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B3NPV7 (CALYP_DROER) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase calypso

EC=3.4.19.12
Alternative name(s):
BAP1 homolog
Gene names
Name:calypso
ORF Names:GG22294
OrganismDrosophila erecta (Fruit fly) [Complete proteome]
Taxonomic identifier7220 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex, at least composed of calypso and Asx By similarity.

Subcellular location

Nucleus By similarity. Note: Localizes to PcG response elements (PREs) By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Ubiquitin carboxyl-terminal hydrolase calypso
PRO_0000395827

Sites

Active site1311Nucleophile By similarity
Active site2131Proton donor By similarity
Site2281Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B3NPV7 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 807BCDEBE441BFAF

FASTA47151,392
        10         20         30         40         50         60 
MNAAGGGSGS QAAGAAGGNS SLSHNALLAT ASGATTMPMA QLADGWLELE SDPGLFTLLL 

        70         80         90        100        110        120 
KDFGCHDVQV EEVYDLQKPI ESPYGFIFLF RWIEERRARR KIVETTAEIF VKDEEAISSI 

       130        140        150        160        170        180 
FFAQQVVPNS CATHALLSVL LNCNENNLQL GDTLSRLKVH TKGMSPENKG LAIGNTPELA 

       190        200        210        220        230        240 
CAHNSHAMPQ ARRRLERTGA GVSSCRFTGE AFHFVSFVPI NGQLFELDGL KPYPMNHGGW 

       250        260        270        280        290        300 
EDSEDWTDKF RRVMAERLGI ATGEQDIRFN LMAVVPDRRI AITHKLKMLR TNQAIVSGTL 

       310        320        330        340        350        360 
QKLLKADEQG ESGNGDSQRP DTPTTLLEPS AFTARDLQSL LKNLDTEIAI NEQHLADEND 

       370        380        390        400        410        420 
RRHMFKVDAS RRTHNYDKFI CTFLSMLAHQ GVLGELVSQH LLPSKKVSGQ GAANRISKQS 

       430        440        450        460        470 
TTASAGGSTA GASAATPKTQ QQQAAAAKNG KSPSKTPGRR RKGRNKCRKR K 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14021-0224.01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH954179 Genomic DNA. Translation: EDV55804.1.
RefSeqXP_001975404.1. XM_001975368.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC12.A09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0142348; FBpp0140840; FBgn0114466.
GeneID6548522.
KEGGder:Dere_GG22294.

Organism-specific databases

FlyBaseFBgn0114466. Dere\GG22294.

Phylogenomic databases

KOK08588.
OrthoDBEOG7GN2M2.
PhylomeDBB3NPV7.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Entry information

Entry nameCALYP_DROER
AccessionPrimary (citable) accession number: B3NPV7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase