Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei182NucleophilePROSITE-ProRule annotation1
Active sitei440Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GG15285
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008711 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0107537. Dere\GG15285.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784961 – 1085Ubiquitin carboxyl-terminal hydrolase 36Add BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514PhosphoserineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei660PhosphothreonineBy similarity1
Modified residuei664PhosphothreonineBy similarity1
Modified residuei674PhosphoserineBy similarity1
Modified residuei676PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei781PhosphoserineBy similarity1
Modified residuei784PhosphothreonineBy similarity1
Modified residuei787PhosphoserineBy similarity1
Modified residuei825PhosphothreonineBy similarity1
Modified residuei843PhosphoserineBy similarity1
Modified residuei846PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 481USPAdd BLAST309

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

KOiK11855.
OMAiSKYIVIK.
OrthoDBiEOG091G06D5.
PhylomeDBiB3NC86.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3NC86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSADQAKSGE ESNGSLQNHI
60 70 80 90 100
VANAKRILMA KIEYEEVPNY HESVLESLKS KYIVIKPGNP GAINGFGGKN
110 120 130 140 150
NTGKVVGANG HDNNGARKQA EHPNNQSHHN NHNNHPHPTS NPNELPKPKR
160 170 180 190 200
VLYPRENIRI GWKQSERKWQ VGTGMINVGN TCYLNSTLQA LLHIPALANW
210 220 230 240 250
LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR PFLIYSKLKQ
260 270 280 290 300
ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ
310 320 330 340 350
IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADTLED AFEGHFSRER
360 370 380 390 400
LEDMGYKCEG CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISF
410 420 430 440 450
KPRIDLSKYA ARSPAAQAQP LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG
460 470 480 490 500
SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL DLSQTASPAA NRPNGMRLTN
510 520 530 540 550
GHSTTPVPAT TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK TAIQFKQHHQ
560 570 580 590 600
QSQQNGFQLG TGKFQDTAKP PLVGAHAKGE ANPAPTANGN KSSSTSSNNS
610 620 630 640 650
SSSNHKSINQ QQYLPISSED EDSEDERTSR PSTVQLPSMP KMTDDHTEKP
660 670 680 690 700
KSPVKIQAKT PIKTPLKSLV PYESASEEEE APLPNPRKRR SGEDSSESDQ
710 720 730 740 750
ESGQTNGHSK TNGSLTNGSA SSSVHVNNSK LKTDAIDEIF KSLKKSADSD
760 770 780 790 800
DDDDEEESSI QLTNGWHPQK QSQSQSKAPP SPKTPPSPAV IKSKTGIWKV
810 820 830 840 850
TRNDEVDDID DDDDEEEEAT VKIQTPSKTH RNPFSSSKPS TDSPATPGAK
860 870 880 890 900
RQKLLNGSPV KSHQQPRVGN GYQSEATSNG STINELLKQS HRGYGSSVLS
910 920 930 940 950
WNGKPAELEK ETFELVCAKR IAGHGSVDGS DIVESSVAVN ASSGSDSNDV
960 970 980 990 1000
VVIAVALLVD AREQRQRDLD DDEENEMDRG RQRKVKSGSA KGNNASNSTP
1010 1020 1030 1040 1050
GYNPFQEYEG QKRWNKNGGG GGGFPRFYNQ NFRQNFQQRN KFKFNRFGGP
1060 1070 1080
GGAKFQQQRA LQRHLAAGGG FSRRQPSAQQ QQQQS
Length:1,085
Mass (Da):118,856
Last modified:September 2, 2008 - v1
Checksum:i5C90048688306DA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954178 Genomic DNA. Translation: EDV51044.1.
RefSeqiXP_001972018.2. XM_001971982.2.

Genome annotation databases

EnsemblMetazoaiFBtr0135339; FBpp0133831; FBgn0107537.
GeneIDi6544695.
KEGGider:Dere_GG15285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954178 Genomic DNA. Translation: EDV51044.1.
RefSeqiXP_001972018.2. XM_001971982.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0135339; FBpp0133831; FBgn0107537.
GeneIDi6544695.
KEGGider:Dere_GG15285.

Organism-specific databases

FlyBaseiFBgn0107537. Dere\GG15285.

Phylogenomic databases

KOiK11855.
OMAiSKYIVIK.
OrthoDBiEOG091G06D5.
PhylomeDBiB3NC86.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP36_DROER
AccessioniPrimary (citable) accession number: B3NC86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.