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B3NY03

- SWS_DROER

UniProt

B3NY03 - SWS_DROER

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Protein
Neuropathy target esterase sws
Gene
sws, GG17592
Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei987 – 9871 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 301128cNMP 1
Add
BLAST
Nucleotide bindingi484 – 611128cNMP 2
Add
BLAST
Nucleotide bindingi600 – 727128cNMP 3
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BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GG17592
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0109816. Dere\GG17592.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Topological domaini56 – 14651410Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14651465Neuropathy target esterase sws
PRO_0000389221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei446 – 4461Phosphoserine By similarityBy similarity
Modified residuei455 – 4551Phosphoserine By similarityBy similarity
Modified residuei1201 – 12011Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB3NY03.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini954 – 1120167Patatin
Add
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB3NY03.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3NY03-1 [UniParc]FASTAAdd to Basket

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MDVLEMLRAS ASGSYNTIFS EAWCQYVSKQ ITATMYMYCA LGMMGVLFLA     50
WFMYFKRMAR LRLRDEIARS ISAVTNSSGD LRGLRFRKRD KMLFYGRRML 100
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY 150
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY 200
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID 250
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQTPN 350
GPPMGISHPL NLMQSTASGT GSGSGSGVSV TVTRPPPSPS RHSREEHTLS 400
DPNPNPDGSV HGTSNLFTEV HGDAPNADLF HQQQQSVGNL STRRSSITQM 450
TPDGSHSCPP APGVTTSIDM RLVQSSAVES LRKELGLSEE DAHIIEPFVE 500
LRELEPNVTL ITEGNADDVC VWFVMTGTLA VYQSNQDATR AKQDKSDMLI 550
HFVHPGEIVG GLAMLTGEAS AYTIRSRSNS RIAFIRRAAI YQIMRQRPRI 600
VLDLGNGVVR RLSPLVRQCD YALDWIFLES GRAVYRQDES SDSTYIVLSG 650
RMRSVITHPG GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK 700
LPEGLFNAIK LRYPIVVTKL ISFLSHRFLG SMQTRSGSGA PGAPVEANPV 750
THKYSTVALV PITDEVPLTP FTYELYHSLC AIGPVLRLTS DVVRKQLGPN 800
IFEAANEYRL TSWLAQQEDR NIITLYQCDS SLSAWTQRCM RQADVILIVG 850
LGDRSHLVGK FEREIDRLAM RTQKELVLLY PEATNAKPAN TLSWLNARPW 900
VTKHHHVLCV KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN 950
SIGLVLGGGG ARGAAHIGML KAIQEAGIPV DMVGGVSIGA LMGALWCSER 1000
NITTVTQKAR EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHDTFGDV 1050
SIEDLWIPYF TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK 1100
DGHLLLDGGY VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT 1150
NNVPADVMHN LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT 1200
SPVKVPDLPD IQSRLAYVSC VRQLEEVKNS DYCEYIRPPI DKYKTLAFGS 1250
FDEIRDVGYV FGKNYFENMA KAGRLGRFNQ WFNKEPPKRV NHASLNEYTF 1300
IDLAQIVCRL PETYAVNTAD LFSEDEDCDG YISEPTTLNT DRRRIQVPRA 1350
GNSLSFSETE MDSDVELDLK LERKTDKSTQ SSPPTSSRTS MRGKEEARHM 1400
DNWHWGAKHK NETGSGATEG IHTSTEQEQE HQQQQQQDQG VRAEQLVYKD 1450
EDKENRSSAN NETKN 1465
Length:1,465
Mass (Da):164,841
Last modified:September 2, 2008 - v1
Checksum:i8769CA5C323E3F70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954180 Genomic DNA. Translation: EDV47524.1.
RefSeqiXP_001978597.1. XM_001978561.1.

Genome annotation databases

EnsemblMetazoaiFBtr0137646; FBpp0136138; FBgn0109816.
GeneIDi6551558.
KEGGider:Dere_GG17592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954180 Genomic DNA. Translation: EDV47524.1 .
RefSeqi XP_001978597.1. XM_001978561.1.

3D structure databases

ProteinModelPortali B3NY03.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0137646 ; FBpp0136138 ; FBgn0109816 .
GeneIDi 6551558.
KEGGi der:Dere_GG17592.

Organism-specific databases

FlyBasei FBgn0109816. Dere\GG17592.

Phylogenomic databases

KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B3NY03.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiSWS_DROER
AccessioniPrimary (citable) accession number: B3NY03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi