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Protein

Diacylglycerol kinase eta

Gene

GG14241

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 245Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 319Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GG14241
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008711 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0106502 Dere\GG14241

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003759851 – 1918Diacylglycerol kinase etaAdd BLAST1918

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB3NYS4

Structurei

3D structure databases

SMRiB3NYS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 175PHPROSITE-ProRule annotationAdd BLAST94
Domaini350 – 486DAGKcPROSITE-ProRule annotationAdd BLAST137
Domaini1855 – 1918SAMPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 245Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 319Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK00901
OrthoDBiEOG091G07HR

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.30.29.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
PF00169 PH, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF111331 SSF111331, 2 hits
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

B3NYS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLKLDTLH VQRSPRGSRR SSPSSGRSSA CSSGSISPVP IIPIISISHD
60 70 80 90 100
GDESESESEI ETEPVRLFQR RMSTKCTNNL AAIIKEGFLL KHTWSFQRWR
110 120 130 140 150
RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT
160 170 180 190 200
RSLVLCAESR REMEDWLGGL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL
260 270 280 290 300
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC
310 320 330 340 350
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG
360 370 380 390 400
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR
410 420 430 440 450
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG
460 470 480 490 500
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST
510 520 530 540 550
EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH
560 570 580 590 600
HKEDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLITRSI
610 620 630 640 650
PVTPGSNAYL LNPNISIEKT EKDQINTKER RNSRSLRSSE KEALQCRANS
660 670 680 690 700
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG ESTPCTSPLP
710 720 730 740 750
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS
760 770 780 790 800
RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG
810 820 830 840 850
ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFERTYY MTREMDKDKE
860 870 880 890 900
KDKEKEKEKT AEIEEENDKC VEKLGSIPAE KLVHTCNLQV PGVVVTPNPQ
910 920 930 940 950
NVYSSASITI IDTDAQTTTE QSSSDDLGGE ASDVLSAISN EECSVASEIF
960 970 980 990 1000
DKQDAGQTVG DIIQNMDASN FTHIDSPETS DETEAMPGES LMDDISSVLG
1010 1020 1030 1040 1050
HDITYALQDN TLTDDTTTLC SEHAGPPKPP RKKSLSALSR TQAHPRRRNS
1060 1070 1080 1090 1100
SPPRTARLAR MDSDDNPQQF GFENIVFEID NRCDDQKMRE PPRYCSLAQF
1110 1120 1130 1140 1150
VEGNDIARQS FKQLMLEQHR GGDNDIESPE QQQAPTNKGA HLLATTSEDE
1160 1170 1180 1190 1200
LSTQTAIKIE IHDIDATVRS INSSMKPNTI LTTSTSPTKK SGHGQDISVV
1210 1220 1230 1240 1250
VRPPTPLRGD SIKPTVSLLP VSSGGAMAVS MTCSGMLGVR AMNASEIRRH
1260 1270 1280 1290 1300
SSHAPSLAVR EFDKDKDRRH SGFNPNQLTL DPEHARFLSS SPAASRRISC
1310 1320 1330 1340 1350
GSLFKKKNKK IATKRSYGLF SVRFFVVAEP DFRLATLALI RPLIPLPNEA
1360 1370 1380 1390 1400
LPNLQTLKGS KSSLFMGSTL FGFDHLASAE RDKEERGGKD KDKTPTEEAN
1410 1420 1430 1440 1450
RKLPIINPLV RLPNWPNLAN GGGFISKCLL ANADTLCAAV SPLMDPDETL
1460 1470 1480 1490 1500
LAGYHEKCVM NNYFGIGIDA KISLDFHNKR EEHPEKCRSR ARNYMWYGVL
1510 1520 1530 1540 1550
GSKQLLQKTC KNLEQRVQLE CDGQRIPLPE LQGIVILNIP SFMGGTNFWG
1560 1570 1580 1590 1600
SSTKKDDIFL PPSFDDRVLE VVAVFGSVQM AASRLINLQH HRIAQCQSVQ
1610 1620 1630 1640 1650
INILGDEEIP IQVDGEAWLQ PPGMIRILHK NRVQMLCRNR SLELSLKSWH
1660 1670 1680 1690 1700
EKQRQHSISI QRDASSTASE HANSTDEVIS ERECYVLLNF IEAVSSLVKW
1710 1720 1730 1740 1750
VKFLIISHPA LQHDLYEVAC RASEALESIH PQGKLLEGPS LRTKLVEVID
1760 1770 1780 1790 1800
SSRQLYDDAC TLLRDRGHSL ILREDLETKL SAALANMEME LKKCSVQKCI
1810 1820 1830 1840 1850
DGKLRAYFNV LAPNEESDGR RKSRPFWVRL RSGSTAGQQV FKPPLTNTRE
1860 1870 1880 1890 1900
AANNWSVNEV VTWLETMQLS EYVDSFLKND IRGKELLTLG RRDLKDLGVV
1910
KVGHVKRILQ AIKDLSEN
Length:1,918
Mass (Da):214,106
Last modified:May 26, 2009 - v2
Checksum:iF15B3649942C3926
GO

Sequence cautioni

The sequence EDV48187 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954181 Genomic DNA Translation: EDV48187.1 Sequence problems.
RefSeqiXP_001979229.2, XM_001979193.2

Genome annotation databases

GeneIDi6553604
KEGGider:Dere_GG14241

Similar proteinsi

Entry informationi

Entry nameiDGKH_DROER
AccessioniPrimary (citable) accession number: B3NYS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health