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B3MRI9

- SWS_DROAN

UniProt

B3MRI9 - SWS_DROAN

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1020 – 10201By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 302128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi515 – 644130cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi633 – 760128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GF20991
    OrganismiDrosophila ananassae (Fruit fly)
    Taxonomic identifieri7217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007801: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0097996. Dana\GF20991.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15141514Neuropathy target esterase swsPRO_0000389220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei457 – 4571PhosphoserineBy similarity
    Modified residuei1234 – 12341PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Protein-protein interaction databases

    STRINGi7217.FBpp0124183.

    Structurei

    3D structure databases

    ProteinModelPortaliB3MRI9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 15141459CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini987 – 1153167PatatinSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    InParanoidiB3MRI9.
    KOiK14676.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB3MRI9.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3MRI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLELLRAS ATGSYTALFS DAWCQYVSKQ ITNSMYLYCA LGVLSMVFLA     50
    WFMYFKRLAR IRLRDEASRS MSAVNSSSGG DLRGLRFRKR DKMLFYGRRM 100
    LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLRRDNMPL EMRTVEPPAE 150
    YLEETIDGSD RVPPDALYML QSIRIFGHFE KPVFLRLCKH TQLLELMAGD 200
    YLFKITDPDD SVYIVQSGMI NVYISNADGS TLSLKTVRKG ESVTSLLSFI 250
    DVLSGNPSYY KTVTAKAIEK SVVIRLPMEA FEEVFQDNPD VMIRVIQVIM 300
    IRLQRVLFTA LRNYLGLNAE LVQNHMRFKS STIMAPSTHS SQCSRQTGSQ 350
    PTLGVPAPTC SNTTTTASPT TANTVHSGLA GANGVIGQSR PPISPSRHSR 400
    EEHTLSDPNP NPDVINTSVG GASGTSMYAE VHGDAPNVDV FHQQQHSVGN 450
    LSTRRGSISQ MAPDLGPALS QPGLGQGQGL GPGVTGAPPL MTGAPASKID 500
    MRLVHASAVD SLRKELGLPE EDSHIIEPFV EVRELEPNVT LITEGNSDDV 550
    CVWFVMTGTL AVYQANQDAA RAKQQQEKND MLIHFVHPGE IVGGLAMLTG 600
    EASAYTIRSR NNSRVAFIRR AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR 650
    QCDYALDWIF LESGRAVYRQ DEISDSTYIV LSGRMRSVIT HPGGKKEIIG 700
    EYGKGDLVGI VEMITETSRT TTVLAVRDSE LAKLPEGLFN AIKLRYPIVV 750
    TKLISFLSHR FLGTMQTRSS SAAPGGPVEA NPVTHKYSTV ALVPITDEVP 800
    LTPFTYELYH SLCAIGPVLR LTSDVVRKQL GPNIFEAANE YRLTSWLAQQ 850
    EDRNIITLYQ CDNALSAWTQ RCMRQADVIL IVGLGNGSHL VGKFEREIDR 900
    LAMRTQKELV LLYPETTNSK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK 950
    SQYRINDLYS RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI 1000
    GMLKAIQEAG IPIDMVGGVS IGALMGALWC SERNITTVTQ KAREWSKKMT 1050
    KWFLQLLDLT YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT 1100
    ASCHRIHTNG SLWRYVRSSM SLSGYMPPLC DPKDGHLLLD GGYVNNLPGQ 1150
    LWRYCRASMS IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII 1200
    AIDVGSQDDT DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY 1250
    VSCVRQLEEV KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE 1300
    NMAKAGRLGR FNQWFNKEPP KRGNHASLNE YTFIDLAQIV CRLPETNAGN 1350
    SADIFSEDED CDGYISEPTT LNTDRRRIQV PRAGNSLSFS ENEMDSDVEL 1400
    DLQLDRKTEK SIHSAATSVA RGSMRSREFH KLEQDRSVEI TRLKDETERI 1450
    MAPTNLDRKG DGQEQEKEPE QEQELETEEP NQENTEVEEE QRNQGEGNED 1500
    NKENKGGAYN ETKN 1514
    Length:1,514
    Mass (Da):169,508
    Last modified:September 2, 2008 - v1
    Checksum:iFB75DE6E3CB5E827
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902622 Genomic DNA. Translation: EDV34394.1.
    RefSeqiXP_001963945.1. XM_001963909.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0125691; FBpp0124183; FBgn0097996.
    GeneIDi6503680.
    KEGGidan:Dana_GF20991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902622 Genomic DNA. Translation: EDV34394.1 .
    RefSeqi XP_001963945.1. XM_001963909.1.

    3D structure databases

    ProteinModelPortali B3MRI9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7217.FBpp0124183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0125691 ; FBpp0124183 ; FBgn0097996 .
    GeneIDi 6503680.
    KEGGi dan:Dana_GF20991.

    Organism-specific databases

    FlyBasei FBgn0097996. Dana\GF20991.

    Phylogenomic databases

    eggNOGi COG0664.
    InParanoidi B3MRI9.
    KOi K14676.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B3MRI9.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14024-0371.13Imported.

    Entry informationi

    Entry nameiSWS_DROAN
    AccessioniPrimary (citable) accession number: B3MRI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3