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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei987NucleophilePROSITE-ProRule annotation1
Active sitei1107Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi174 – 301cNMP 1Sequence analysisAdd BLAST128
Nucleotide bindingi484 – 611cNMP 2Sequence analysisAdd BLAST128
Nucleotide bindingi600 – 727cNMP 3Sequence analysisAdd BLAST128

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GG17592
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008711 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0109816. Dere\GG17592.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Sws tethers Pka-C3 to the membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34LumenalSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 1465CytoplasmicSequence analysisAdd BLAST1410

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003892211 – 1465Neuropathy target esterase swsAdd BLAST1465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei446PhosphoserineBy similarity1
Modified residuei455PhosphoserineBy similarity1
Modified residuei1201PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Structurei

3D structure databases

ProteinModelPortaliB3NY03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini954 – 1120PNPLAPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi958 – 963GXGXXGPROSITE-ProRule annotation6
Motifi985 – 989GXSXGPROSITE-ProRule annotation5
Motifi1107 – 1109DGA/GPROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the NTE family.Sequence analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 PNPLA (patatin-like phospholipase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OMAiIRMSAFV.
OrthoDBiEOG091G00XM.
PhylomeDBiB3NY03.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3NY03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLEMLRAS ASGSYNTIFS EAWCQYVSKQ ITATMYMYCA LGMMGVLFLA
60 70 80 90 100
WFMYFKRMAR LRLRDEIARS ISAVTNSSGD LRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQTPN
360 370 380 390 400
GPPMGISHPL NLMQSTASGT GSGSGSGVSV TVTRPPPSPS RHSREEHTLS
410 420 430 440 450
DPNPNPDGSV HGTSNLFTEV HGDAPNADLF HQQQQSVGNL STRRSSITQM
460 470 480 490 500
TPDGSHSCPP APGVTTSIDM RLVQSSAVES LRKELGLSEE DAHIIEPFVE
510 520 530 540 550
LRELEPNVTL ITEGNADDVC VWFVMTGTLA VYQSNQDATR AKQDKSDMLI
560 570 580 590 600
HFVHPGEIVG GLAMLTGEAS AYTIRSRSNS RIAFIRRAAI YQIMRQRPRI
610 620 630 640 650
VLDLGNGVVR RLSPLVRQCD YALDWIFLES GRAVYRQDES SDSTYIVLSG
660 670 680 690 700
RMRSVITHPG GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK
710 720 730 740 750
LPEGLFNAIK LRYPIVVTKL ISFLSHRFLG SMQTRSGSGA PGAPVEANPV
760 770 780 790 800
THKYSTVALV PITDEVPLTP FTYELYHSLC AIGPVLRLTS DVVRKQLGPN
810 820 830 840 850
IFEAANEYRL TSWLAQQEDR NIITLYQCDS SLSAWTQRCM RQADVILIVG
860 870 880 890 900
LGDRSHLVGK FEREIDRLAM RTQKELVLLY PEATNAKPAN TLSWLNARPW
910 920 930 940 950
VTKHHHVLCV KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN
960 970 980 990 1000
SIGLVLGGGG ARGAAHIGML KAIQEAGIPV DMVGGVSIGA LMGALWCSER
1010 1020 1030 1040 1050
NITTVTQKAR EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHDTFGDV
1060 1070 1080 1090 1100
SIEDLWIPYF TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK
1110 1120 1130 1140 1150
DGHLLLDGGY VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT
1160 1170 1180 1190 1200
NNVPADVMHN LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT
1210 1220 1230 1240 1250
SPVKVPDLPD IQSRLAYVSC VRQLEEVKNS DYCEYIRPPI DKYKTLAFGS
1260 1270 1280 1290 1300
FDEIRDVGYV FGKNYFENMA KAGRLGRFNQ WFNKEPPKRV NHASLNEYTF
1310 1320 1330 1340 1350
IDLAQIVCRL PETYAVNTAD LFSEDEDCDG YISEPTTLNT DRRRIQVPRA
1360 1370 1380 1390 1400
GNSLSFSETE MDSDVELDLK LERKTDKSTQ SSPPTSSRTS MRGKEEARHM
1410 1420 1430 1440 1450
DNWHWGAKHK NETGSGATEG IHTSTEQEQE HQQQQQQDQG VRAEQLVYKD
1460
EDKENRSSAN NETKN
Length:1,465
Mass (Da):164,841
Last modified:September 2, 2008 - v1
Checksum:i8769CA5C323E3F70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954180 Genomic DNA. Translation: EDV47524.1.
RefSeqiXP_001978597.2. XM_001978561.2.

Genome annotation databases

EnsemblMetazoaiFBtr0137646; FBpp0136138; FBgn0109816.
GeneIDi6551558.
KEGGider:Dere_GG17592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954180 Genomic DNA. Translation: EDV47524.1.
RefSeqiXP_001978597.2. XM_001978561.2.

3D structure databases

ProteinModelPortaliB3NY03.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0137646; FBpp0136138; FBgn0109816.
GeneIDi6551558.
KEGGider:Dere_GG17592.

Organism-specific databases

FlyBaseiFBgn0109816. Dere\GG17592.

Phylogenomic databases

KOiK14676.
OMAiIRMSAFV.
OrthoDBiEOG091G00XM.
PhylomeDBiB3NY03.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWS_DROER
AccessioniPrimary (citable) accession number: B3NY03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.