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B3MR30

- PGAM5_DROAN

UniProt

B3MR30 - PGAM5_DROAN

Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5 homologBy similarity
    Gene namesi
    Name:Pgam5By similarity
    ORF Names:GF21073
    OrganismiDrosophila ananassae (Fruit fly)
    Taxonomic identifieri7217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007801: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0098078. Dana\GF21073.

    Subcellular locationi

    Mitochondrion outer membrane By similaritySequence Analysis; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390703Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with Pk92B/ASK1.By similarity

    Protein-protein interaction databases

    STRINGi7217.FBpp0124265.

    Structurei

    3D structure databases

    ProteinModelPortaliB3MR30.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71348.
    InParanoidiB3MR30.
    KOiK15637.
    OrthoDBiEOG7966H1.
    PhylomeDBiB3MR30.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B3MR30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKLSSLVCG AGAGLAAFYL SRLRDPQKAA HSSWTNSEKP VDACGLWDSN    50
    WDCRDPRLMV RPLKNTQPEE ENRFNADLEK AKPKKARHII LVRHGEYLDV 100
    GESDATHHLT ERGRKQAQFT GQRLSELGIQ WDKVIASTMV RAQETADIIL 150
    KEIKYDKEKV VNCVYLREGA PIPPQPPVGH WKPEASQFYR DGARIEAAFR 200
    RYFHRAYPDQ DKESYTLIVG HGNVIRYFVC RALQFPPEGW LRISINHASI 250
    TWLTISPSGN VSIKYLGDSG FMPVQYLTNR IPRDAKNVV 289
    Length:289
    Mass (Da):32,959
    Last modified:September 2, 2008 - v1
    Checksum:iD477D3D60F0A71E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902622 Genomic DNA. Translation: EDV34235.1.
    RefSeqiXP_001963786.1. XM_001963750.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0125773; FBpp0124265; FBgn0098078.
    GeneIDi6503762.
    KEGGidan:Dana_GF21073.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902622 Genomic DNA. Translation: EDV34235.1 .
    RefSeqi XP_001963786.1. XM_001963750.1.

    3D structure databases

    ProteinModelPortali B3MR30.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7217.FBpp0124265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0125773 ; FBpp0124265 ; FBgn0098078 .
    GeneIDi 6503762.
    KEGGi dan:Dana_GF21073.

    Organism-specific databases

    FlyBasei FBgn0098078. Dana\GF21073.

    Phylogenomic databases

    eggNOGi NOG71348.
    InParanoidi B3MR30.
    KOi K15637.
    OrthoDBi EOG7966H1.
    PhylomeDBi B3MR30.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14024-0371.13Imported.

    Entry informationi

    Entry nameiPGAM5_DROAN
    AccessioniPrimary (citable) accession number: B3MR30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3