B3NQ53 (KAD2_DROER) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 2, mitochondrial
Short name=AK 2
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 2

Gene names

Name:	Adk2
ORF Names:	GG22922

Organism

Drosophila erecta (Fruit fly) [Complete proteome]

Taxonomic identifier

7220 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Adenylate kinase 2, mitochondrial		PRO_0000365704
Regions
	Nucleotide binding	25 – 33	9	ATP By similarity
	Nucleotide binding	48 – 77	30	AMP By similarity
Sites
	Binding site	49	1	AMP By similarity
Amino acid modifications
	Modified residue	48	1	Phosphoserine By similarity
	Disulfide bond	45 ↔ 95		By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3NQ53 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 5AB4622D86FCB098	FASTA	240	26,575
	10 20 30 40 50 60 MAPNAAVPVE RYEPQTLGIN AILLGPPGSG KGTQAPLLKE KFCVCHLSTG DMLRAEISSG 70 80 90 100 110 120 SKLGAELKKV MDAGKLVSDE LVVDMIDSNL DKPECKNGFL LDGFPRTVVQ AEKLDTLLDK 130 140 150 160 170 180 RKTNLDAVIE FAIDDNLLVR RITGRLIHQA SGRSYHEEFA PPKKSMTDDV TGEPLIRRSD 190 200 210 220 230 240 DNAEALKKRL EAYHKQTRPL VDYYGLRGLH FKVDAAKKSS DVFSAIDNIF QRKRSAQIQL

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 14021-0224.01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH954179 Genomic DNA. Translation: EDV56926.1.
RefSeq	XP_001976526.1. XM_001976490.1.
3D structure databases
ProteinModelPortal	B3NQ53.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0142976; FBpp0141468; FBgn0115079.
GeneID	6548394.
KEGG	der:Dere_GG22922.
Organism-specific databases
FlyBase	FBgn0115079. Dere\GG22922.
Phylogenomic databases
GeneTree	EMGT00050000010442.
OrthoDB	EOG43BK4X.
PhylomeDB	B3NQ53.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD2_DROER

Accession

Primary (citable) accession number: B3NQ53

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project