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B3MKG0 (B3MKG0_DROAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADPH--cytochrome P450 reductase PIRNR PIRNR000208
EC=1.6.2.4 PIRNR PIRNR000208
Gene names
Name:GF14516 FlyBase FBgn0091543
Synonyms:Dana\GF14516 EMBL EDV31513.1
ORF Names:Dana_GF14516 EMBL EDV31513.1
OrganismDrosophila ananassae (Fruit fly) [Complete proteome]
Taxonomic identifier7217 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length678 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is required for electron transfer from NADP to cytochrome P450 By similarity. PIRNR PIRNR000208

Catalytic activity

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. PIRNR PIRNR000208

Subcellular location

Endoplasmic reticulum membrane By similarity PIRNR PIRNR000208.

Sequence similarities

In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. PIRNR PIRNR000208

Sequences

Sequence LengthMass (Da)Tools
B3MKG0 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 1BA5DCABCA3C8CFF

FASTA67876,417
        10         20         30         40         50         60 
MASEQIIEEA AEAVAGGNEP FLGLLDIALL AVLIGGAAFY FLRSRKKEEE PVRSYSIQPT 

        70         80         90        100        110        120 
TVSTTTATDN SFIKKLKASG RSLVVFYGSQ TGTGEEFAGR LAKEGIRYRL KGMVADPEEC 

       130        140        150        160        170        180 
DMEELLQLKD IDNSLAVFCL ATYGEGDPTD NAMEFYEWIT NGDVDLTGLN YAVFGLGNKT 

       190        200        210        220        230        240 
YEHYNKVAIY VDKRLEELGA NRVFELGLGD DDANIEDDFI TWKDRFWPAV CDHFGIEGGG 

       250        260        270        280        290        300 
EEVLIRQYRL LEQPDVQPDR IYTGEIARLH SVQNQRPPFD AKNPFLAPIK VNRELHKGGG 

       310        320        330        340        350        360 
RSCMHIELSI EGSKMRYDAG DHVAMYPIND KGLVEKLGQL CNADLDTIFS LINTDTDSSK 

       370        380        390        400        410        420 
KHPFPCPTTY RTALTHYLEI TAIPRTHILK ELAEYCTDEK EKELLRSMAS ISPEGKEKYQ 

       430        440        450        460        470        480 
SWIQDACRNI VHILEDIKSC RPPIDHVCEL LPRLQPRYYS ISSSGKLHPT DVHVTAVLVE 

       490        500        510        520        530        540 
YKTPTGRVNK GVATTYLKNK QPKDGEEVKV PVFIRKSQFR LPTKPETPII MVGPGTGLAP 

       550        560        570        580        590        600 
FRGFIQERQH LRDEGKTVGE SILYFGCRKR SEDYIYESEL EEWVKKGTLN LKAAFSRDQA 

       610        620        630        640        650        660 
SKVYVQHLLE QDADLIWNVI GENKGHFYIC GDAKNMAVDV RNILVKILST KGNMSEADAV 

       670 
QYIKKMEAQK RYSADVWS

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14024-0371.13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH902620 Genomic DNA. Translation: EDV31513.1.
RefSeqXP_001962292.1. XM_001962256.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING7217.FBpp0117708.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0119216; FBpp0117708; FBgn0091543.
GeneID6497339.
KEGGdan:Dana_GF14516.

Organism-specific databases

FlyBaseFBgn0091543. Dana\GF14516.

Phylogenomic databases

eggNOGCOG0369.
InParanoidB3MKG0.
KOK00327.
OrthoDBEOG4CC2G8.

Family and domain databases

Gene3D1.20.990.10. 1 hit.
InterProIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFPIRSF000208. P450R. 1 hit.
PRINTSPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMSSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3MKG0_DROAN
AccessionPrimary (citable) accession number: B3MKG0
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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