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B3M0V2

- B3M0V2_DROAN

UniProt

B3M0V2 - B3M0V2_DROAN

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dana\GF18361

Organism
Drosophila ananassae (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:Dana\GF18361Imported
ORF Names:Dana_GF18361Imported, GF18361Imported
OrganismiDrosophila ananassae (Fruit fly)Imported
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0095379. Dana\GF18361.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0121553.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiB3M0V2.
KOiK11427.
OrthoDBiEOG7W6WJV.
PhylomeDBiB3M0V2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3M0V2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPQVKDLV LRSPAGSSDV ITFAWPLQIG HGQDKHDNGI DIIDTIKFVC
60 70 80 90 100
DELPSMSSAF EETNLNQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP
110 120 130 140 150
AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV
160 170 180 190 200
QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY
210 220 230 240 250
AERMDVFFRQ YMGWFGKRYC EYKLIKGDFL VDEHREKITS STLVFVNNFA
260 270 280 290 300
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS
310 320 330 340 350
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHEGVGTVR
360 370 380 390 400
TTRDRAKREA NVGQHHHHNH HANNTNHANN HNNHHRERER EQSNGAASAA
410 420 430 440 450
QLQRQKSQSP ANVSGSGGLA GVGVQPATGA SAAANSKTRQ QLQQQQQQQQ
460 470 480 490 500
QQRSLDMESS TESDGEATNG NGGNTTTTTN ATSASNGPMT RKVWSDWCSS
510 520 530 540 550
KGKSSQSDDE ENNNSNSNGG SNTGAGNGNG NGGGGVVGRQ ARAATQKKRK
560 570 580 590 600
KLTRKAAIAS KSAAAAQREA EAAAAAVAAA TASKDSSSKE DQPRAAIGGP
610 620 630 640 650
GRKGRMKKGA RGRKSLKIVG LEALHKQTVL STSLDAMTKK LPAAPGTVDQ
660 670 680 690 700
QLTALLTDNM AHTELDIPTA PQDTPYALQI LLDVFRSQYM AMIDQMKSSA
710 720 730 740 750
FVPQVQKQLA QEQERMARLK NRASQLDKQI KVLIDDSVAL LKVRMNELGI
760 770 780 790 800
NVNSPNDLIA QAKEIVGRHK DLQHTVSRMR NEVTYYEGEQ KHLLSKQLKN
810 820 830 840 850
LSEYQKLCTG ANGKVKLEMP PELSETTAQE LVLKEIANTL SQRKKLYAQV
860 870 880 890 900
STIEQETTVL QKTAEERSTA AVLLAQGTNM SLATGSPSTA SSGSSTPSTA
910 920 930 940 950
LAGSTPVSVP NSKLNSVKNS RRSREHRGRS QEWPEVPEVG KIQESNPEVL
960 970 980 990 1000
AQKIVETCRQ IEAGKFQGAA APTYQVNGKN KAIPEAGVPP NPVAVAPVSI
1010 1020 1030 1040 1050
KSSPGHHYKD STLMPAPKQQ SQQQVTASLL PKCELGGLSA SRIKQESPKV
1060 1070 1080 1090 1100
ANFEDRLKSI ITTALNEDQE HRSKAVEPSP SPSPLHSPAP KRSKQQLQQP
1110 1120 1130 1140 1150
GSMNPGQQQL PNSLHNIITV STQGLMHLNA NTTISPITPP LPGPGAGAAA
1160 1170 1180 1190 1200
STAPPPPANL PYGAYGGKAT VSGKYQAAKE PKYSPVRQAP PPPPPPPSHM
1210 1220 1230 1240 1250
AALYAAGAGQ QTGSTDLSYQ RRRSSVSASS YEHFMAQQQQ QQQQHALMLA
1260 1270 1280 1290 1300
AAAHAAQRQQ MRAEEQQQQH QQQQNQVQQH HQHQQHRLQQ QQQQQQQQHL
1310 1320 1330 1340 1350
QHHHHPNEFK APPSENLLQR SSSREQLIVE PQQQPLELLP RASSANSDYG
1360 1370 1380 1390 1400
GYRIRPPSRP SSNSSQPDYT QVSPAKMALR RHLSQEKLSQ HGTPQATPPL
1410 1420 1430 1440 1450
PGSGAPTSGK TIGDLVNGEI ERTLEISHQS IINAAVNMST GGAHFMERAF
1460 1470 1480 1490 1500
LNERSNERLL INLNAQRPER VHVRPMSEES QEPHPTSYAQ ERGSVGSAGG
1510 1520 1530 1540 1550
NSNLATLAHV AYVQKAQGAG AARAGATAPP AAQHHAATAR TGRDYQPVAL
1560 1570 1580 1590 1600
PRAELKGSIE AYFHEEQQQQ QKQSKGAGSG SSGAAAMRGS RLNGANPPLE
1610 1620 1630 1640 1650
GLAASLQDHV RARKYKEETE ERQRRAAAAA SSSSSASNSA LELSNHYGHQ
1660 1670 1680 1690 1700
APPAHNYHHH HHAANLNGTP HKVELGVKRS SPLAPHQQPP RPSKLAHYDA
1710 1720 1730 1740 1750
PPNSGQSHHA HIYANGQVLQ PPPAHDATTP SPTPSSSSSS CGRRSGSNSG
1760 1770 1780 1790 1800
KMLVEPPLLM SPEINSLMGD ERPLQLSSHQ SQTQMLQQHQ QAHLQPLRVP
1810 1820 1830 1840 1850
HLGHGHGHGH SHSTTPTLGE RRNANAADDV NDLATQRTIT NYDPRRRLRT
1860 1870 1880 1890
TLSGPTKLAQ SADHAHAHSS QNLNGYVLAD SSSSCPTIPN TTQ
Length:1,893
Mass (Da):205,332
Last modified:September 2, 2008 - v1
Checksum:i51A8D712C10F23E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV43181.1.
RefSeqiXP_001954620.1. XM_001954584.1.

Genome annotation databases

EnsemblMetazoaiFBtr0123061; FBpp0121553; FBgn0095379.
GeneIDi6501137.
KEGGidan:Dana_GF18361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV43181.1 .
RefSeqi XP_001954620.1. XM_001954584.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0121553.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0123061 ; FBpp0121553 ; FBgn0095379 .
GeneIDi 6501137.
KEGGi dan:Dana_GF18361.

Organism-specific databases

FlyBasei FBgn0095379. Dana\GF18361.

Phylogenomic databases

eggNOGi NOG294902.
InParanoidi B3M0V2.
KOi K11427.
OrthoDBi EOG7W6WJV.
PhylomeDBi B3M0V2.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13Imported.

Entry informationi

Entry nameiB3M0V2_DROAN
AccessioniPrimary (citable) accession number: B3M0V2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3