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B3MRI9 (SWS_DROAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese
EC=3.1.1.5
Gene names
Name:sws
ORF Names:GF20991
OrganismDrosophila ananassae (Fruit fly) [Complete proteome]
Taxonomic identifier7217 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1514 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity. UniProtKB Q9U969

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. UniProtKB Q9U969

Subunit structure

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity. UniProtKB Q9U969

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Sws tethers Pka-C3 to the membrane By similarity. UniProtKB Q9U969

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15141514Neuropathy target esterase sws
PRO_0000389220

Regions

Topological domain1 – 3434Lumenal Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 15141459Cytoplasmic Potential
Domain987 – 1153167Patatin
Nucleotide binding175 – 302128cNMP 1
Nucleotide binding515 – 644130cNMP 2
Nucleotide binding633 – 760128cNMP 3

Sites

Active site10201 By similarity UniProtKB Q9U969

Amino acid modifications

Modified residue4571Phosphoserine By similarity UniProtKB Q9U969
Modified residue12341Phosphoserine By similarity UniProtKB Q9U969

Sequences

Sequence LengthMass (Da)Tools
B3MRI9 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: FB75DE6E3CB5E827

FASTA1,514169,508
        10         20         30         40         50         60 
MDVLELLRAS ATGSYTALFS DAWCQYVSKQ ITNSMYLYCA LGVLSMVFLA WFMYFKRLAR 

        70         80         90        100        110        120 
IRLRDEASRS MSAVNSSSGG DLRGLRFRKR DKMLFYGRRM LRKMKNVSGQ MYSSGKGYKR 

       130        140        150        160        170        180 
RAVMRFARRI LQLRRDNMPL EMRTVEPPAE YLEETIDGSD RVPPDALYML QSIRIFGHFE 

       190        200        210        220        230        240 
KPVFLRLCKH TQLLELMAGD YLFKITDPDD SVYIVQSGMI NVYISNADGS TLSLKTVRKG 

       250        260        270        280        290        300 
ESVTSLLSFI DVLSGNPSYY KTVTAKAIEK SVVIRLPMEA FEEVFQDNPD VMIRVIQVIM 

       310        320        330        340        350        360 
IRLQRVLFTA LRNYLGLNAE LVQNHMRFKS STIMAPSTHS SQCSRQTGSQ PTLGVPAPTC 

       370        380        390        400        410        420 
SNTTTTASPT TANTVHSGLA GANGVIGQSR PPISPSRHSR EEHTLSDPNP NPDVINTSVG 

       430        440        450        460        470        480 
GASGTSMYAE VHGDAPNVDV FHQQQHSVGN LSTRRGSISQ MAPDLGPALS QPGLGQGQGL 

       490        500        510        520        530        540 
GPGVTGAPPL MTGAPASKID MRLVHASAVD SLRKELGLPE EDSHIIEPFV EVRELEPNVT 

       550        560        570        580        590        600 
LITEGNSDDV CVWFVMTGTL AVYQANQDAA RAKQQQEKND MLIHFVHPGE IVGGLAMLTG 

       610        620        630        640        650        660 
EASAYTIRSR NNSRVAFIRR AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR QCDYALDWIF 

       670        680        690        700        710        720 
LESGRAVYRQ DEISDSTYIV LSGRMRSVIT HPGGKKEIIG EYGKGDLVGI VEMITETSRT 

       730        740        750        760        770        780 
TTVLAVRDSE LAKLPEGLFN AIKLRYPIVV TKLISFLSHR FLGTMQTRSS SAAPGGPVEA 

       790        800        810        820        830        840 
NPVTHKYSTV ALVPITDEVP LTPFTYELYH SLCAIGPVLR LTSDVVRKQL GPNIFEAANE 

       850        860        870        880        890        900 
YRLTSWLAQQ EDRNIITLYQ CDNALSAWTQ RCMRQADVIL IVGLGNGSHL VGKFEREIDR 

       910        920        930        940        950        960 
LAMRTQKELV LLYPETTNSK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS 

       970        980        990       1000       1010       1020 
RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG IPIDMVGGVS 

      1030       1040       1050       1060       1070       1080 
IGALMGALWC SERNITTVTQ KAREWSKKMT KWFLQLLDLT YPITSMFSGR EFNKTIHDTF 

      1090       1100       1110       1120       1130       1140 
GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG SLWRYVRSSM SLSGYMPPLC DPKDGHLLLD 

      1150       1160       1170       1180       1190       1200 
GGYVNNLPGQ LWRYCRASMS IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII 

      1210       1220       1230       1240       1250       1260 
AIDVGSQDDT DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV 

      1270       1280       1290       1300       1310       1320 
KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE NMAKAGRLGR FNQWFNKEPP 

      1330       1340       1350       1360       1370       1380 
KRGNHASLNE YTFIDLAQIV CRLPETNAGN SADIFSEDED CDGYISEPTT LNTDRRRIQV 

      1390       1400       1410       1420       1430       1440 
PRAGNSLSFS ENEMDSDVEL DLQLDRKTEK SIHSAATSVA RGSMRSREFH KLEQDRSVEI 

      1450       1460       1470       1480       1490       1500 
TRLKDETERI MAPTNLDRKG DGQEQEKEPE QEQELETEEP NQENTEVEEE QRNQGEGNED 

      1510 
NKENKGGAYN ETKN 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14024-0371.13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH902622 Genomic DNA. Translation: EDV34394.1.
RefSeqXP_001963945.1. XM_001963909.1.

3D structure databases

ProteinModelPortalB3MRI9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7217.FBpp0124183.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0125691; FBpp0124183; FBgn0097996.
GeneID6503680.
KEGGdan:Dana_GF20991.

Organism-specific databases

FlyBaseFBgn0097996. Dana\GF20991.

Phylogenomic databases

eggNOGCOG0664.
InParanoidB3MRI9.
KOK14676.
OrthoDBEOG7QRQT1.
PhylomeDBB3MRI9.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSWS_DROAN
AccessionPrimary (citable) accession number: B3MRI9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase