Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291NucleophileBy similarity
Active sitei211 – 2111Proton donorBy similarity
Sitei226 – 2261Important for enzyme activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:GF12763
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0089797. Dana\GF12763.

Subcellular locationi

  • Nucleus By similarity

  • Note: Localizes to PcG response elements (PREs).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395826Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0115955.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG249036.
InParanoidiB3MIV9.
KOiK08588.
OrthoDBiEOG7GN2M2.
PhylomeDBiB3MIV9.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B3MIV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMTGGGAGP QAGPNSSCNI PNSSLLATAP VAATMPIAQL ADGWLELESD
60 70 80 90 100
PGLFTLLLED FGCHDVQVEE VYDLQKPIES PYGFIFLFRW IEERRARRKI
110 120 130 140 150
VETTAEIFVK DEEAISSIFF AQQVVPNSCA THALLSVLLN CNENNLQLGD
160 170 180 190 200
TLSRLKAHTK GMSPENKGLA IGNTPELACA HNSHAMPQAR RRLERTGAGV
210 220 230 240 250
SSCRFTGEAF HFVSFVPING QLFELDGLKP YPMNHGGWED HEDWTDKFRR
260 270 280 290 300
VMTERLGIAT GEQDIRFNLM AVVPDRRIAI THKLKMLRTN QAIVSGTLQK
310 320 330 340 350
LLKADEQGEG GNGDPQRPDT PSTLLEPSAF TARDLQSLLK NLDTEIAINE
360 370 380 390 400
QHLADENDRR HKFKVDASRR THNYDKFICT FLSMLAHQGV LGELVSQHLL
410 420 430 440 450
PSKKISGQSA ANRLNKQSNA TANAGATAAG AAGAAPKSQQ QQAAAAKNGK
460 470
SPSKTPGRRR KGRNKCKKRK
Length:470
Mass (Da):51,537
Last modified:September 2, 2008 - v1
Checksum:i001BABA110687CE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902619 Genomic DNA. Translation: EDV36019.1.
RefSeqiXP_001959197.1. XM_001959161.1.

Genome annotation databases

EnsemblMetazoaiFBtr0117463; FBpp0115955; FBgn0089797.
GeneIDi6495610.
KEGGidan:Dana_GF12763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902619 Genomic DNA. Translation: EDV36019.1.
RefSeqiXP_001959197.1. XM_001959161.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7217.FBpp0115955.

Protein family/group databases

MEROPSiC12.A09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0117463; FBpp0115955; FBgn0089797.
GeneIDi6495610.
KEGGidan:Dana_GF12763.

Organism-specific databases

FlyBaseiFBgn0089797. Dana\GF12763.

Phylogenomic databases

eggNOGiNOG249036.
InParanoidiB3MIV9.
KOiK08588.
OrthoDBiEOG7GN2M2.
PhylomeDBiB3MIV9.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiCALYP_DROAN
AccessioniPrimary (citable) accession number: B3MIV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 2, 2008
Last modified: March 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.