B3P2E0 (B3P2E0_DROER) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histone deacetylase PIRNR PIRNR037913
EC=3.5.1.98 PIRNR PIRNR037913

Gene names

Name:	GG10995 FlyBase FBgn0103297
Synonyms:	Dere\GG10995 EMBL EDV47890.1
ORF Names:	Dere_GG10995 EMBL EDV47890.1

Organism

Drosophila erecta (Fruit fly) [Complete proteome]

Taxonomic identifier

7220 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913
Subcellular location	Nucleus By similarity PIRNR PIRNR037913.
Sequence similarities	Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
Biological process	Transcription Transcription regulation PIRNR PIRNR037913
Cellular component	Nucleus PIRNR PIRNR037913
Molecular function	Chromatin regulator PIRNR PIRNR037913 Hydrolase PIRNR PIRNR037913 SAAS SAAS000286
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histone H3 deacetylation Inferred from electronic annotation. Source: GOC histone H4 deacetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K18 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3P2E0 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: EAE7D8A0687DB8B7	FASTA	438	49,688
	10 20 30 40 50 60 MTDRRVSYFY NADVGNFHYG AGHPMKPQRL AVTHSLVMNY GLHKKMKIYR PYKASAQDML 70 80 90 100 110 120 RFHSDEYIAY LQQVTPQNIQ CNSVAYTKYL AHFSVGEDCP VFDGLFDFCA MYTGASLEGA 130 140 150 160 170 180 QKLNHNHSDI CINWSGGLHH AKKFEASGFC YVNDIVIGIL ELLKYHPRVL YIDIDVHHGD 190 200 210 220 230 240 GVQEAFYLTD RVMTASFHKY GNYFFPGTGD MYEIGAESGR YYSVNVPLKE GIDDQSYFQV 250 260 270 280 290 300 FKPIISAIMD FYRPTAIVLQ CGADSLAGDR LGCFSLSTKG HGECVKFVKE LNVPTLVVGG 310 320 330 340 350 360 GGYTLRNVAR CWTHETSLLV DQDIENDLPA TEYYDFFAPD FTLHPEINSR QDNANSKQYL 370 380 390 400 410 420 ELIVKHVYEN LKMCQHSPSV QMVQTPPDVD LEELRNNREE ASDPDVRMSV ADEDKIVDAK 430 NEFYDGDQDQ DKPDSAES

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 14021-0224.01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH954181 Genomic DNA. Translation: EDV47890.1.
RefSeq	XP_001978932.1. XM_001978896.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0131049; FBpp0129541; FBgn0103297.
GeneID	6552202.
KEGG	der:Dere_GG10995.
Organism-specific databases
FlyBase	FBgn0103297. Dere\GG10995.
Phylogenomic databases
KO	K11404.
OrthoDB	EOG4TB2SH.
Family and domain databases
Gene3D	3.40.800.20. 1 hit.
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
PANTHER	PTHR10625. PTHR10625. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

B3P2E0_DROER

Accession

Primary (citable) accession number: B3P2E0

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)