Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B3NC86

- UBP36_DROER

UniProt

B3NC86 - UBP36_DROER

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei182 – 1821NucleophilePROSITE-ProRule annotation
    Active sitei440 – 4401Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GG15285
    OrganismiDrosophila erecta (Fruit fly)
    Taxonomic identifieri7220 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008711: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0107537. Dere\GG15285.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10851085Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei514 – 5141PhosphoserineBy similarity
    Modified residuei516 – 5161PhosphoserineBy similarity
    Modified residuei660 – 6601PhosphothreonineBy similarity
    Modified residuei664 – 6641PhosphothreonineBy similarity
    Modified residuei674 – 6741PhosphoserineBy similarity
    Modified residuei676 – 6761PhosphoserineBy similarity
    Modified residuei749 – 7491PhosphoserineBy similarity
    Modified residuei781 – 7811PhosphoserineBy similarity
    Modified residuei784 – 7841PhosphothreonineBy similarity
    Modified residuei787 – 7871PhosphoserineBy similarity
    Modified residuei825 – 8251PhosphothreonineBy similarity
    Modified residuei843 – 8431PhosphoserineBy similarity
    Modified residuei846 – 8461PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 481309USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    KOiK11855.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB3NC86.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3NC86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSADQAKSGE ESNGSLQNHI     50
    VANAKRILMA KIEYEEVPNY HESVLESLKS KYIVIKPGNP GAINGFGGKN 100
    NTGKVVGANG HDNNGARKQA EHPNNQSHHN NHNNHPHPTS NPNELPKPKR 150
    VLYPRENIRI GWKQSERKWQ VGTGMINVGN TCYLNSTLQA LLHIPALANW 200
    LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR PFLIYSKLKQ 250
    ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ 300
    IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADTLED AFEGHFSRER 350
    LEDMGYKCEG CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISF 400
    KPRIDLSKYA ARSPAAQAQP LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG 450
    SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL DLSQTASPAA NRPNGMRLTN 500
    GHSTTPVPAT TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK TAIQFKQHHQ 550
    QSQQNGFQLG TGKFQDTAKP PLVGAHAKGE ANPAPTANGN KSSSTSSNNS 600
    SSSNHKSINQ QQYLPISSED EDSEDERTSR PSTVQLPSMP KMTDDHTEKP 650
    KSPVKIQAKT PIKTPLKSLV PYESASEEEE APLPNPRKRR SGEDSSESDQ 700
    ESGQTNGHSK TNGSLTNGSA SSSVHVNNSK LKTDAIDEIF KSLKKSADSD 750
    DDDDEEESSI QLTNGWHPQK QSQSQSKAPP SPKTPPSPAV IKSKTGIWKV 800
    TRNDEVDDID DDDDEEEEAT VKIQTPSKTH RNPFSSSKPS TDSPATPGAK 850
    RQKLLNGSPV KSHQQPRVGN GYQSEATSNG STINELLKQS HRGYGSSVLS 900
    WNGKPAELEK ETFELVCAKR IAGHGSVDGS DIVESSVAVN ASSGSDSNDV 950
    VVIAVALLVD AREQRQRDLD DDEENEMDRG RQRKVKSGSA KGNNASNSTP 1000
    GYNPFQEYEG QKRWNKNGGG GGGFPRFYNQ NFRQNFQQRN KFKFNRFGGP 1050
    GGAKFQQQRA LQRHLAAGGG FSRRQPSAQQ QQQQS 1085
    Length:1,085
    Mass (Da):118,856
    Last modified:September 2, 2008 - v1
    Checksum:i5C90048688306DA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954178 Genomic DNA. Translation: EDV51044.1.
    RefSeqiXP_001972018.1. XM_001971982.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0135339; FBpp0133831; FBgn0107537.
    GeneIDi6544695.
    KEGGider:Dere_GG15285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH954178 Genomic DNA. Translation: EDV51044.1 .
    RefSeqi XP_001972018.1. XM_001971982.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0135339 ; FBpp0133831 ; FBgn0107537 .
    GeneIDi 6544695.
    KEGGi der:Dere_GG15285.

    Organism-specific databases

    FlyBasei FBgn0107537. Dere\GG15285.

    Phylogenomic databases

    KOi K11855.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B3NC86.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14021-0224.01.

    Entry informationi

    Entry nameiUBP36_DROER
    AccessioniPrimary (citable) accession number: B3NC86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3