Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B3MQV3 (UBE2S_DROAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene names
ORF Names:GF21161
OrganismDrosophila ananassae (Fruit fly) [Complete proteome]
Taxonomic identifier7217 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Ubiquitin-conjugating enzyme E2 S
PRO_0000390437

Sites

Active site981Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
B3MQV3 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 362C5F96410DED4E

FASTA20923,384
        10         20         30         40         50         60 
MSSQYSNVEN LSPQTIRQVM RELQEMETTP PEGIKVLINE SDVTDIQALI DGPAGTPYAA 

        70         80         90        100        110        120 
GIFRVKLTLN KDFPQTPPKA YFLTKIFHPN VAANGEICVN TLKKDWKPDL GIKHILLTIK 

       130        140        150        160        170        180 
CLLIVPNPES ALNEEAGKML LERYDDYSQR ARMMTEIHAQ PAKCAAGAAG DSKDDDGPST 

       190        200 
KKHAGLDKKL QDKKKEKLLK EKKRMLKRL 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14024-0371.13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH902622 Genomic DNA. Translation: EDV34158.1.
RefSeqXP_001963709.1. XM_001963673.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7217.FBpp0124353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0125861; FBpp0124353; FBgn0098164.
GeneID6503846.
KEGGdan:Dana_GF21161.

Organism-specific databases

FlyBaseFBgn0098164. Dana\GF21161.

Phylogenomic databases

eggNOGCOG5078.
InParanoidB3MQV3.
KOK10583.
OrthoDBEOG73JKXD.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2S_DROAN
AccessionPrimary (citable) accession number: B3MQV3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: September 2, 2008
Last modified: March 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase