Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B3NY03

- SWS_DROER

UniProt

B3NY03 - SWS_DROER

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei987 – 9871By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi174 – 301128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi484 – 611128cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi600 – 727128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GG17592
    OrganismiDrosophila erecta (Fruit fly)
    Taxonomic identifieri7220 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008711: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0109816. Dere\GG17592.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14651465Neuropathy target esterase swsPRO_0000389221Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei446 – 4461PhosphoserineBy similarity
    Modified residuei455 – 4551PhosphoserineBy similarity
    Modified residuei1201 – 12011PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB3NY03.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14651410CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini954 – 1120167PatatinSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK14676.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB3NY03.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3NY03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLEMLRAS ASGSYNTIFS EAWCQYVSKQ ITATMYMYCA LGMMGVLFLA     50
    WFMYFKRMAR LRLRDEIARS ISAVTNSSGD LRGLRFRKRD KMLFYGRRML 100
    RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY 150
    LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY 200
    LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID 250
    VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
    RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQTPN 350
    GPPMGISHPL NLMQSTASGT GSGSGSGVSV TVTRPPPSPS RHSREEHTLS 400
    DPNPNPDGSV HGTSNLFTEV HGDAPNADLF HQQQQSVGNL STRRSSITQM 450
    TPDGSHSCPP APGVTTSIDM RLVQSSAVES LRKELGLSEE DAHIIEPFVE 500
    LRELEPNVTL ITEGNADDVC VWFVMTGTLA VYQSNQDATR AKQDKSDMLI 550
    HFVHPGEIVG GLAMLTGEAS AYTIRSRSNS RIAFIRRAAI YQIMRQRPRI 600
    VLDLGNGVVR RLSPLVRQCD YALDWIFLES GRAVYRQDES SDSTYIVLSG 650
    RMRSVITHPG GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK 700
    LPEGLFNAIK LRYPIVVTKL ISFLSHRFLG SMQTRSGSGA PGAPVEANPV 750
    THKYSTVALV PITDEVPLTP FTYELYHSLC AIGPVLRLTS DVVRKQLGPN 800
    IFEAANEYRL TSWLAQQEDR NIITLYQCDS SLSAWTQRCM RQADVILIVG 850
    LGDRSHLVGK FEREIDRLAM RTQKELVLLY PEATNAKPAN TLSWLNARPW 900
    VTKHHHVLCV KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN 950
    SIGLVLGGGG ARGAAHIGML KAIQEAGIPV DMVGGVSIGA LMGALWCSER 1000
    NITTVTQKAR EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHDTFGDV 1050
    SIEDLWIPYF TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK 1100
    DGHLLLDGGY VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT 1150
    NNVPADVMHN LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT 1200
    SPVKVPDLPD IQSRLAYVSC VRQLEEVKNS DYCEYIRPPI DKYKTLAFGS 1250
    FDEIRDVGYV FGKNYFENMA KAGRLGRFNQ WFNKEPPKRV NHASLNEYTF 1300
    IDLAQIVCRL PETYAVNTAD LFSEDEDCDG YISEPTTLNT DRRRIQVPRA 1350
    GNSLSFSETE MDSDVELDLK LERKTDKSTQ SSPPTSSRTS MRGKEEARHM 1400
    DNWHWGAKHK NETGSGATEG IHTSTEQEQE HQQQQQQDQG VRAEQLVYKD 1450
    EDKENRSSAN NETKN 1465
    Length:1,465
    Mass (Da):164,841
    Last modified:September 2, 2008 - v1
    Checksum:i8769CA5C323E3F70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954180 Genomic DNA. Translation: EDV47524.1.
    RefSeqiXP_001978597.1. XM_001978561.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0137646; FBpp0136138; FBgn0109816.
    GeneIDi6551558.
    KEGGider:Dere_GG17592.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954180 Genomic DNA. Translation: EDV47524.1 .
    RefSeqi XP_001978597.1. XM_001978561.1.

    3D structure databases

    ProteinModelPortali B3NY03.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0137646 ; FBpp0136138 ; FBgn0109816 .
    GeneIDi 6551558.
    KEGGi der:Dere_GG17592.

    Organism-specific databases

    FlyBasei FBgn0109816. Dere\GG17592.

    Phylogenomic databases

    KOi K14676.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B3NY03.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14021-0224.01Imported.

    Entry informationi

    Entry nameiSWS_DROER
    AccessioniPrimary (citable) accession number: B3NY03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3