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B3MRI9

- SWS_DROAN

UniProt

B3MRI9 - SWS_DROAN

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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1020 – 10201By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 302128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi515 – 644130cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi633 – 760128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GF20991
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0097996. Dana\GF20991.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Topological domaini56 – 15141459CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15141514Neuropathy target esterase swsPRO_0000389220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei457 – 4571PhosphoserineBy similarity
Modified residuei1234 – 12341PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0124183.

Structurei

3D structure databases

ProteinModelPortaliB3MRI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini987 – 1153167PatatinSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB3MRI9.
KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB3MRI9.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3MRI9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLELLRAS ATGSYTALFS DAWCQYVSKQ ITNSMYLYCA LGVLSMVFLA
60 70 80 90 100
WFMYFKRLAR IRLRDEASRS MSAVNSSSGG DLRGLRFRKR DKMLFYGRRM
110 120 130 140 150
LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLRRDNMPL EMRTVEPPAE
160 170 180 190 200
YLEETIDGSD RVPPDALYML QSIRIFGHFE KPVFLRLCKH TQLLELMAGD
210 220 230 240 250
YLFKITDPDD SVYIVQSGMI NVYISNADGS TLSLKTVRKG ESVTSLLSFI
260 270 280 290 300
DVLSGNPSYY KTVTAKAIEK SVVIRLPMEA FEEVFQDNPD VMIRVIQVIM
310 320 330 340 350
IRLQRVLFTA LRNYLGLNAE LVQNHMRFKS STIMAPSTHS SQCSRQTGSQ
360 370 380 390 400
PTLGVPAPTC SNTTTTASPT TANTVHSGLA GANGVIGQSR PPISPSRHSR
410 420 430 440 450
EEHTLSDPNP NPDVINTSVG GASGTSMYAE VHGDAPNVDV FHQQQHSVGN
460 470 480 490 500
LSTRRGSISQ MAPDLGPALS QPGLGQGQGL GPGVTGAPPL MTGAPASKID
510 520 530 540 550
MRLVHASAVD SLRKELGLPE EDSHIIEPFV EVRELEPNVT LITEGNSDDV
560 570 580 590 600
CVWFVMTGTL AVYQANQDAA RAKQQQEKND MLIHFVHPGE IVGGLAMLTG
610 620 630 640 650
EASAYTIRSR NNSRVAFIRR AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR
660 670 680 690 700
QCDYALDWIF LESGRAVYRQ DEISDSTYIV LSGRMRSVIT HPGGKKEIIG
710 720 730 740 750
EYGKGDLVGI VEMITETSRT TTVLAVRDSE LAKLPEGLFN AIKLRYPIVV
760 770 780 790 800
TKLISFLSHR FLGTMQTRSS SAAPGGPVEA NPVTHKYSTV ALVPITDEVP
810 820 830 840 850
LTPFTYELYH SLCAIGPVLR LTSDVVRKQL GPNIFEAANE YRLTSWLAQQ
860 870 880 890 900
EDRNIITLYQ CDNALSAWTQ RCMRQADVIL IVGLGNGSHL VGKFEREIDR
910 920 930 940 950
LAMRTQKELV LLYPETTNSK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK
960 970 980 990 1000
SQYRINDLYS RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI
1010 1020 1030 1040 1050
GMLKAIQEAG IPIDMVGGVS IGALMGALWC SERNITTVTQ KAREWSKKMT
1060 1070 1080 1090 1100
KWFLQLLDLT YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT
1110 1120 1130 1140 1150
ASCHRIHTNG SLWRYVRSSM SLSGYMPPLC DPKDGHLLLD GGYVNNLPGQ
1160 1170 1180 1190 1200
LWRYCRASMS IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII
1210 1220 1230 1240 1250
AIDVGSQDDT DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY
1260 1270 1280 1290 1300
VSCVRQLEEV KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE
1310 1320 1330 1340 1350
NMAKAGRLGR FNQWFNKEPP KRGNHASLNE YTFIDLAQIV CRLPETNAGN
1360 1370 1380 1390 1400
SADIFSEDED CDGYISEPTT LNTDRRRIQV PRAGNSLSFS ENEMDSDVEL
1410 1420 1430 1440 1450
DLQLDRKTEK SIHSAATSVA RGSMRSREFH KLEQDRSVEI TRLKDETERI
1460 1470 1480 1490 1500
MAPTNLDRKG DGQEQEKEPE QEQELETEEP NQENTEVEEE QRNQGEGNED
1510
NKENKGGAYN ETKN
Length:1,514
Mass (Da):169,508
Last modified:September 2, 2008 - v1
Checksum:iFB75DE6E3CB5E827
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902622 Genomic DNA. Translation: EDV34394.1.
RefSeqiXP_001963945.1. XM_001963909.1.

Genome annotation databases

EnsemblMetazoaiFBtr0125691; FBpp0124183; FBgn0097996.
GeneIDi6503680.
KEGGidan:Dana_GF20991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902622 Genomic DNA. Translation: EDV34394.1 .
RefSeqi XP_001963945.1. XM_001963909.1.

3D structure databases

ProteinModelPortali B3MRI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0124183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0125691 ; FBpp0124183 ; FBgn0097996 .
GeneIDi 6503680.
KEGGi dan:Dana_GF20991.

Organism-specific databases

FlyBasei FBgn0097996. Dana\GF20991.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B3MRI9.
KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B3MRI9.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13Imported.

Entry informationi

Entry nameiSWS_DROAN
AccessioniPrimary (citable) accession number: B3MRI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3