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B3MIV9

- CALYP_DROAN

UniProt

B3MIV9 - CALYP_DROAN

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Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291NucleophileBy similarity
Active sitei211 – 2111Proton donorBy similarity
Sitei226 – 2261Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:GF12763
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0089797. Dana\GF12763.

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs).By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: UniProtKB
  2. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395826Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0115955.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG249036.
InParanoidiB3MIV9.
KOiK08588.
OrthoDBiEOG7GN2M2.
PhylomeDBiB3MIV9.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B3MIV9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNMTGGGAGP QAGPNSSCNI PNSSLLATAP VAATMPIAQL ADGWLELESD
60 70 80 90 100
PGLFTLLLED FGCHDVQVEE VYDLQKPIES PYGFIFLFRW IEERRARRKI
110 120 130 140 150
VETTAEIFVK DEEAISSIFF AQQVVPNSCA THALLSVLLN CNENNLQLGD
160 170 180 190 200
TLSRLKAHTK GMSPENKGLA IGNTPELACA HNSHAMPQAR RRLERTGAGV
210 220 230 240 250
SSCRFTGEAF HFVSFVPING QLFELDGLKP YPMNHGGWED HEDWTDKFRR
260 270 280 290 300
VMTERLGIAT GEQDIRFNLM AVVPDRRIAI THKLKMLRTN QAIVSGTLQK
310 320 330 340 350
LLKADEQGEG GNGDPQRPDT PSTLLEPSAF TARDLQSLLK NLDTEIAINE
360 370 380 390 400
QHLADENDRR HKFKVDASRR THNYDKFICT FLSMLAHQGV LGELVSQHLL
410 420 430 440 450
PSKKISGQSA ANRLNKQSNA TANAGATAAG AAGAAPKSQQ QQAAAAKNGK
460 470
SPSKTPGRRR KGRNKCKKRK
Length:470
Mass (Da):51,537
Last modified:September 2, 2008 - v1
Checksum:i001BABA110687CE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902619 Genomic DNA. Translation: EDV36019.1.
RefSeqiXP_001959197.1. XM_001959161.1.

Genome annotation databases

EnsemblMetazoaiFBtr0117463; FBpp0115955; FBgn0089797.
GeneIDi6495610.
KEGGidan:Dana_GF12763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902619 Genomic DNA. Translation: EDV36019.1 .
RefSeqi XP_001959197.1. XM_001959161.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0115955.

Protein family/group databases

MEROPSi C12.A09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0117463 ; FBpp0115955 ; FBgn0089797 .
GeneIDi 6495610.
KEGGi dan:Dana_GF12763.

Organism-specific databases

FlyBasei FBgn0089797. Dana\GF12763.

Phylogenomic databases

eggNOGi NOG249036.
InParanoidi B3MIV9.
KOi K08588.
OrthoDBi EOG7GN2M2.
PhylomeDBi B3MIV9.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiCALYP_DROAN
AccessioniPrimary (citable) accession number: B3MIV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3