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B3LXF2

- DGKH_DROAN

UniProt

B3LXF2 - DGKH_DROAN

Protein

Diacylglycerol kinase eta

Gene

GF18176

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    3. protein oligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
    Short name:
    DAG kinase etaBy similarity
    Gene namesi
    ORF Names:GF18176
    OrganismiDrosophila ananassae (Fruit fly)
    Taxonomic identifieri7217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007801: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0095194. Dana\GF18176.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19161916Diacylglycerol kinase etaPRO_0000375984Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi7217.FBpp0121368.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 17594PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Domaini1853 – 191664SAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG328046.
    InParanoidiB3LXF2.
    KOiK00901.
    OrthoDBiEOG7DVD9B.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3LXF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHIKLDTLD VVQRPGTTRR SNSNSGRSSA CSSGSLSPVP IIPIIAISRD     50
    TDDSESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR 100
    RRYFRLKRNV LFHAKDFQCD VLDEIDLSDL CYFECGIKNV NHSSQIITPT 150
    RSLVLCAESR REMEDWLGSL KTATTPQRPR GDSFLIEQHD ILSNHHHWYA 200
    TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
    ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS VCAVCKKTCG SVLRLQDWRC 300
    LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
    NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
    HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
    WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIAV PKTPKMSITT 500
    EQEALLTGMV TSANHHLRFI VETNDTQTLI SSTQSLCDTI DDLVGRISEH 550
    HREDEQLAVK CDILRQKLNM LLDALQEEEM GAHSGDDLIA TIRSLIARSI 600
    PQTPGTSAPL LNPSISIEKN EKDEINTKER RSSRSLRSSE KEALQSRANS 650
    VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG DSTPCSSPLP 700
    IIPPINIISP TMETSRLTCI SPLPDTRRDS VDESFFNSIS LPAPRQFADS 750
    RRSSGVPDVI QEIEEGANGE TVYRIGRMSL SGGANIDDAG NRLSPCSDGG 800
    ENTPTERKVD FLRVPILTGE PIVDPLSDYR PIEVFERTYY MNRELDRGKE 850
    GTEEKKGDIE KEKSSGTDVE KEDNMPTEKQ ALVHICNLQV PGIVVTPNSQ 900
    NVYTSASLTI IDTDAQTTNE QSSSEEIAGE ASDVLSAISN EECSVASEIF 950
    DKQDAGHTLG DIIQSLDASN FTHIDSPETS DETEAMPGES IMDDISSVLG 1000
    HDITYALQDN TLTDDTTTLC SEHVGPPKPP RKKSLSALTR GHSHPRRRNS 1050
    SPPRIPRLAR MDSDDNPQQF GFENIVFEID NRCDDQKMRE PPRYCSLAQF 1100
    VEGNDIARQS FKQLMLEQHG SNDNDTEYPE QQTPTNTMTN LMATTSEDEL 1150
    STQTAIKIEI QDVDATMVRN INSSMKANTI LTTSTSPTKK SGHGQDISVV 1200
    VRPPTPLRGD SVKPSGSLLL DGSGGAISMA MGCSSLLGVR AMNAEIRRHS 1250
    SHAPGLAVRE IDKDKDRRHS GFNPNLLTLD PEHARFLSSS PAASRRISCG 1300
    SLFKKNQKIA TKRGYGLFSV RFLVVAEPDI RLATLALIRP LIPLPNEALP 1350
    NLQTLKGSKS SLFMGSTLFG FDQFAAGDKE KDEKGCKDKE KTPTEETGRK 1400
    LPIINPLVRL PNWPNLANGG GFISKCLLAN ADTLCAAVSP LMDPDETLLA 1450
    GYHEKCVMNN YFGIGIDAKI SLDFHNKREE HPEKCRSRAR NYMWYGVLGS 1500
    KQLLQKTCKN LEQRVQLECD GQRIPLPELQ GIVILNIPSF MGGTNFWGSS 1550
    TKKDDIFLPP SFDDRVLEVV AVFGSVQMAA SRLINLQHHR IAQCQSVQIN 1600
    ILGDEEIPIQ VDGEAWLQPP GMIRILHKNR VQMLCRNRSL ELSLKSWQEK 1650
    QRQHSISIQR DTSSTTSEHA TSTDEVISER ECYVLLNFIE AVSSLVKWVK 1700
    FLIISHPALQ HDLYAVACRA SEALESIHPQ GKLLEGPSLR TKLVEVIDSS 1750
    RQLYDDACTL LRDRGHSLIL REDLETKLSA ALANMEMELK KCSVQKCIDG 1800
    KLRAYFNVLA PNEEPDARRK SRPFWVRLRS GSTAGQQAFK PPLTNTREAA 1850
    NNWSVNEVVT WLETMQLSEY VDSFLKNDIR GKELITLGRR DLKDLGVVKV 1900
    GHVKRILQAI KDLSEN 1916
    Length:1,916
    Mass (Da):213,112
    Last modified:May 26, 2009 - v2
    Checksum:iE49E3E9A4D283BA2
    GO

    Sequence cautioni

    The sequence EDV42796.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902617 Genomic DNA. Translation: EDV42796.1. Sequence problems.
    RefSeqiXP_001954235.1. XM_001954199.1.

    Genome annotation databases

    GeneIDi6500954.
    KEGGidan:Dana_GF18176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902617 Genomic DNA. Translation: EDV42796.1 . Sequence problems.
    RefSeqi XP_001954235.1. XM_001954199.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7217.FBpp0121368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6500954.
    KEGGi dan:Dana_GF18176.

    Organism-specific databases

    FlyBasei FBgn0095194. Dana\GF18176.

    Phylogenomic databases

    eggNOGi NOG328046.
    InParanoidi B3LXF2.
    KOi K00901.
    OrthoDBi EOG7DVD9B.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14024-0371.13Imported.

    Entry informationi

    Entry nameiDGKH_DROAN
    AccessioniPrimary (citable) accession number: B3LXF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3