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B3M3M6

- UBP36_DROAN

UniProt

B3M3M6 - UBP36_DROAN

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei185 – 1851NucleophilePROSITE-ProRule annotation
    Active sitei443 – 4431Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GF23992
    OrganismiDrosophila ananassae (Fruit fly)
    Taxonomic identifieri7217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007801: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0100986. Dana\GF23992.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10911091Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378495Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei518 – 5181PhosphoserineBy similarity
    Modified residuei522 – 5221PhosphoserineBy similarity
    Modified residuei659 – 6591PhosphothreonineBy similarity
    Modified residuei663 – 6631PhosphothreonineBy similarity
    Modified residuei673 – 6731PhosphoserineBy similarity
    Modified residuei675 – 6751PhosphoserineBy similarity
    Modified residuei749 – 7491PhosphoserineBy similarity
    Modified residuei783 – 7831PhosphoserineBy similarity
    Modified residuei786 – 7861PhosphothreonineBy similarity
    Modified residuei789 – 7891PhosphoserineBy similarity
    Modified residuei829 – 8291PhosphothreonineBy similarity
    Modified residuei847 – 8471PhosphoserineBy similarity
    Modified residuei850 – 8501PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Protein-protein interaction databases

    STRINGi7217.FBpp0127184.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini176 – 484309USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    InParanoidiB3M3M6.
    KOiK11855.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB3M3M6.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3M3M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSVAVCET TNVVNAALRE SLGVGIGSGG ASSDDKSAGE DTNSLQNHIV     50
    ANAKRILMTK IEYEEVPNYQ EAVLENLKSK YIVIKPTNPT NGCNLNGNTA 100
    NTFGNKNNAG KIVGANGHDN NGRKLSDHPN QNHNHANPNG HHANPNELPK 150
    PKRVLYPREN IRIGWKQSER KWQVGSGMIN AGNTCYLNST LQALFHIPAL 200
    ANWLVSEQAH MENCNVSESG SFCIICAMAK TLQATQTTQS AVRPFLIYTK 250
    LKQICKHMIV GRQEDAHEFL RFLVEAMERA YLMRFRNYKE LDQLVKETTP 300
    LGQIFGGYLR SEVRCLSCNH VSITFQHFQD LLLDIRKSDS LEEAFEGYFS 350
    REKLEDFGYK CEGCKKKVSA TKQFRLERAP ITLCIQLKRF SMMGNKLTKQ 400
    ITFKPRIDLS KFAARSPAAS VQPLIYRLVS MVTHLGVSQH CGHYTAIGST 450
    EAGSYYNFDD SYVRPIAIQS VCNTNAYIMF YELDPLQTSS PAAARANGLR 500
    LTNGHGPVPV AVPATVSSPL PSPAKFIGPQ LPPGGINGYS NGHGPKTTIQ 550
    FKPQHQPSHQ QNGVQQSAKS PLLSTHVKVE AAAGAAALAA SAAPTANGNK 600
    SSSNHSNHKS VNQQHYLPIS SEDEDSEDEV KARPTVQLPS MPKMDDCMDS 650
    GKPKSPVKTP VKTPLKSLVP YESASEEEEV VPLPNPNARK RSSDSSDSEH 700
    EPTTSSVQLN GHSKTNGSLS NGSSKSTDAI DEIFKSLKGY QAKKKSADSE 750
    DDDDDEDEPN NQLTNGWHPQ KQSQSQSRSG PPSPKTPPSP AVIKSKTGIW 800
    KVTRDDGDDD EDDDDDDDEV VEEARAVRTP VKNHRNPFAS SKTATDSPTT 850
    PGAKRQKLLN GSAIKTQQQP RAGNGYQSEA TANGGTVNEL LKQSHRGYSS 900
    SVLSWNGKPA ELEKEPFVLV CAKRIAGHGS LDGSGSGSNT DIIDTEIPAA 950
    AVNFPSGSCS FSLLADARDQ RQRDLADDEE NEMDRGRQRK VKSGSAKISN 1000
    STPGYNPFME FENQKRWHKN GGGGGFPRFY QNQNFRQGFQ QRNKFKFNRF 1050
    GGPGSAKFQQ QRALQRHLAA GGGFTRRQPT HSAQQQQQQQ S 1091
    Length:1,091
    Mass (Da):119,512
    Last modified:September 2, 2008 - v1
    Checksum:iE146651907DF1A24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902618 Genomic DNA. Translation: EDV40319.1.
    RefSeqiXP_001957513.1. XM_001957477.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0128692; FBpp0127184; FBgn0100986.
    GeneIDi6506628.
    KEGGidan:Dana_GF23992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902618 Genomic DNA. Translation: EDV40319.1 .
    RefSeqi XP_001957513.1. XM_001957477.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7217.FBpp0127184.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0128692 ; FBpp0127184 ; FBgn0100986 .
    GeneIDi 6506628.
    KEGGi dan:Dana_GF23992.

    Organism-specific databases

    FlyBasei FBgn0100986. Dana\GF23992.

    Phylogenomic databases

    eggNOGi COG5533.
    InParanoidi B3M3M6.
    KOi K11855.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B3M3M6.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14024-0371.13.

    Entry informationi

    Entry nameiUBP36_DROAN
    AccessioniPrimary (citable) accession number: B3M3M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3