Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B3NPV7

- CALYP_DROER

UniProt

B3NPV7 - CALYP_DROER

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311NucleophileBy similarity
Active sitei213 – 2131Proton donorBy similarity
Sitei228 – 2281Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:GG22294
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0114466. Dere\GG22294.

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs).By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: UniProtKB
  2. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395827Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

KOiK08588.
OrthoDBiEOG7GN2M2.
PhylomeDBiB3NPV7.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B3NPV7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAAGGGSGS QAAGAAGGNS SLSHNALLAT ASGATTMPMA QLADGWLELE
60 70 80 90 100
SDPGLFTLLL KDFGCHDVQV EEVYDLQKPI ESPYGFIFLF RWIEERRARR
110 120 130 140 150
KIVETTAEIF VKDEEAISSI FFAQQVVPNS CATHALLSVL LNCNENNLQL
160 170 180 190 200
GDTLSRLKVH TKGMSPENKG LAIGNTPELA CAHNSHAMPQ ARRRLERTGA
210 220 230 240 250
GVSSCRFTGE AFHFVSFVPI NGQLFELDGL KPYPMNHGGW EDSEDWTDKF
260 270 280 290 300
RRVMAERLGI ATGEQDIRFN LMAVVPDRRI AITHKLKMLR TNQAIVSGTL
310 320 330 340 350
QKLLKADEQG ESGNGDSQRP DTPTTLLEPS AFTARDLQSL LKNLDTEIAI
360 370 380 390 400
NEQHLADEND RRHMFKVDAS RRTHNYDKFI CTFLSMLAHQ GVLGELVSQH
410 420 430 440 450
LLPSKKVSGQ GAANRISKQS TTASAGGSTA GASAATPKTQ QQQAAAAKNG
460 470
KSPSKTPGRR RKGRNKCRKR K
Length:471
Mass (Da):51,392
Last modified:September 2, 2008 - v1
Checksum:i807BCDEBE441BFAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954179 Genomic DNA. Translation: EDV55804.1.
RefSeqiXP_001975404.1. XM_001975368.1.

Genome annotation databases

EnsemblMetazoaiFBtr0142348; FBpp0140840; FBgn0114466.
GeneIDi6548522.
KEGGider:Dere_GG22294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954179 Genomic DNA. Translation: EDV55804.1 .
RefSeqi XP_001975404.1. XM_001975368.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C12.A09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0142348 ; FBpp0140840 ; FBgn0114466 .
GeneIDi 6548522.
KEGGi der:Dere_GG22294.

Organism-specific databases

FlyBasei FBgn0114466. Dere\GG22294.

Phylogenomic databases

KOi K08588.
OrthoDBi EOG7GN2M2.
PhylomeDBi B3NPV7.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiCALYP_DROER
AccessioniPrimary (citable) accession number: B3NPV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3