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B3MR30

- PGAM5_DROAN

UniProt

B3MR30 - PGAM5_DROAN

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Protein
Serine/threonine-protein phosphatase Pgam5, mitochondrial
Gene
Pgam5, GF21073
Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene namesi
Name:Pgam5
ORF Names:GF21073
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0098078. Dana\GF21073.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000390703Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1 By similarity.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0124265.

Structurei

3D structure databases

ProteinModelPortaliB3MR30.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71348.
InParanoidiB3MR30.
KOiK15637.
OrthoDBiEOG7966H1.
PhylomeDBiB3MR30.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

B3MR30-1 [UniParc]FASTAAdd to Basket

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MRKLSSLVCG AGAGLAAFYL SRLRDPQKAA HSSWTNSEKP VDACGLWDSN    50
WDCRDPRLMV RPLKNTQPEE ENRFNADLEK AKPKKARHII LVRHGEYLDV 100
GESDATHHLT ERGRKQAQFT GQRLSELGIQ WDKVIASTMV RAQETADIIL 150
KEIKYDKEKV VNCVYLREGA PIPPQPPVGH WKPEASQFYR DGARIEAAFR 200
RYFHRAYPDQ DKESYTLIVG HGNVIRYFVC RALQFPPEGW LRISINHASI 250
TWLTISPSGN VSIKYLGDSG FMPVQYLTNR IPRDAKNVV 289
Length:289
Mass (Da):32,959
Last modified:September 2, 2008 - v1
Checksum:iD477D3D60F0A71E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902622 Genomic DNA. Translation: EDV34235.1.
RefSeqiXP_001963786.1. XM_001963750.1.

Genome annotation databases

EnsemblMetazoaiFBtr0125773; FBpp0124265; FBgn0098078.
GeneIDi6503762.
KEGGidan:Dana_GF21073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902622 Genomic DNA. Translation: EDV34235.1 .
RefSeqi XP_001963786.1. XM_001963750.1.

3D structure databases

ProteinModelPortali B3MR30.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0124265.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0125773 ; FBpp0124265 ; FBgn0098078 .
GeneIDi 6503762.
KEGGi dan:Dana_GF21073.

Organism-specific databases

FlyBasei FBgn0098078. Dana\GF21073.

Phylogenomic databases

eggNOGi NOG71348.
InParanoidi B3MR30.
KOi K15637.
OrthoDBi EOG7966H1.
PhylomeDBi B3MR30.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiPGAM5_DROAN
AccessioniPrimary (citable) accession number: B3MR30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi