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Protein

DNA ligase

Gene

Dere\GG17130

Organism
Drosophila erecta (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dere\GG17130Imported
ORF Names:Dere_GG17130Imported, GG17130Imported
OrganismiDrosophila erecta (Fruit fly)Imported
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0109358. Dere\GG17130.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10776.
OrthoDBiEOG7BKCT2.
PhylomeDBiB3P1B6.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3P1B6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLPRLTWQT RFLTRLACNK MASKGLRNED NKFDTFRRIC DEIAGESSYL
60 70 80 90 100
KKAEKLQRFF EKGSSGKGFK GDTLLWVQFL IPEANQRVYN LQNKALIKLF
110 120 130 140 150
SRILNANQQQ MHLDLEQDGD VSETLRKHFA ASRKLKPQVQ SKLYLQEVEQ
160 170 180 190 200
LLLKLVERTK EDEQTELLHE LCSKATDLDL RTFIRLVKHD LRINARARHI
210 220 230 240 250
LDAFGSEAYP AYQSSRDLVA IVGQFAGKDN KKDAHSPIKK ANKTNSSAIQ
260 270 280 290 300
VMTPISPMLA SPCKSVEEAF KKSPTGLYSE IKYDGERVQI HKQGNEFKFF
310 320 330 340 350
SRNLKPVVDH KIRALKEYIP QAFPGGGEMI LDSEIILVDT DTGALLPFGS
360 370 380 390 400
LGAHKKQTFA NAAVCLFVFD CILYDGEDLT QLPFRKRREI LEQNIQPIKS
410 420 430 440 450
HVQLSESEFL KTTKELAVMT ARVLHANLEG VVLKSPTSTY QPGKRNWLKV
460 470 480 490 500
KKDYLFDGKM ADTADLVVLG AWYGSGKKGG TLSIFLMGCY DAFGRLWKTV
510 520 530 540 550
TKVHSGLDDA TNAEVHESLI KLTERADANA IPSWLLCSKS LVPDVLAKDP
560 570 580 590 600
LKMPVWEITG AEFTKSDAHT ASGISIRFPR ITRRRSDKSA KEANDLAHLE
610 620 630 640 650
DIFEASKTNV NVDLLLANCS KDEKAIDIKT SPQKEKKLNG NRSSSTKKLK
660 670 680 690 700
RRKTSTDDED EAPALSKHKE AKAIRSLSPS QKGLKDFFKP SKELKSVVKK
710 720 730 740 750
EPKQTENATE PTSSKGKLFE GLVAYFAMEK DSSKLMQQFS QHGGSCTTEP
760 770 780 790 800
RKANLVFYNT NEASDMEKLR RLYRRSCRHL NVSWLQNSLD TQSRQPYPLY

AVMMK
Length:805
Mass (Da):91,029
Last modified:September 2, 2008 - v1
Checksum:i7335881521A600D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV49375.1.
RefSeqiXP_001980417.1. XM_001980381.1.

Genome annotation databases

EnsemblMetazoaiFBtr0137184; FBpp0135676; FBgn0109358.
GeneIDi6553675.
KEGGider:Dere_GG17130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV49375.1.
RefSeqiXP_001980417.1. XM_001980381.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0137184; FBpp0135676; FBgn0109358.
GeneIDi6553675.
KEGGider:Dere_GG17130.

Organism-specific databases

FlyBaseiFBgn0109358. Dere\GG17130.

Phylogenomic databases

KOiK10776.
OrthoDBiEOG7BKCT2.
PhylomeDBiB3P1B6.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01Imported.

Entry informationi

Entry nameiB3P1B6_DROER
AccessioniPrimary (citable) accession number: B3P1B6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.