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B3M3M6 (UBP36_DROAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GF23992
OrganismDrosophila ananassae (Fruit fly) [Complete proteome]
Taxonomic identifier7217 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1091 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10911091Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378495

Regions

Domain176 – 484309USP

Sites

Active site1851Nucleophile By similarity
Active site4431Proton acceptor By similarity

Amino acid modifications

Modified residue5181Phosphoserine By similarity
Modified residue5221Phosphoserine By similarity
Modified residue6591Phosphothreonine By similarity
Modified residue6631Phosphothreonine By similarity
Modified residue6731Phosphoserine By similarity
Modified residue6751Phosphoserine By similarity
Modified residue7491Phosphoserine By similarity
Modified residue7831Phosphoserine By similarity
Modified residue7861Phosphothreonine By similarity
Modified residue7891Phosphoserine By similarity
Modified residue8291Phosphothreonine By similarity
Modified residue8471Phosphoserine By similarity
Modified residue8501Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
B3M3M6 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: E146651907DF1A24

FASTA1,091119,512
        10         20         30         40         50         60 
MPVSVAVCET TNVVNAALRE SLGVGIGSGG ASSDDKSAGE DTNSLQNHIV ANAKRILMTK 

        70         80         90        100        110        120 
IEYEEVPNYQ EAVLENLKSK YIVIKPTNPT NGCNLNGNTA NTFGNKNNAG KIVGANGHDN 

       130        140        150        160        170        180 
NGRKLSDHPN QNHNHANPNG HHANPNELPK PKRVLYPREN IRIGWKQSER KWQVGSGMIN 

       190        200        210        220        230        240 
AGNTCYLNST LQALFHIPAL ANWLVSEQAH MENCNVSESG SFCIICAMAK TLQATQTTQS 

       250        260        270        280        290        300 
AVRPFLIYTK LKQICKHMIV GRQEDAHEFL RFLVEAMERA YLMRFRNYKE LDQLVKETTP 

       310        320        330        340        350        360 
LGQIFGGYLR SEVRCLSCNH VSITFQHFQD LLLDIRKSDS LEEAFEGYFS REKLEDFGYK 

       370        380        390        400        410        420 
CEGCKKKVSA TKQFRLERAP ITLCIQLKRF SMMGNKLTKQ ITFKPRIDLS KFAARSPAAS 

       430        440        450        460        470        480 
VQPLIYRLVS MVTHLGVSQH CGHYTAIGST EAGSYYNFDD SYVRPIAIQS VCNTNAYIMF 

       490        500        510        520        530        540 
YELDPLQTSS PAAARANGLR LTNGHGPVPV AVPATVSSPL PSPAKFIGPQ LPPGGINGYS 

       550        560        570        580        590        600 
NGHGPKTTIQ FKPQHQPSHQ QNGVQQSAKS PLLSTHVKVE AAAGAAALAA SAAPTANGNK 

       610        620        630        640        650        660 
SSSNHSNHKS VNQQHYLPIS SEDEDSEDEV KARPTVQLPS MPKMDDCMDS GKPKSPVKTP 

       670        680        690        700        710        720 
VKTPLKSLVP YESASEEEEV VPLPNPNARK RSSDSSDSEH EPTTSSVQLN GHSKTNGSLS 

       730        740        750        760        770        780 
NGSSKSTDAI DEIFKSLKGY QAKKKSADSE DDDDDEDEPN NQLTNGWHPQ KQSQSQSRSG 

       790        800        810        820        830        840 
PPSPKTPPSP AVIKSKTGIW KVTRDDGDDD EDDDDDDDEV VEEARAVRTP VKNHRNPFAS 

       850        860        870        880        890        900 
SKTATDSPTT PGAKRQKLLN GSAIKTQQQP RAGNGYQSEA TANGGTVNEL LKQSHRGYSS 

       910        920        930        940        950        960 
SVLSWNGKPA ELEKEPFVLV CAKRIAGHGS LDGSGSGSNT DIIDTEIPAA AVNFPSGSCS 

       970        980        990       1000       1010       1020 
FSLLADARDQ RQRDLADDEE NEMDRGRQRK VKSGSAKISN STPGYNPFME FENQKRWHKN 

      1030       1040       1050       1060       1070       1080 
GGGGGFPRFY QNQNFRQGFQ QRNKFKFNRF GGPGSAKFQQ QRALQRHLAA GGGFTRRQPT 

      1090 
HSAQQQQQQQ S 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14024-0371.13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH902618 Genomic DNA. Translation: EDV40319.1.
RefSeqXP_001957513.1. XM_001957477.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7217.FBpp0127184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0128692; FBpp0127184; FBgn0100986.
GeneID6506628.
KEGGdan:Dana_GF23992.

Organism-specific databases

FlyBaseFBgn0100986. Dana\GF23992.

Phylogenomic databases

eggNOGCOG5533.
InParanoidB3M3M6.
KOK11855.
OrthoDBEOG7XDBF6.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROAN
AccessionPrimary (citable) accession number: B3M3M6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 2, 2008
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase