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B3NC86

- UBP36_DROER

UniProt

B3NC86 - UBP36_DROER

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821NucleophilePROSITE-ProRule annotation
Active sitei440 – 4401Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GG15285
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0107537. Dere\GG15285.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10851085Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei514 – 5141PhosphoserineBy similarity
Modified residuei516 – 5161PhosphoserineBy similarity
Modified residuei660 – 6601PhosphothreonineBy similarity
Modified residuei664 – 6641PhosphothreonineBy similarity
Modified residuei674 – 6741PhosphoserineBy similarity
Modified residuei676 – 6761PhosphoserineBy similarity
Modified residuei749 – 7491PhosphoserineBy similarity
Modified residuei781 – 7811PhosphoserineBy similarity
Modified residuei784 – 7841PhosphothreonineBy similarity
Modified residuei787 – 7871PhosphoserineBy similarity
Modified residuei825 – 8251PhosphothreonineBy similarity
Modified residuei843 – 8431PhosphoserineBy similarity
Modified residuei846 – 8461PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 481309USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB3NC86.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3NC86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSMAVCET ANVVNAALRE SLGGNSSAAG SSADQAKSGE ESNGSLQNHI
60 70 80 90 100
VANAKRILMA KIEYEEVPNY HESVLESLKS KYIVIKPGNP GAINGFGGKN
110 120 130 140 150
NTGKVVGANG HDNNGARKQA EHPNNQSHHN NHNNHPHPTS NPNELPKPKR
160 170 180 190 200
VLYPRENIRI GWKQSERKWQ VGTGMINVGN TCYLNSTLQA LLHIPALANW
210 220 230 240 250
LVSEQAHLEN CNVAESGGGC IVCAMAKTLL ATQSNQSAVR PFLIYSKLKQ
260 270 280 290 300
ICKHMVVGRQ EDAHEFLRFL VEAMERAYLM RFRNYKELDQ LVKETTPLGQ
310 320 330 340 350
IFGGYLRSEV RCLSCNHVSI TFQHFQDLLL DIRKADTLED AFEGHFSRER
360 370 380 390 400
LEDMGYKCEG CKKKVSATKQ FSLERAPITL CIQLKRFSMI GNKLTKQISF
410 420 430 440 450
KPRIDLSKYA ARSPAAQAQP LTYRLVSMVT HLGVSQHCGH YTAIGSTDTG
460 470 480 490 500
SYYNFDDSYV RPIAMQSVCN TNAYIMFYEL DLSQTASPAA NRPNGMRLTN
510 520 530 540 550
GHSTTPVPAT TVSSPSPTRF IGPQLPPGGV NGYSNGNAQK TAIQFKQHHQ
560 570 580 590 600
QSQQNGFQLG TGKFQDTAKP PLVGAHAKGE ANPAPTANGN KSSSTSSNNS
610 620 630 640 650
SSSNHKSINQ QQYLPISSED EDSEDERTSR PSTVQLPSMP KMTDDHTEKP
660 670 680 690 700
KSPVKIQAKT PIKTPLKSLV PYESASEEEE APLPNPRKRR SGEDSSESDQ
710 720 730 740 750
ESGQTNGHSK TNGSLTNGSA SSSVHVNNSK LKTDAIDEIF KSLKKSADSD
760 770 780 790 800
DDDDEEESSI QLTNGWHPQK QSQSQSKAPP SPKTPPSPAV IKSKTGIWKV
810 820 830 840 850
TRNDEVDDID DDDDEEEEAT VKIQTPSKTH RNPFSSSKPS TDSPATPGAK
860 870 880 890 900
RQKLLNGSPV KSHQQPRVGN GYQSEATSNG STINELLKQS HRGYGSSVLS
910 920 930 940 950
WNGKPAELEK ETFELVCAKR IAGHGSVDGS DIVESSVAVN ASSGSDSNDV
960 970 980 990 1000
VVIAVALLVD AREQRQRDLD DDEENEMDRG RQRKVKSGSA KGNNASNSTP
1010 1020 1030 1040 1050
GYNPFQEYEG QKRWNKNGGG GGGFPRFYNQ NFRQNFQQRN KFKFNRFGGP
1060 1070 1080
GGAKFQQQRA LQRHLAAGGG FSRRQPSAQQ QQQQS
Length:1,085
Mass (Da):118,856
Last modified:September 2, 2008 - v1
Checksum:i5C90048688306DA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954178 Genomic DNA. Translation: EDV51044.1.
RefSeqiXP_001972018.1. XM_001971982.1.

Genome annotation databases

EnsemblMetazoaiFBtr0135339; FBpp0133831; FBgn0107537.
GeneIDi6544695.
KEGGider:Dere_GG15285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954178 Genomic DNA. Translation: EDV51044.1 .
RefSeqi XP_001972018.1. XM_001971982.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0135339 ; FBpp0133831 ; FBgn0107537 .
GeneIDi 6544695.
KEGGi der:Dere_GG15285.

Organism-specific databases

FlyBasei FBgn0107537. Dere\GG15285.

Phylogenomic databases

KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B3NC86.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiUBP36_DROER
AccessioniPrimary (citable) accession number: B3NC86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3