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B3LXF2

- DGKH_DROAN

UniProt

B3LXF2 - DGKH_DROAN

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Protein

Diacylglycerol kinase eta

Gene

GF18176

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GF18176
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0095194. Dana\GF18176.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19161916Diacylglycerol kinase etaPRO_0000375984Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0121368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHPROSITE-ProRule annotationAdd
BLAST
Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
BLAST
Domaini1853 – 191664SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
InParanoidiB3LXF2.
KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3LXF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHIKLDTLD VVQRPGTTRR SNSNSGRSSA CSSGSLSPVP IIPIIAISRD
60 70 80 90 100
TDDSESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR
110 120 130 140 150
RRYFRLKRNV LFHAKDFQCD VLDEIDLSDL CYFECGIKNV NHSSQIITPT
160 170 180 190 200
RSLVLCAESR REMEDWLGSL KTATTPQRPR GDSFLIEQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL
260 270 280 290 300
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS VCAVCKKTCG SVLRLQDWRC
310 320 330 340 350
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG
360 370 380 390 400
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR
410 420 430 440 450
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG
460 470 480 490 500
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIAV PKTPKMSITT
510 520 530 540 550
EQEALLTGMV TSANHHLRFI VETNDTQTLI SSTQSLCDTI DDLVGRISEH
560 570 580 590 600
HREDEQLAVK CDILRQKLNM LLDALQEEEM GAHSGDDLIA TIRSLIARSI
610 620 630 640 650
PQTPGTSAPL LNPSISIEKN EKDEINTKER RSSRSLRSSE KEALQSRANS
660 670 680 690 700
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG DSTPCSSPLP
710 720 730 740 750
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDESFFNSIS LPAPRQFADS
760 770 780 790 800
RRSSGVPDVI QEIEEGANGE TVYRIGRMSL SGGANIDDAG NRLSPCSDGG
810 820 830 840 850
ENTPTERKVD FLRVPILTGE PIVDPLSDYR PIEVFERTYY MNRELDRGKE
860 870 880 890 900
GTEEKKGDIE KEKSSGTDVE KEDNMPTEKQ ALVHICNLQV PGIVVTPNSQ
910 920 930 940 950
NVYTSASLTI IDTDAQTTNE QSSSEEIAGE ASDVLSAISN EECSVASEIF
960 970 980 990 1000
DKQDAGHTLG DIIQSLDASN FTHIDSPETS DETEAMPGES IMDDISSVLG
1010 1020 1030 1040 1050
HDITYALQDN TLTDDTTTLC SEHVGPPKPP RKKSLSALTR GHSHPRRRNS
1060 1070 1080 1090 1100
SPPRIPRLAR MDSDDNPQQF GFENIVFEID NRCDDQKMRE PPRYCSLAQF
1110 1120 1130 1140 1150
VEGNDIARQS FKQLMLEQHG SNDNDTEYPE QQTPTNTMTN LMATTSEDEL
1160 1170 1180 1190 1200
STQTAIKIEI QDVDATMVRN INSSMKANTI LTTSTSPTKK SGHGQDISVV
1210 1220 1230 1240 1250
VRPPTPLRGD SVKPSGSLLL DGSGGAISMA MGCSSLLGVR AMNAEIRRHS
1260 1270 1280 1290 1300
SHAPGLAVRE IDKDKDRRHS GFNPNLLTLD PEHARFLSSS PAASRRISCG
1310 1320 1330 1340 1350
SLFKKNQKIA TKRGYGLFSV RFLVVAEPDI RLATLALIRP LIPLPNEALP
1360 1370 1380 1390 1400
NLQTLKGSKS SLFMGSTLFG FDQFAAGDKE KDEKGCKDKE KTPTEETGRK
1410 1420 1430 1440 1450
LPIINPLVRL PNWPNLANGG GFISKCLLAN ADTLCAAVSP LMDPDETLLA
1460 1470 1480 1490 1500
GYHEKCVMNN YFGIGIDAKI SLDFHNKREE HPEKCRSRAR NYMWYGVLGS
1510 1520 1530 1540 1550
KQLLQKTCKN LEQRVQLECD GQRIPLPELQ GIVILNIPSF MGGTNFWGSS
1560 1570 1580 1590 1600
TKKDDIFLPP SFDDRVLEVV AVFGSVQMAA SRLINLQHHR IAQCQSVQIN
1610 1620 1630 1640 1650
ILGDEEIPIQ VDGEAWLQPP GMIRILHKNR VQMLCRNRSL ELSLKSWQEK
1660 1670 1680 1690 1700
QRQHSISIQR DTSSTTSEHA TSTDEVISER ECYVLLNFIE AVSSLVKWVK
1710 1720 1730 1740 1750
FLIISHPALQ HDLYAVACRA SEALESIHPQ GKLLEGPSLR TKLVEVIDSS
1760 1770 1780 1790 1800
RQLYDDACTL LRDRGHSLIL REDLETKLSA ALANMEMELK KCSVQKCIDG
1810 1820 1830 1840 1850
KLRAYFNVLA PNEEPDARRK SRPFWVRLRS GSTAGQQAFK PPLTNTREAA
1860 1870 1880 1890 1900
NNWSVNEVVT WLETMQLSEY VDSFLKNDIR GKELITLGRR DLKDLGVVKV
1910
GHVKRILQAI KDLSEN
Length:1,916
Mass (Da):213,112
Last modified:May 26, 2009 - v2
Checksum:iE49E3E9A4D283BA2
GO

Sequence cautioni

The sequence EDV42796.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV42796.1. Sequence problems.
RefSeqiXP_001954235.1. XM_001954199.1.

Genome annotation databases

GeneIDi6500954.
KEGGidan:Dana_GF18176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV42796.1 . Sequence problems.
RefSeqi XP_001954235.1. XM_001954199.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0121368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6500954.
KEGGi dan:Dana_GF18176.

Organism-specific databases

FlyBasei FBgn0095194. Dana\GF18176.

Phylogenomic databases

eggNOGi NOG328046.
InParanoidi B3LXF2.
KOi K00901.
OrthoDBi EOG7DVD9B.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13Imported.

Entry informationi

Entry nameiDGKH_DROAN
AccessioniPrimary (citable) accession number: B3LXF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3