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B3MYY4

- TRMB_DROAN

UniProt

B3MYY4 - TRMB_DROAN

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

GF21935

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei158 – 1581S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei161 – 1611UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:GF21935
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0098935. Dana\GF21935.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257tRNA (guanine-N(7)-)-methyltransferasePRO_0000370568Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0125127.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni103 – 1042S-adenosyl-L-methionine bindingUniRule annotation
Regioni138 – 1392S-adenosyl-L-methionine bindingUniRule annotation
Regioni236 – 2383S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
InParanoidiB3MYY4.
KOiK03439.
OrthoDBiEOG7PS1GC.
PhylomeDBiB3MYY4.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3MYY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARDSEDQDM ETETNGAAEG LDPTSAVTGL PQKRFYRQRA HSNPIADHSF
60 70 80 90 100
DYPARPEDVN WRALYPSIQP DQKVTFADIG CGYGGFLVTL GEMFPEKFSI
110 120 130 140 150
GMEIRVKVSD YVMDRITALR HKSGEAGAYK NIACLRTNAM KYLPNYFAKG
160 170 180 190 200
QLEKMFFLYP DPHFKRAKHK WRIINQALLS EYAYVLKKGG LVYTMTDVED
210 220 230 240 250
LHQWIVQHME EHPLYERLKE EEEQSDPITP KLYQSSEEGA KVVRNKGDHF

LAIFRRL
Length:257
Mass (Da):29,691
Last modified:September 2, 2008 - v1
Checksum:i33BE80F4FBCCC529
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902632 Genomic DNA. Translation: EDV32828.1.
RefSeqiXP_001966540.1. XM_001966504.1.

Genome annotation databases

EnsemblMetazoaiFBtr0126635; FBpp0125127; FBgn0098935.
GeneIDi6504605.
KEGGidan:Dana_GF21935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902632 Genomic DNA. Translation: EDV32828.1 .
RefSeqi XP_001966540.1. XM_001966504.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0125127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0126635 ; FBpp0125127 ; FBgn0098935 .
GeneIDi 6504605.
KEGGi dan:Dana_GF21935.

Organism-specific databases

FlyBasei FBgn0098935. Dana\GF21935.

Phylogenomic databases

eggNOGi COG0220.
InParanoidi B3MYY4.
KOi K03439.
OrthoDBi EOG7PS1GC.
PhylomeDBi B3MYY4.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiTRMB_DROAN
AccessioniPrimary (citable) accession number: B3MYY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3