001979896.1.

Genome annotation databases

EnsemblMetazoaiFBtr0141316; FBpp0139808; FBgn0113442.
GeneIDi6552139.
KEGGider:Dere_GG21262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954181 Genomic DNA. Translation: EDV48890.1 .
RefSeqi XP_001979932.1. XM_001979896.1.

3D structure databases

ProteinModelPortali B3P3K2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0141316 ; FBpp0139808 ; FBgn0113442 .
GeneIDi 6552139.
KEGGi der:Dere_GG21262.

Organism-specific databases

FlyBasei FBgn0113442. Dere\GG21262.

Phylogenomic databases

KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B3P3K2.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiPDE6_DROER
AccessioniPrimary (citable) accession number: B3P3K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi