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B3M0V2 (B3M0V2_DROAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
Name:Dana\GF18361 EMBL EDV43181.1
ORF Names:Dana_GF18361 EMBL EDV43181.1, GF18361 FlyBase FBgn0095379
OrganismDrosophila ananassae (Fruit fly) [Complete proteome]
Taxonomic identifier7217 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1893 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU271113
   LigandS-adenosyl-L-methionine RuleBase RU271113
   Molecular functionChromatin regulator RuleBase RU271113
Methyltransferase RuleBase RU271113
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B3M0V2 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 51A8D712C10F23E0

FASTA1,893205,332
        10         20         30         40         50         60 
MATPQVKDLV LRSPAGSSDV ITFAWPLQIG HGQDKHDNGI DIIDTIKFVC DELPSMSSAF 

        70         80         90        100        110        120 
EETNLNQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP AERLNKFAHP SLLRHILQLV 

       130        140        150        160        170        180 
YNAAVLDPDK LNQYEPFSPE VYGETSYELV QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA 

       190        200        210        220        230        240 
GSFPLKTCIG IEKADTPARY AERMDVFFRQ YMGWFGKRYC EYKLIKGDFL VDEHREKITS 

       250        260        270        280        290        300 
STLVFVNNFA FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 

       310        320        330        340        350        360 
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHEGVGTVR TTRDRAKREA 

       370        380        390        400        410        420 
NVGQHHHHNH HANNTNHANN HNNHHRERER EQSNGAASAA QLQRQKSQSP ANVSGSGGLA 

       430        440        450        460        470        480 
GVGVQPATGA SAAANSKTRQ QLQQQQQQQQ QQRSLDMESS TESDGEATNG NGGNTTTTTN 

       490        500        510        520        530        540 
ATSASNGPMT RKVWSDWCSS KGKSSQSDDE ENNNSNSNGG SNTGAGNGNG NGGGGVVGRQ 

       550        560        570        580        590        600 
ARAATQKKRK KLTRKAAIAS KSAAAAQREA EAAAAAVAAA TASKDSSSKE DQPRAAIGGP 

       610        620        630        640        650        660 
GRKGRMKKGA RGRKSLKIVG LEALHKQTVL STSLDAMTKK LPAAPGTVDQ QLTALLTDNM 

       670        680        690        700        710        720 
AHTELDIPTA PQDTPYALQI LLDVFRSQYM AMIDQMKSSA FVPQVQKQLA QEQERMARLK 

       730        740        750        760        770        780 
NRASQLDKQI KVLIDDSVAL LKVRMNELGI NVNSPNDLIA QAKEIVGRHK DLQHTVSRMR 

       790        800        810        820        830        840 
NEVTYYEGEQ KHLLSKQLKN LSEYQKLCTG ANGKVKLEMP PELSETTAQE LVLKEIANTL 

       850        860        870        880        890        900 
SQRKKLYAQV STIEQETTVL QKTAEERSTA AVLLAQGTNM SLATGSPSTA SSGSSTPSTA 

       910        920        930        940        950        960 
LAGSTPVSVP NSKLNSVKNS RRSREHRGRS QEWPEVPEVG KIQESNPEVL AQKIVETCRQ 

       970        980        990       1000       1010       1020 
IEAGKFQGAA APTYQVNGKN KAIPEAGVPP NPVAVAPVSI KSSPGHHYKD STLMPAPKQQ 

      1030       1040       1050       1060       1070       1080 
SQQQVTASLL PKCELGGLSA SRIKQESPKV ANFEDRLKSI ITTALNEDQE HRSKAVEPSP 

      1090       1100       1110       1120       1130       1140 
SPSPLHSPAP KRSKQQLQQP GSMNPGQQQL PNSLHNIITV STQGLMHLNA NTTISPITPP 

      1150       1160       1170       1180       1190       1200 
LPGPGAGAAA STAPPPPANL PYGAYGGKAT VSGKYQAAKE PKYSPVRQAP PPPPPPPSHM 

      1210       1220       1230       1240       1250       1260 
AALYAAGAGQ QTGSTDLSYQ RRRSSVSASS YEHFMAQQQQ QQQQHALMLA AAAHAAQRQQ 

      1270       1280       1290       1300       1310       1320 
MRAEEQQQQH QQQQNQVQQH HQHQQHRLQQ QQQQQQQQHL QHHHHPNEFK APPSENLLQR 

      1330       1340       1350       1360       1370       1380 
SSSREQLIVE PQQQPLELLP RASSANSDYG GYRIRPPSRP SSNSSQPDYT QVSPAKMALR 

      1390       1400       1410       1420       1430       1440 
RHLSQEKLSQ HGTPQATPPL PGSGAPTSGK TIGDLVNGEI ERTLEISHQS IINAAVNMST 

      1450       1460       1470       1480       1490       1500 
GGAHFMERAF LNERSNERLL INLNAQRPER VHVRPMSEES QEPHPTSYAQ ERGSVGSAGG 

      1510       1520       1530       1540       1550       1560 
NSNLATLAHV AYVQKAQGAG AARAGATAPP AAQHHAATAR TGRDYQPVAL PRAELKGSIE 

      1570       1580       1590       1600       1610       1620 
AYFHEEQQQQ QKQSKGAGSG SSGAAAMRGS RLNGANPPLE GLAASLQDHV RARKYKEETE 

      1630       1640       1650       1660       1670       1680 
ERQRRAAAAA SSSSSASNSA LELSNHYGHQ APPAHNYHHH HHAANLNGTP HKVELGVKRS 

      1690       1700       1710       1720       1730       1740 
SPLAPHQQPP RPSKLAHYDA PPNSGQSHHA HIYANGQVLQ PPPAHDATTP SPTPSSSSSS 

      1750       1760       1770       1780       1790       1800 
CGRRSGSNSG KMLVEPPLLM SPEINSLMGD ERPLQLSSHQ SQTQMLQQHQ QAHLQPLRVP 

      1810       1820       1830       1840       1850       1860 
HLGHGHGHGH SHSTTPTLGE RRNANAADDV NDLATQRTIT NYDPRRRLRT TLSGPTKLAQ 

      1870       1880       1890 
SADHAHAHSS QNLNGYVLAD SSSSCPTIPN TTQ 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 14024-0371.13.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH902617 Genomic DNA. Translation: EDV43181.1.
RefSeqXP_001954620.1. XM_001954584.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7217.FBpp0121553.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0123061; FBpp0121553; FBgn0095379.
GeneID6501137.
KEGGdan:Dana_GF18361.

Organism-specific databases

FlyBaseFBgn0095379. Dana\GF18361.

Phylogenomic databases

eggNOGNOG294902.
InParanoidB3M0V2.
KOK11427.
OrthoDBEOG7W6WJV.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3M0V2_DROAN
AccessionPrimary (citable) accession number: B3M0V2
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)