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B3NYS4

- DGKH_DROER

UniProt

B3NYS4 - DGKH_DROER

Protein

Diacylglycerol kinase eta

Gene

GG14241

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    3. protein oligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
    Short name:
    DAG kinase etaBy similarity
    Gene namesi
    ORF Names:GG14241
    OrganismiDrosophila erecta (Fruit fly)
    Taxonomic identifieri7220 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008711: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0106502. Dere\GG14241.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19181918Diacylglycerol kinase etaPRO_0000375985Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 17594PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Domaini1855 – 191864SAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    KOiK00901.
    OrthoDBiEOG7DVD9B.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3NYS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHLKLDTLH VQRSPRGSRR SSPSSGRSSA CSSGSISPVP IIPIISISHD     50
    GDESESESEI ETEPVRLFQR RMSTKCTNNL AAIIKEGFLL KHTWSFQRWR 100
    RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT 150
    RSLVLCAESR REMEDWLGGL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA 200
    TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
    ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC 300
    LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
    NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
    HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
    WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST 500
    EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH 550
    HKEDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLITRSI 600
    PVTPGSNAYL LNPNISIEKT EKDQINTKER RNSRSLRSSE KEALQCRANS 650
    VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG ESTPCTSPLP 700
    IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS 750
    RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG 800
    ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFERTYY MTREMDKDKE 850
    KDKEKEKEKT AEIEEENDKC VEKLGSIPAE KLVHTCNLQV PGVVVTPNPQ 900
    NVYSSASITI IDTDAQTTTE QSSSDDLGGE ASDVLSAISN EECSVASEIF 950
    DKQDAGQTVG DIIQNMDASN FTHIDSPETS DETEAMPGES LMDDISSVLG 1000
    HDITYALQDN TLTDDTTTLC SEHAGPPKPP RKKSLSALSR TQAHPRRRNS 1050
    SPPRTARLAR MDSDDNPQQF GFENIVFEID NRCDDQKMRE PPRYCSLAQF 1100
    VEGNDIARQS FKQLMLEQHR GGDNDIESPE QQQAPTNKGA HLLATTSEDE 1150
    LSTQTAIKIE IHDIDATVRS INSSMKPNTI LTTSTSPTKK SGHGQDISVV 1200
    VRPPTPLRGD SIKPTVSLLP VSSGGAMAVS MTCSGMLGVR AMNASEIRRH 1250
    SSHAPSLAVR EFDKDKDRRH SGFNPNQLTL DPEHARFLSS SPAASRRISC 1300
    GSLFKKKNKK IATKRSYGLF SVRFFVVAEP DFRLATLALI RPLIPLPNEA 1350
    LPNLQTLKGS KSSLFMGSTL FGFDHLASAE RDKEERGGKD KDKTPTEEAN 1400
    RKLPIINPLV RLPNWPNLAN GGGFISKCLL ANADTLCAAV SPLMDPDETL 1450
    LAGYHEKCVM NNYFGIGIDA KISLDFHNKR EEHPEKCRSR ARNYMWYGVL 1500
    GSKQLLQKTC KNLEQRVQLE CDGQRIPLPE LQGIVILNIP SFMGGTNFWG 1550
    SSTKKDDIFL PPSFDDRVLE VVAVFGSVQM AASRLINLQH HRIAQCQSVQ 1600
    INILGDEEIP IQVDGEAWLQ PPGMIRILHK NRVQMLCRNR SLELSLKSWH 1650
    EKQRQHSISI QRDASSTASE HANSTDEVIS ERECYVLLNF IEAVSSLVKW 1700
    VKFLIISHPA LQHDLYEVAC RASEALESIH PQGKLLEGPS LRTKLVEVID 1750
    SSRQLYDDAC TLLRDRGHSL ILREDLETKL SAALANMEME LKKCSVQKCI 1800
    DGKLRAYFNV LAPNEESDGR RKSRPFWVRL RSGSTAGQQV FKPPLTNTRE 1850
    AANNWSVNEV VTWLETMQLS EYVDSFLKND IRGKELLTLG RRDLKDLGVV 1900
    KVGHVKRILQ AIKDLSEN 1918
    Length:1,918
    Mass (Da):214,106
    Last modified:May 26, 2009 - v2
    Checksum:iF15B3649942C3926
    GO

    Sequence cautioni

    The sequence EDV48187.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954181 Genomic DNA. Translation: EDV48187.1. Sequence problems.
    RefSeqiXP_001979229.1. XM_001979193.1.

    Genome annotation databases

    GeneIDi6553604.
    KEGGider:Dere_GG14241.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954181 Genomic DNA. Translation: EDV48187.1 . Sequence problems.
    RefSeqi XP_001979229.1. XM_001979193.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6553604.
    KEGGi der:Dere_GG14241.

    Organism-specific databases

    FlyBasei FBgn0106502. Dere\GG14241.

    Phylogenomic databases

    KOi K00901.
    OrthoDBi EOG7DVD9B.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14021-0224.01Imported.

    Entry informationi

    Entry nameiDGKH_DROER
    AccessioniPrimary (citable) accession number: B3NYS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3