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B3LXF2

- DGKH_DROAN

UniProt

B3LXF2 - DGKH_DROAN

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Protein
Diacylglycerol kinase eta
Gene
GF18176
Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) By similarity.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. diacylglycerol kinase activity Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Gene namesi
ORF Names:GF18176
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0095194. Dana\GF18176.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19161916Diacylglycerol kinase eta
PRO_0000375984Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0121368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PH
Add
BLAST
Domaini350 – 486137DAGKc
Add
BLAST
Domaini1853 – 191664SAM
Add
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
InParanoidiB3LXF2.
KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3LXF2-1 [UniParc]FASTAAdd to Basket

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MAHIKLDTLD VVQRPGTTRR SNSNSGRSSA CSSGSLSPVP IIPIIAISRD     50
TDDSESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR 100
RRYFRLKRNV LFHAKDFQCD VLDEIDLSDL CYFECGIKNV NHSSQIITPT 150
RSLVLCAESR REMEDWLGSL KTATTPQRPR GDSFLIEQHD ILSNHHHWYA 200
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS VCAVCKKTCG SVLRLQDWRC 300
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIAV PKTPKMSITT 500
EQEALLTGMV TSANHHLRFI VETNDTQTLI SSTQSLCDTI DDLVGRISEH 550
HREDEQLAVK CDILRQKLNM LLDALQEEEM GAHSGDDLIA TIRSLIARSI 600
PQTPGTSAPL LNPSISIEKN EKDEINTKER RSSRSLRSSE KEALQSRANS 650
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTTASG DSTPCSSPLP 700
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDESFFNSIS LPAPRQFADS 750
RRSSGVPDVI QEIEEGANGE TVYRIGRMSL SGGANIDDAG NRLSPCSDGG 800
ENTPTERKVD FLRVPILTGE PIVDPLSDYR PIEVFERTYY MNRELDRGKE 850
GTEEKKGDIE KEKSSGTDVE KEDNMPTEKQ ALVHICNLQV PGIVVTPNSQ 900
NVYTSASLTI IDTDAQTTNE QSSSEEIAGE ASDVLSAISN EECSVASEIF 950
DKQDAGHTLG DIIQSLDASN FTHIDSPETS DETEAMPGES IMDDISSVLG 1000
HDITYALQDN TLTDDTTTLC SEHVGPPKPP RKKSLSALTR GHSHPRRRNS 1050
SPPRIPRLAR MDSDDNPQQF GFENIVFEID NRCDDQKMRE PPRYCSLAQF 1100
VEGNDIARQS FKQLMLEQHG SNDNDTEYPE QQTPTNTMTN LMATTSEDEL 1150
STQTAIKIEI QDVDATMVRN INSSMKANTI LTTSTSPTKK SGHGQDISVV 1200
VRPPTPLRGD SVKPSGSLLL DGSGGAISMA MGCSSLLGVR AMNAEIRRHS 1250
SHAPGLAVRE IDKDKDRRHS GFNPNLLTLD PEHARFLSSS PAASRRISCG 1300
SLFKKNQKIA TKRGYGLFSV RFLVVAEPDI RLATLALIRP LIPLPNEALP 1350
NLQTLKGSKS SLFMGSTLFG FDQFAAGDKE KDEKGCKDKE KTPTEETGRK 1400
LPIINPLVRL PNWPNLANGG GFISKCLLAN ADTLCAAVSP LMDPDETLLA 1450
GYHEKCVMNN YFGIGIDAKI SLDFHNKREE HPEKCRSRAR NYMWYGVLGS 1500
KQLLQKTCKN LEQRVQLECD GQRIPLPELQ GIVILNIPSF MGGTNFWGSS 1550
TKKDDIFLPP SFDDRVLEVV AVFGSVQMAA SRLINLQHHR IAQCQSVQIN 1600
ILGDEEIPIQ VDGEAWLQPP GMIRILHKNR VQMLCRNRSL ELSLKSWQEK 1650
QRQHSISIQR DTSSTTSEHA TSTDEVISER ECYVLLNFIE AVSSLVKWVK 1700
FLIISHPALQ HDLYAVACRA SEALESIHPQ GKLLEGPSLR TKLVEVIDSS 1750
RQLYDDACTL LRDRGHSLIL REDLETKLSA ALANMEMELK KCSVQKCIDG 1800
KLRAYFNVLA PNEEPDARRK SRPFWVRLRS GSTAGQQAFK PPLTNTREAA 1850
NNWSVNEVVT WLETMQLSEY VDSFLKNDIR GKELITLGRR DLKDLGVVKV 1900
GHVKRILQAI KDLSEN 1916
Length:1,916
Mass (Da):213,112
Last modified:May 26, 2009 - v2
Checksum:iE49E3E9A4D283BA2
GO

Sequence cautioni

The sequence EDV42796.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV42796.1. Sequence problems.
RefSeqiXP_001954235.1. XM_001954199.1.

Genome annotation databases

GeneIDi6500954.
KEGGidan:Dana_GF18176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV42796.1 . Sequence problems.
RefSeqi XP_001954235.1. XM_001954199.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0121368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6500954.
KEGGi dan:Dana_GF18176.

Organism-specific databases

FlyBasei FBgn0095194. Dana\GF18176.

Phylogenomic databases

eggNOGi NOG328046.
InParanoidi B3LXF2.
KOi K00901.
OrthoDBi EOG7DVD9B.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiDGKH_DROAN
AccessioniPrimary (citable) accession number: B3LXF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi