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B3MYY4

- TRMB_DROAN

UniProt

B3MYY4 - TRMB_DROAN

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

GF21935

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei158 – 1581S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Active sitei161 – 1611UniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
    2. tRNA binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine, tRNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:GF21935
    OrganismiDrosophila ananassae (Fruit fly)
    Taxonomic identifieri7217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007801: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0098935. Dana\GF21935.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257tRNA (guanine-N(7)-)-methyltransferasePRO_0000370568Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7217.FBpp0125127.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni103 – 1042S-adenosyl-L-methionine bindingUniRule annotation
    Regioni138 – 1392S-adenosyl-L-methionine bindingUniRule annotation
    Regioni236 – 2383S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    InParanoidiB3MYY4.
    KOiK03439.
    OrthoDBiEOG7PS1GC.
    PhylomeDBiB3MYY4.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3MYY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARDSEDQDM ETETNGAAEG LDPTSAVTGL PQKRFYRQRA HSNPIADHSF    50
    DYPARPEDVN WRALYPSIQP DQKVTFADIG CGYGGFLVTL GEMFPEKFSI 100
    GMEIRVKVSD YVMDRITALR HKSGEAGAYK NIACLRTNAM KYLPNYFAKG 150
    QLEKMFFLYP DPHFKRAKHK WRIINQALLS EYAYVLKKGG LVYTMTDVED 200
    LHQWIVQHME EHPLYERLKE EEEQSDPITP KLYQSSEEGA KVVRNKGDHF 250
    LAIFRRL 257
    Length:257
    Mass (Da):29,691
    Last modified:September 2, 2008 - v1
    Checksum:i33BE80F4FBCCC529
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902632 Genomic DNA. Translation: EDV32828.1.
    RefSeqiXP_001966540.1. XM_001966504.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0126635; FBpp0125127; FBgn0098935.
    GeneIDi6504605.
    KEGGidan:Dana_GF21935.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902632 Genomic DNA. Translation: EDV32828.1 .
    RefSeqi XP_001966540.1. XM_001966504.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7217.FBpp0125127.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0126635 ; FBpp0125127 ; FBgn0098935 .
    GeneIDi 6504605.
    KEGGi dan:Dana_GF21935.

    Organism-specific databases

    FlyBasei FBgn0098935. Dana\GF21935.

    Phylogenomic databases

    eggNOGi COG0220.
    InParanoidi B3MYY4.
    KOi K03439.
    OrthoDBi EOG7PS1GC.
    PhylomeDBi B3MYY4.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14024-0371.13.

    Entry informationi

    Entry nameiTRMB_DROAN
    AccessioniPrimary (citable) accession number: B3MYY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3