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B3MRI9

- SWS_DROAN

UniProt

B3MRI9 - SWS_DROAN

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Protein

Neuropathy target esterase sws

Gene
sws, GF20991
Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1020 – 10201 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 302128cNMP 1Add
BLAST
Nucleotide bindingi515 – 644130cNMP 2Add
BLAST
Nucleotide bindingi633 – 760128cNMP 3Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GF20991
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0097996. Dana\GF20991.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Topological domaini56 – 15141459Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15141514Neuropathy target esterase swsPRO_0000389220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei457 – 4571Phosphoserine By similarityBy similarity
Modified residuei1234 – 12341Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0124183.

Structurei

3D structure databases

ProteinModelPortaliB3MRI9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini987 – 1153167PatatinAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB3MRI9.
KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB3MRI9.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3MRI9-1 [UniParc]FASTAAdd to Basket

« Hide

MDVLELLRAS ATGSYTALFS DAWCQYVSKQ ITNSMYLYCA LGVLSMVFLA     50
WFMYFKRLAR IRLRDEASRS MSAVNSSSGG DLRGLRFRKR DKMLFYGRRM 100
LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLRRDNMPL EMRTVEPPAE 150
YLEETIDGSD RVPPDALYML QSIRIFGHFE KPVFLRLCKH TQLLELMAGD 200
YLFKITDPDD SVYIVQSGMI NVYISNADGS TLSLKTVRKG ESVTSLLSFI 250
DVLSGNPSYY KTVTAKAIEK SVVIRLPMEA FEEVFQDNPD VMIRVIQVIM 300
IRLQRVLFTA LRNYLGLNAE LVQNHMRFKS STIMAPSTHS SQCSRQTGSQ 350
PTLGVPAPTC SNTTTTASPT TANTVHSGLA GANGVIGQSR PPISPSRHSR 400
EEHTLSDPNP NPDVINTSVG GASGTSMYAE VHGDAPNVDV FHQQQHSVGN 450
LSTRRGSISQ MAPDLGPALS QPGLGQGQGL GPGVTGAPPL MTGAPASKID 500
MRLVHASAVD SLRKELGLPE EDSHIIEPFV EVRELEPNVT LITEGNSDDV 550
CVWFVMTGTL AVYQANQDAA RAKQQQEKND MLIHFVHPGE IVGGLAMLTG 600
EASAYTIRSR NNSRVAFIRR AAIYQIMRQR PRIVLDLGNG VVRRLSPLVR 650
QCDYALDWIF LESGRAVYRQ DEISDSTYIV LSGRMRSVIT HPGGKKEIIG 700
EYGKGDLVGI VEMITETSRT TTVLAVRDSE LAKLPEGLFN AIKLRYPIVV 750
TKLISFLSHR FLGTMQTRSS SAAPGGPVEA NPVTHKYSTV ALVPITDEVP 800
LTPFTYELYH SLCAIGPVLR LTSDVVRKQL GPNIFEAANE YRLTSWLAQQ 850
EDRNIITLYQ CDNALSAWTQ RCMRQADVIL IVGLGNGSHL VGKFEREIDR 900
LAMRTQKELV LLYPETTNSK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK 950
SQYRINDLYS RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI 1000
GMLKAIQEAG IPIDMVGGVS IGALMGALWC SERNITTVTQ KAREWSKKMT 1050
KWFLQLLDLT YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT 1100
ASCHRIHTNG SLWRYVRSSM SLSGYMPPLC DPKDGHLLLD GGYVNNLPGQ 1150
LWRYCRASMS IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII 1200
AIDVGSQDDT DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY 1250
VSCVRQLEEV KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFE 1300
NMAKAGRLGR FNQWFNKEPP KRGNHASLNE YTFIDLAQIV CRLPETNAGN 1350
SADIFSEDED CDGYISEPTT LNTDRRRIQV PRAGNSLSFS ENEMDSDVEL 1400
DLQLDRKTEK SIHSAATSVA RGSMRSREFH KLEQDRSVEI TRLKDETERI 1450
MAPTNLDRKG DGQEQEKEPE QEQELETEEP NQENTEVEEE QRNQGEGNED 1500
NKENKGGAYN ETKN 1514
Length:1,514
Mass (Da):169,508
Last modified:September 2, 2008 - v1
Checksum:iFB75DE6E3CB5E827
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902622 Genomic DNA. Translation: EDV34394.1.
RefSeqiXP_001963945.1. XM_001963909.1.

Genome annotation databases

EnsemblMetazoaiFBtr0125691; FBpp0124183; FBgn0097996.
GeneIDi6503680.
KEGGidan:Dana_GF20991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902622 Genomic DNA. Translation: EDV34394.1 .
RefSeqi XP_001963945.1. XM_001963909.1.

3D structure databases

ProteinModelPortali B3MRI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0124183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0125691 ; FBpp0124183 ; FBgn0097996 .
GeneIDi 6503680.
KEGGi dan:Dana_GF20991.

Organism-specific databases

FlyBasei FBgn0097996. Dana\GF20991.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B3MRI9.
KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B3MRI9.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiSWS_DROAN
AccessioniPrimary (citable) accession number: B3MRI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi