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Protein

Diacylglycerol kinase eta

Gene

GG14241

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GG14241
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0106502. Dere\GG14241.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19181918Diacylglycerol kinase etaPRO_0000375985Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHPROSITE-ProRule annotationAdd
BLAST
Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
BLAST
Domaini1855 – 191864SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3NYS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLKLDTLH VQRSPRGSRR SSPSSGRSSA CSSGSISPVP IIPIISISHD
60 70 80 90 100
GDESESESEI ETEPVRLFQR RMSTKCTNNL AAIIKEGFLL KHTWSFQRWR
110 120 130 140 150
RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT
160 170 180 190 200
RSLVLCAESR REMEDWLGGL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL
260 270 280 290 300
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC
310 320 330 340 350
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG
360 370 380 390 400
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR
410 420 430 440 450
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG
460 470 480 490 500
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST
510 520 530 540 550
EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH
560 570 580 590 600
HKEDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLITRSI
610 620 630 640 650
PVTPGSNAYL LNPNISIEKT EKDQINTKER RNSRSLRSSE KEALQCRANS
660 670 680 690 700
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG ESTPCTSPLP
710 720 730 740 750
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS
760 770 780 790 800
RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG
810 820 830 840 850
ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFERTYY MTREMDKDKE
860 870 880 890 900
KDKEKEKEKT AEIEEENDKC VEKLGSIPAE KLVHTCNLQV PGVVVTPNPQ
910 920 930 940 950
NVYSSASITI IDTDAQTTTE QSSSDDLGGE ASDVLSAISN EECSVASEIF
960 970 980 990 1000
DKQDAGQTVG DIIQNMDASN FTHIDSPETS DETEAMPGES LMDDISSVLG
1010 1020 1030 1040 1050
HDITYALQDN TLTDDTTTLC SEHAGPPKPP RKKSLSALSR TQAHPRRRNS
1060 1070 1080 1090 1100
SPPRTARLAR MDSDDNPQQF GFENIVFEID NRCDDQKMRE PPRYCSLAQF
1110 1120 1130 1140 1150
VEGNDIARQS FKQLMLEQHR GGDNDIESPE QQQAPTNKGA HLLATTSEDE
1160 1170 1180 1190 1200
LSTQTAIKIE IHDIDATVRS INSSMKPNTI LTTSTSPTKK SGHGQDISVV
1210 1220 1230 1240 1250
VRPPTPLRGD SIKPTVSLLP VSSGGAMAVS MTCSGMLGVR AMNASEIRRH
1260 1270 1280 1290 1300
SSHAPSLAVR EFDKDKDRRH SGFNPNQLTL DPEHARFLSS SPAASRRISC
1310 1320 1330 1340 1350
GSLFKKKNKK IATKRSYGLF SVRFFVVAEP DFRLATLALI RPLIPLPNEA
1360 1370 1380 1390 1400
LPNLQTLKGS KSSLFMGSTL FGFDHLASAE RDKEERGGKD KDKTPTEEAN
1410 1420 1430 1440 1450
RKLPIINPLV RLPNWPNLAN GGGFISKCLL ANADTLCAAV SPLMDPDETL
1460 1470 1480 1490 1500
LAGYHEKCVM NNYFGIGIDA KISLDFHNKR EEHPEKCRSR ARNYMWYGVL
1510 1520 1530 1540 1550
GSKQLLQKTC KNLEQRVQLE CDGQRIPLPE LQGIVILNIP SFMGGTNFWG
1560 1570 1580 1590 1600
SSTKKDDIFL PPSFDDRVLE VVAVFGSVQM AASRLINLQH HRIAQCQSVQ
1610 1620 1630 1640 1650
INILGDEEIP IQVDGEAWLQ PPGMIRILHK NRVQMLCRNR SLELSLKSWH
1660 1670 1680 1690 1700
EKQRQHSISI QRDASSTASE HANSTDEVIS ERECYVLLNF IEAVSSLVKW
1710 1720 1730 1740 1750
VKFLIISHPA LQHDLYEVAC RASEALESIH PQGKLLEGPS LRTKLVEVID
1760 1770 1780 1790 1800
SSRQLYDDAC TLLRDRGHSL ILREDLETKL SAALANMEME LKKCSVQKCI
1810 1820 1830 1840 1850
DGKLRAYFNV LAPNEESDGR RKSRPFWVRL RSGSTAGQQV FKPPLTNTRE
1860 1870 1880 1890 1900
AANNWSVNEV VTWLETMQLS EYVDSFLKND IRGKELLTLG RRDLKDLGVV
1910
KVGHVKRILQ AIKDLSEN
Length:1,918
Mass (Da):214,106
Last modified:May 25, 2009 - v2
Checksum:iF15B3649942C3926
GO

Sequence cautioni

The sequence EDV48187.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV48187.1. Sequence problems.
RefSeqiXP_001979229.1. XM_001979193.1.

Genome annotation databases

GeneIDi6553604.
KEGGider:Dere_GG14241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA. Translation: EDV48187.1. Sequence problems.
RefSeqiXP_001979229.1. XM_001979193.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6553604.
KEGGider:Dere_GG14241.

Organism-specific databases

FlyBaseiFBgn0106502. Dere\GG14241.

Phylogenomic databases

KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01Imported.

Entry informationi

Entry nameiDGKH_DROER
AccessioniPrimary (citable) accession number: B3NYS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 25, 2009
Last sequence update: May 25, 2009
Last modified: January 6, 2015
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.