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B3NC86

- UBP36_DROER

UniProt

B3NC86 - UBP36_DROER

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene
Usp36, scny, GG15285
Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Nucleophile By similarity
Active sitei440 – 4401Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GG15285
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0107537. Dere\GG15285.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10851085Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei514 – 5141Phosphoserine By similarity
Modified residuei516 – 5161Phosphoserine By similarity
Modified residuei660 – 6601Phosphothreonine By similarity
Modified residuei664 – 6641Phosphothreonine By similarity
Modified residuei674 – 6741Phosphoserine By similarity
Modified residuei676 – 6761Phosphoserine By similarity
Modified residuei749 – 7491Phosphoserine By similarity
Modified residuei781 – 7811Phosphoserine By similarity
Modified residuei784 – 7841Phosphothreonine By similarity
Modified residuei787 – 7871Phosphoserine By similarity
Modified residuei825 – 8251Phosphothreonine By similarity
Modified residuei843 – 8431Phosphoserine By similarity
Modified residuei846 – 8461Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 481309USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB3NC86.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3NC86-1 [UniParc]FASTAAdd to Basket

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MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSADQAKSGE ESNGSLQNHI     50
VANAKRILMA KIEYEEVPNY HESVLESLKS KYIVIKPGNP GAINGFGGKN 100
NTGKVVGANG HDNNGARKQA EHPNNQSHHN NHNNHPHPTS NPNELPKPKR 150
VLYPRENIRI GWKQSERKWQ VGTGMINVGN TCYLNSTLQA LLHIPALANW 200
LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR PFLIYSKLKQ 250
ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ 300
IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADTLED AFEGHFSRER 350
LEDMGYKCEG CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISF 400
KPRIDLSKYA ARSPAAQAQP LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG 450
SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL DLSQTASPAA NRPNGMRLTN 500
GHSTTPVPAT TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK TAIQFKQHHQ 550
QSQQNGFQLG TGKFQDTAKP PLVGAHAKGE ANPAPTANGN KSSSTSSNNS 600
SSSNHKSINQ QQYLPISSED EDSEDERTSR PSTVQLPSMP KMTDDHTEKP 650
KSPVKIQAKT PIKTPLKSLV PYESASEEEE APLPNPRKRR SGEDSSESDQ 700
ESGQTNGHSK TNGSLTNGSA SSSVHVNNSK LKTDAIDEIF KSLKKSADSD 750
DDDDEEESSI QLTNGWHPQK QSQSQSKAPP SPKTPPSPAV IKSKTGIWKV 800
TRNDEVDDID DDDDEEEEAT VKIQTPSKTH RNPFSSSKPS TDSPATPGAK 850
RQKLLNGSPV KSHQQPRVGN GYQSEATSNG STINELLKQS HRGYGSSVLS 900
WNGKPAELEK ETFELVCAKR IAGHGSVDGS DIVESSVAVN ASSGSDSNDV 950
VVIAVALLVD AREQRQRDLD DDEENEMDRG RQRKVKSGSA KGNNASNSTP 1000
GYNPFQEYEG QKRWNKNGGG GGGFPRFYNQ NFRQNFQQRN KFKFNRFGGP 1050
GGAKFQQQRA LQRHLAAGGG FSRRQPSAQQ QQQQS 1085
Length:1,085
Mass (Da):118,856
Last modified:September 2, 2008 - v1
Checksum:i5C90048688306DA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954178 Genomic DNA. Translation: EDV51044.1.
RefSeqiXP_001972018.1. XM_001971982.1.

Genome annotation databases

EnsemblMetazoaiFBtr0135339; FBpp0133831; FBgn0107537.
GeneIDi6544695.
KEGGider:Dere_GG15285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH954178 Genomic DNA. Translation: EDV51044.1 .
RefSeqi XP_001972018.1. XM_001971982.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0135339 ; FBpp0133831 ; FBgn0107537 .
GeneIDi 6544695.
KEGGi der:Dere_GG15285.

Organism-specific databases

FlyBasei FBgn0107537. Dere\GG15285.

Phylogenomic databases

KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B3NC86.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiUBP36_DROER
AccessioniPrimary (citable) accession number: B3NC86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi