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B3M3M6

- UBP36_DROAN

UniProt

B3M3M6 - UBP36_DROAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851NucleophilePROSITE-ProRule annotation
Active sitei443 – 4431Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.097.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GF23992
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0100986. Dana\GF23992.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10911091Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei518 – 5181PhosphoserineBy similarity
Modified residuei522 – 5221PhosphoserineBy similarity
Modified residuei659 – 6591PhosphothreonineBy similarity
Modified residuei663 – 6631PhosphothreonineBy similarity
Modified residuei673 – 6731PhosphoserineBy similarity
Modified residuei675 – 6751PhosphoserineBy similarity
Modified residuei749 – 7491PhosphoserineBy similarity
Modified residuei783 – 7831PhosphoserineBy similarity
Modified residuei786 – 7861PhosphothreonineBy similarity
Modified residuei789 – 7891PhosphoserineBy similarity
Modified residuei829 – 8291PhosphothreonineBy similarity
Modified residuei847 – 8471PhosphoserineBy similarity
Modified residuei850 – 8501PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0127184.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 484309USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiB3M3M6.
KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB3M3M6.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3M3M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSVAVCET TNVVNAALRE SLGVGIGSGG ASSDDKSAGE DTNSLQNHIV
60 70 80 90 100
ANAKRILMTK IEYEEVPNYQ EAVLENLKSK YIVIKPTNPT NGCNLNGNTA
110 120 130 140 150
NTFGNKNNAG KIVGANGHDN NGRKLSDHPN QNHNHANPNG HHANPNELPK
160 170 180 190 200
PKRVLYPREN IRIGWKQSER KWQVGSGMIN AGNTCYLNST LQALFHIPAL
210 220 230 240 250
ANWLVSEQAH MENCNVSESG SFCIICAMAK TLQATQTTQS AVRPFLIYTK
260 270 280 290 300
LKQICKHMIV GRQEDAHEFL RFLVEAMERA YLMRFRNYKE LDQLVKETTP
310 320 330 340 350
LGQIFGGYLR SEVRCLSCNH VSITFQHFQD LLLDIRKSDS LEEAFEGYFS
360 370 380 390 400
REKLEDFGYK CEGCKKKVSA TKQFRLERAP ITLCIQLKRF SMMGNKLTKQ
410 420 430 440 450
ITFKPRIDLS KFAARSPAAS VQPLIYRLVS MVTHLGVSQH CGHYTAIGST
460 470 480 490 500
EAGSYYNFDD SYVRPIAIQS VCNTNAYIMF YELDPLQTSS PAAARANGLR
510 520 530 540 550
LTNGHGPVPV AVPATVSSPL PSPAKFIGPQ LPPGGINGYS NGHGPKTTIQ
560 570 580 590 600
FKPQHQPSHQ QNGVQQSAKS PLLSTHVKVE AAAGAAALAA SAAPTANGNK
610 620 630 640 650
SSSNHSNHKS VNQQHYLPIS SEDEDSEDEV KARPTVQLPS MPKMDDCMDS
660 670 680 690 700
GKPKSPVKTP VKTPLKSLVP YESASEEEEV VPLPNPNARK RSSDSSDSEH
710 720 730 740 750
EPTTSSVQLN GHSKTNGSLS NGSSKSTDAI DEIFKSLKGY QAKKKSADSE
760 770 780 790 800
DDDDDEDEPN NQLTNGWHPQ KQSQSQSRSG PPSPKTPPSP AVIKSKTGIW
810 820 830 840 850
KVTRDDGDDD EDDDDDDDEV VEEARAVRTP VKNHRNPFAS SKTATDSPTT
860 870 880 890 900
PGAKRQKLLN GSAIKTQQQP RAGNGYQSEA TANGGTVNEL LKQSHRGYSS
910 920 930 940 950
SVLSWNGKPA ELEKEPFVLV CAKRIAGHGS LDGSGSGSNT DIIDTEIPAA
960 970 980 990 1000
AVNFPSGSCS FSLLADARDQ RQRDLADDEE NEMDRGRQRK VKSGSAKISN
1010 1020 1030 1040 1050
STPGYNPFME FENQKRWHKN GGGGGFPRFY QNQNFRQGFQ QRNKFKFNRF
1060 1070 1080 1090
GGPGSAKFQQ QRALQRHLAA GGGFTRRQPT HSAQQQQQQQ S
Length:1,091
Mass (Da):119,512
Last modified:September 2, 2008 - v1
Checksum:iE146651907DF1A24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902618 Genomic DNA. Translation: EDV40319.1.
RefSeqiXP_001957513.1. XM_001957477.1.

Genome annotation databases

EnsemblMetazoaiFBtr0128692; FBpp0127184; FBgn0100986.
GeneIDi6506628.
KEGGidan:Dana_GF23992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902618 Genomic DNA. Translation: EDV40319.1 .
RefSeqi XP_001957513.1. XM_001957477.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0127184.

Protein family/group databases

MEROPSi C19.097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0128692 ; FBpp0127184 ; FBgn0100986 .
GeneIDi 6506628.
KEGGi dan:Dana_GF23992.

Organism-specific databases

FlyBasei FBgn0100986. Dana\GF23992.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi B3M3M6.
KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B3M3M6.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiUBP36_DROAN
AccessioniPrimary (citable) accession number: B3M3M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3