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B3NYS4

- DGKH_DROER

UniProt

B3NYS4 - DGKH_DROER

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Protein

Diacylglycerol kinase eta

Gene
GG14241
Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) By similarity.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Gene namesi
ORF Names:GG14241
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0106502. Dere\GG14241.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19181918Diacylglycerol kinase etaPRO_0000375985Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHAdd
BLAST
Domaini350 – 486137DAGKcAdd
BLAST
Domaini1855 – 191864SAMAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3NYS4-1 [UniParc]FASTAAdd to Basket

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MAHLKLDTLH VQRSPRGSRR SSPSSGRSSA CSSGSISPVP IIPIISISHD     50
GDESESESEI ETEPVRLFQR RMSTKCTNNL AAIIKEGFLL KHTWSFQRWR 100
RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT 150
RSLVLCAESR REMEDWLGGL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA 200
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC 300
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST 500
EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH 550
HKEDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLITRSI 600
PVTPGSNAYL LNPNISIEKT EKDQINTKER RNSRSLRSSE KEALQCRANS 650
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG ESTPCTSPLP 700
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS 750
RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG 800
ENTPTERKVD FLRVPIHTGE PIVDPLCDYR PHEVFERTYY MTREMDKDKE 850
KDKEKEKEKT AEIEEENDKC VEKLGSIPAE KLVHTCNLQV PGVVVTPNPQ 900
NVYSSASITI IDTDAQTTTE QSSSDDLGGE ASDVLSAISN EECSVASEIF 950
DKQDAGQTVG DIIQNMDASN FTHIDSPETS DETEAMPGES LMDDISSVLG 1000
HDITYALQDN TLTDDTTTLC SEHAGPPKPP RKKSLSALSR TQAHPRRRNS 1050
SPPRTARLAR MDSDDNPQQF GFENIVFEID NRCDDQKMRE PPRYCSLAQF 1100
VEGNDIARQS FKQLMLEQHR GGDNDIESPE QQQAPTNKGA HLLATTSEDE 1150
LSTQTAIKIE IHDIDATVRS INSSMKPNTI LTTSTSPTKK SGHGQDISVV 1200
VRPPTPLRGD SIKPTVSLLP VSSGGAMAVS MTCSGMLGVR AMNASEIRRH 1250
SSHAPSLAVR EFDKDKDRRH SGFNPNQLTL DPEHARFLSS SPAASRRISC 1300
GSLFKKKNKK IATKRSYGLF SVRFFVVAEP DFRLATLALI RPLIPLPNEA 1350
LPNLQTLKGS KSSLFMGSTL FGFDHLASAE RDKEERGGKD KDKTPTEEAN 1400
RKLPIINPLV RLPNWPNLAN GGGFISKCLL ANADTLCAAV SPLMDPDETL 1450
LAGYHEKCVM NNYFGIGIDA KISLDFHNKR EEHPEKCRSR ARNYMWYGVL 1500
GSKQLLQKTC KNLEQRVQLE CDGQRIPLPE LQGIVILNIP SFMGGTNFWG 1550
SSTKKDDIFL PPSFDDRVLE VVAVFGSVQM AASRLINLQH HRIAQCQSVQ 1600
INILGDEEIP IQVDGEAWLQ PPGMIRILHK NRVQMLCRNR SLELSLKSWH 1650
EKQRQHSISI QRDASSTASE HANSTDEVIS ERECYVLLNF IEAVSSLVKW 1700
VKFLIISHPA LQHDLYEVAC RASEALESIH PQGKLLEGPS LRTKLVEVID 1750
SSRQLYDDAC TLLRDRGHSL ILREDLETKL SAALANMEME LKKCSVQKCI 1800
DGKLRAYFNV LAPNEESDGR RKSRPFWVRL RSGSTAGQQV FKPPLTNTRE 1850
AANNWSVNEV VTWLETMQLS EYVDSFLKND IRGKELLTLG RRDLKDLGVV 1900
KVGHVKRILQ AIKDLSEN 1918
Length:1,918
Mass (Da):214,106
Last modified:May 26, 2009 - v2
Checksum:iF15B3649942C3926
GO

Sequence cautioni

The sequence EDV48187.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954181 Genomic DNA. Translation: EDV48187.1. Sequence problems.
RefSeqiXP_001979229.1. XM_001979193.1.

Genome annotation databases

GeneIDi6553604.
KEGGider:Dere_GG14241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954181 Genomic DNA. Translation: EDV48187.1 . Sequence problems.
RefSeqi XP_001979229.1. XM_001979193.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6553604.
KEGGi der:Dere_GG14241.

Organism-specific databases

FlyBasei FBgn0106502. Dere\GG14241.

Phylogenomic databases

KOi K00901.
OrthoDBi EOG7DVD9B.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiDGKH_DROER
AccessioniPrimary (citable) accession number: B3NYS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi