SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B3M0V2

- B3M0V2_DROAN

UniProt

B3M0V2 - B3M0V2_DROAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
Dana\GF18361, Dana_GF18361, GF18361
Organism
Drosophila ananassae (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
Name:Dana\GF18361Imported
ORF Names:Dana_GF18361Imported, GF18361Imported
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0095379. Dana\GF18361.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0121553.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiB3M0V2.
KOiK11427.
OrthoDBiEOG7W6WJV.
PhylomeDBiB3M0V2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3M0V2-1 [UniParc]FASTAAdd to Basket

« Hide

MATPQVKDLV LRSPAGSSDV ITFAWPLQIG HGQDKHDNGI DIIDTIKFVC     50
DELPSMSSAF EETNLNQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP 100
AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV 150
QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY 200
AERMDVFFRQ YMGWFGKRYC EYKLIKGDFL VDEHREKITS STLVFVNNFA 250
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 300
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHEGVGTVR 350
TTRDRAKREA NVGQHHHHNH HANNTNHANN HNNHHRERER EQSNGAASAA 400
QLQRQKSQSP ANVSGSGGLA GVGVQPATGA SAAANSKTRQ QLQQQQQQQQ 450
QQRSLDMESS TESDGEATNG NGGNTTTTTN ATSASNGPMT RKVWSDWCSS 500
KGKSSQSDDE ENNNSNSNGG SNTGAGNGNG NGGGGVVGRQ ARAATQKKRK 550
KLTRKAAIAS KSAAAAQREA EAAAAAVAAA TASKDSSSKE DQPRAAIGGP 600
GRKGRMKKGA RGRKSLKIVG LEALHKQTVL STSLDAMTKK LPAAPGTVDQ 650
QLTALLTDNM AHTELDIPTA PQDTPYALQI LLDVFRSQYM AMIDQMKSSA 700
FVPQVQKQLA QEQERMARLK NRASQLDKQI KVLIDDSVAL LKVRMNELGI 750
NVNSPNDLIA QAKEIVGRHK DLQHTVSRMR NEVTYYEGEQ KHLLSKQLKN 800
LSEYQKLCTG ANGKVKLEMP PELSETTAQE LVLKEIANTL SQRKKLYAQV 850
STIEQETTVL QKTAEERSTA AVLLAQGTNM SLATGSPSTA SSGSSTPSTA 900
LAGSTPVSVP NSKLNSVKNS RRSREHRGRS QEWPEVPEVG KIQESNPEVL 950
AQKIVETCRQ IEAGKFQGAA APTYQVNGKN KAIPEAGVPP NPVAVAPVSI 1000
KSSPGHHYKD STLMPAPKQQ SQQQVTASLL PKCELGGLSA SRIKQESPKV 1050
ANFEDRLKSI ITTALNEDQE HRSKAVEPSP SPSPLHSPAP KRSKQQLQQP 1100
GSMNPGQQQL PNSLHNIITV STQGLMHLNA NTTISPITPP LPGPGAGAAA 1150
STAPPPPANL PYGAYGGKAT VSGKYQAAKE PKYSPVRQAP PPPPPPPSHM 1200
AALYAAGAGQ QTGSTDLSYQ RRRSSVSASS YEHFMAQQQQ QQQQHALMLA 1250
AAAHAAQRQQ MRAEEQQQQH QQQQNQVQQH HQHQQHRLQQ QQQQQQQQHL 1300
QHHHHPNEFK APPSENLLQR SSSREQLIVE PQQQPLELLP RASSANSDYG 1350
GYRIRPPSRP SSNSSQPDYT QVSPAKMALR RHLSQEKLSQ HGTPQATPPL 1400
PGSGAPTSGK TIGDLVNGEI ERTLEISHQS IINAAVNMST GGAHFMERAF 1450
LNERSNERLL INLNAQRPER VHVRPMSEES QEPHPTSYAQ ERGSVGSAGG 1500
NSNLATLAHV AYVQKAQGAG AARAGATAPP AAQHHAATAR TGRDYQPVAL 1550
PRAELKGSIE AYFHEEQQQQ QKQSKGAGSG SSGAAAMRGS RLNGANPPLE 1600
GLAASLQDHV RARKYKEETE ERQRRAAAAA SSSSSASNSA LELSNHYGHQ 1650
APPAHNYHHH HHAANLNGTP HKVELGVKRS SPLAPHQQPP RPSKLAHYDA 1700
PPNSGQSHHA HIYANGQVLQ PPPAHDATTP SPTPSSSSSS CGRRSGSNSG 1750
KMLVEPPLLM SPEINSLMGD ERPLQLSSHQ SQTQMLQQHQ QAHLQPLRVP 1800
HLGHGHGHGH SHSTTPTLGE RRNANAADDV NDLATQRTIT NYDPRRRLRT 1850
TLSGPTKLAQ SADHAHAHSS QNLNGYVLAD SSSSCPTIPN TTQ 1893
Length:1,893
Mass (Da):205,332
Last modified:September 2, 2008 - v1
Checksum:i51A8D712C10F23E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV43181.1.
RefSeqiXP_001954620.1. XM_001954584.1.

Genome annotation databases

EnsemblMetazoaiFBtr0123061; FBpp0121553; FBgn0095379.
GeneIDi6501137.
KEGGidan:Dana_GF18361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV43181.1 .
RefSeqi XP_001954620.1. XM_001954584.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0121553.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0123061 ; FBpp0121553 ; FBgn0095379 .
GeneIDi 6501137.
KEGGi dan:Dana_GF18361.

Organism-specific databases

FlyBasei FBgn0095379. Dana\GF18361.

Phylogenomic databases

eggNOGi NOG294902.
InParanoidi B3M0V2.
KOi K11427.
OrthoDBi EOG7W6WJV.
PhylomeDBi B3M0V2.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiB3M0V2_DROAN
AccessioniPrimary (citable) accession number: B3M0V2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3