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B3M0V2

- B3M0V2_DROAN

UniProt

B3M0V2 - B3M0V2_DROAN

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dana\GF18361

Organism
Drosophila ananassae (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    Name:Dana\GF18361Imported
    ORF Names:Dana_GF18361Imported, GF18361Imported
    OrganismiDrosophila ananassae (Fruit fly)Imported
    Taxonomic identifieri7217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007801: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0095379. Dana\GF18361.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi7217.FBpp0121553.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    InParanoidiB3M0V2.
    KOiK11427.
    OrthoDBiEOG7W6WJV.
    PhylomeDBiB3M0V2.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3M0V2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPQVKDLV LRSPAGSSDV ITFAWPLQIG HGQDKHDNGI DIIDTIKFVC     50
    DELPSMSSAF EETNLNQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP 100
    AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV 150
    QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY 200
    AERMDVFFRQ YMGWFGKRYC EYKLIKGDFL VDEHREKITS STLVFVNNFA 250
    FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 300
    EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHEGVGTVR 350
    TTRDRAKREA NVGQHHHHNH HANNTNHANN HNNHHRERER EQSNGAASAA 400
    QLQRQKSQSP ANVSGSGGLA GVGVQPATGA SAAANSKTRQ QLQQQQQQQQ 450
    QQRSLDMESS TESDGEATNG NGGNTTTTTN ATSASNGPMT RKVWSDWCSS 500
    KGKSSQSDDE ENNNSNSNGG SNTGAGNGNG NGGGGVVGRQ ARAATQKKRK 550
    KLTRKAAIAS KSAAAAQREA EAAAAAVAAA TASKDSSSKE DQPRAAIGGP 600
    GRKGRMKKGA RGRKSLKIVG LEALHKQTVL STSLDAMTKK LPAAPGTVDQ 650
    QLTALLTDNM AHTELDIPTA PQDTPYALQI LLDVFRSQYM AMIDQMKSSA 700
    FVPQVQKQLA QEQERMARLK NRASQLDKQI KVLIDDSVAL LKVRMNELGI 750
    NVNSPNDLIA QAKEIVGRHK DLQHTVSRMR NEVTYYEGEQ KHLLSKQLKN 800
    LSEYQKLCTG ANGKVKLEMP PELSETTAQE LVLKEIANTL SQRKKLYAQV 850
    STIEQETTVL QKTAEERSTA AVLLAQGTNM SLATGSPSTA SSGSSTPSTA 900
    LAGSTPVSVP NSKLNSVKNS RRSREHRGRS QEWPEVPEVG KIQESNPEVL 950
    AQKIVETCRQ IEAGKFQGAA APTYQVNGKN KAIPEAGVPP NPVAVAPVSI 1000
    KSSPGHHYKD STLMPAPKQQ SQQQVTASLL PKCELGGLSA SRIKQESPKV 1050
    ANFEDRLKSI ITTALNEDQE HRSKAVEPSP SPSPLHSPAP KRSKQQLQQP 1100
    GSMNPGQQQL PNSLHNIITV STQGLMHLNA NTTISPITPP LPGPGAGAAA 1150
    STAPPPPANL PYGAYGGKAT VSGKYQAAKE PKYSPVRQAP PPPPPPPSHM 1200
    AALYAAGAGQ QTGSTDLSYQ RRRSSVSASS YEHFMAQQQQ QQQQHALMLA 1250
    AAAHAAQRQQ MRAEEQQQQH QQQQNQVQQH HQHQQHRLQQ QQQQQQQQHL 1300
    QHHHHPNEFK APPSENLLQR SSSREQLIVE PQQQPLELLP RASSANSDYG 1350
    GYRIRPPSRP SSNSSQPDYT QVSPAKMALR RHLSQEKLSQ HGTPQATPPL 1400
    PGSGAPTSGK TIGDLVNGEI ERTLEISHQS IINAAVNMST GGAHFMERAF 1450
    LNERSNERLL INLNAQRPER VHVRPMSEES QEPHPTSYAQ ERGSVGSAGG 1500
    NSNLATLAHV AYVQKAQGAG AARAGATAPP AAQHHAATAR TGRDYQPVAL 1550
    PRAELKGSIE AYFHEEQQQQ QKQSKGAGSG SSGAAAMRGS RLNGANPPLE 1600
    GLAASLQDHV RARKYKEETE ERQRRAAAAA SSSSSASNSA LELSNHYGHQ 1650
    APPAHNYHHH HHAANLNGTP HKVELGVKRS SPLAPHQQPP RPSKLAHYDA 1700
    PPNSGQSHHA HIYANGQVLQ PPPAHDATTP SPTPSSSSSS CGRRSGSNSG 1750
    KMLVEPPLLM SPEINSLMGD ERPLQLSSHQ SQTQMLQQHQ QAHLQPLRVP 1800
    HLGHGHGHGH SHSTTPTLGE RRNANAADDV NDLATQRTIT NYDPRRRLRT 1850
    TLSGPTKLAQ SADHAHAHSS QNLNGYVLAD SSSSCPTIPN TTQ 1893
    Length:1,893
    Mass (Da):205,332
    Last modified:September 2, 2008 - v1
    Checksum:i51A8D712C10F23E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902617 Genomic DNA. Translation: EDV43181.1.
    RefSeqiXP_001954620.1. XM_001954584.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0123061; FBpp0121553; FBgn0095379.
    GeneIDi6501137.
    KEGGidan:Dana_GF18361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902617 Genomic DNA. Translation: EDV43181.1 .
    RefSeqi XP_001954620.1. XM_001954584.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7217.FBpp0121553.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0123061 ; FBpp0121553 ; FBgn0095379 .
    GeneIDi 6501137.
    KEGGi dan:Dana_GF18361.

    Organism-specific databases

    FlyBasei FBgn0095379. Dana\GF18361.

    Phylogenomic databases

    eggNOGi NOG294902.
    InParanoidi B3M0V2.
    KOi K11427.
    OrthoDBi EOG7W6WJV.
    PhylomeDBi B3M0V2.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14024-0371.13Imported.

    Entry informationi

    Entry nameiB3M0V2_DROAN
    AccessioniPrimary (citable) accession number: B3M0V2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3