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B3MR30 (PGAM5_DROAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene names
Name:Pgam5
ORF Names:GF21073
OrganismDrosophila ananassae (Fruit fly) [Complete proteome]
Taxonomic identifier7217 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity. UniProtKB O46084

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with Pk92B/ASK1 By similarity. UniProtKB O46084

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000390703

Regions

Transmembrane7 – 2317Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B3MR30 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: D477D3D60F0A71E5

FASTA28932,959
        10         20         30         40         50         60 
MRKLSSLVCG AGAGLAAFYL SRLRDPQKAA HSSWTNSEKP VDACGLWDSN WDCRDPRLMV 

        70         80         90        100        110        120 
RPLKNTQPEE ENRFNADLEK AKPKKARHII LVRHGEYLDV GESDATHHLT ERGRKQAQFT 

       130        140        150        160        170        180 
GQRLSELGIQ WDKVIASTMV RAQETADIIL KEIKYDKEKV VNCVYLREGA PIPPQPPVGH 

       190        200        210        220        230        240 
WKPEASQFYR DGARIEAAFR RYFHRAYPDQ DKESYTLIVG HGNVIRYFVC RALQFPPEGW 

       250        260        270        280 
LRISINHASI TWLTISPSGN VSIKYLGDSG FMPVQYLTNR IPRDAKNVV 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14024-0371.13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH902622 Genomic DNA. Translation: EDV34235.1.
RefSeqXP_001963786.1. XM_001963750.1.

3D structure databases

ProteinModelPortalB3MR30.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7217.FBpp0124265.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0125773; FBpp0124265; FBgn0098078.
GeneID6503762.
KEGGdan:Dana_GF21073.

Organism-specific databases

FlyBaseFBgn0098078. Dana\GF21073.

Phylogenomic databases

eggNOGNOG71348.
InParanoidB3MR30.
KOK15637.
OrthoDBEOG7966H1.
PhylomeDBB3MR30.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGAM5_DROAN
AccessionPrimary (citable) accession number: B3MR30
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase