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B3P3K2

- PDE6_DROER

UniProt

B3P3K2 - PDE6_DROER

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei731 – 7311Proton donorBy similarity
    Metal bindingi735 – 7351Divalent metal cation 1By similarity
    Metal bindingi771 – 7711Divalent metal cation 1By similarity
    Metal bindingi772 – 7721Divalent metal cation 1By similarity
    Metal bindingi772 – 7721Divalent metal cation 2By similarity
    Metal bindingi882 – 8821Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GG21262
    OrganismiDrosophila erecta (Fruit fly)
    Taxonomic identifieri7220 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008711: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0113442. Dere\GG21262.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11281128cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363686Add
    BLAST
    Propeptidei1129 – 11313Removed in mature formBy similarityPRO_0000363687

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1128 – 11281Cysteine methyl esterBy similarity
    Lipidationi1128 – 11281S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB3P3K2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini255 – 412158GAF 1Sequence AnalysisAdd
    BLAST
    Domaini444 – 625182GAF 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    KOiK13763.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB3P3K2.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B3P3K2-1 [UniParc]FASTAAdd to Basket

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    MTDVSSPAGG AASPVEMATS SSSAATTLTN GANKTAISTA AGVAPGAVPG     50
    PGSAAIPASS SSGNQVKLEH HHRQSNNNRP AATNRSSETK LRSPAGESDG 100
    ASRLMTPAGS SSTPSQSPSP SQSPSQASIQ TQTSQQDRLA KASTTASQQD 150
    VDEVARLFEE KPEAFEKWLT ERAPPEALSR LQEFIENRKP HKRPSVTSDL 200
    FQQWMAASPT VQQKSPRSLS NSSASSIPEC RRHLMDLDEG ELFMELIRDV 250
    ANELDIDVLC HKILVNVGLL THADRGSLFL AKGTPTNKYL VAKLFDVTQK 300
    TALKDAVTRA SAEEIIIPFG IGIAGMVAQT KQMINIKEAY KDARFNCEID 350
    LKTGYKTNAI LCMPICNYEG DIIGVAQIIN KTNGGCFKGC MEFDEHDVEI 400
    FRRYLTFCGI GIQNAQLFEM SVQEYRRNQI LLNLARSIFE EQNNLECLVT 450
    KIMTEARELL KCERCSVFLV DLDCCEASHL EKIIEKPNQP ATRAIKSADS 500
    FEEKKMRNRF TVLFELGGEY QAANVSRPSV SELSSSTLAQ IAQFVATTGQ 550
    TVNICDVIEW VRDHNQIRAE DEIDSTQAIL CMPIMNAQKK VIGVAQLINK 600
    ANGVPFTDSD ASIFEAFAIF CGLGIHNTQM YENACKLMAK QKVALECLSY 650
    HATASQDQTE KLTQDVIAEA ESYNLYSFTF TDFELVDDDT CRAVLRMFMQ 700
    CNLVSQFQIP YDVLCRWVLS VRKNYRPVKY HNWRHALNVA QTMFAMLKTG 750
    KMERFMTDLE ILGLLVACLC HDLDHRGTNN AFQTKTESPL AILYTTSTME 800
    HHHFDQCVMI LNSEGNNIFQ ALSPEDYRSV MKTVESAILS TDLAMYFKKR 850
    NAFLELVENG EFDWQGEEKK DLLCGMMMTA CDVSAIAKPW EVQHKVAKLV 900
    ADEFFDQGDL EKLQLNTQPV AMMDRERKDE LPKMQVGFID VICLPLYRVL 950
    CDTFPWITPL YEGTLENRRN WQDLAEKVEM GLTWIDHDTI DKPVEEFAAC 1000
    ADEEIKDIEF TVTTLNCNQQ SQHGSEDSHT PEHQRSGSRL SMKKTGALGK 1050
    AVRSKLSKTL YNSMDGSKPK TSLKLLESHV SEDMDDKSPT SPSQPQASGS 1100
    MGRMSASSST SSAGGQMVDK SKKRSKLCAL L 1131
    Length:1,131
    Mass (Da):125,578
    Last modified:September 2, 2008 - v1
    Checksum:iD63B518C430CAE35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954181 Genomic DNA. Translation: EDV48890.1.
    RefSeqiXP_001979932.1. XM_001979896.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0141316; FBpp0139808; FBgn0113442.
    GeneIDi6552139.
    KEGGider:Dere_GG21262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954181 Genomic DNA. Translation: EDV48890.1 .
    RefSeqi XP_001979932.1. XM_001979896.1.

    3D structure databases

    ProteinModelPortali B3P3K2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0141316 ; FBpp0139808 ; FBgn0113442 .
    GeneIDi 6552139.
    KEGGi der:Dere_GG21262.

    Organism-specific databases

    FlyBasei FBgn0113442. Dere\GG21262.

    Phylogenomic databases

    KOi K13763.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B3P3K2.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14021-0224.01Imported.

    Entry informationi

    Entry nameiPDE6_DROER
    AccessioniPrimary (citable) accession number: B3P3K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3