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B3LVW5

- PDE6_DROAN

UniProt

B3LVW5 - PDE6_DROAN

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei746 – 7461Proton donorBy similarity
    Metal bindingi750 – 7501Divalent metal cation 1By similarity
    Metal bindingi786 – 7861Divalent metal cation 1By similarity
    Metal bindingi787 – 7871Divalent metal cation 1By similarity
    Metal bindingi787 – 7871Divalent metal cation 2By similarity
    Metal bindingi897 – 8971Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GF17478
    OrganismiDrosophila ananassae (Fruit fly)
    Taxonomic identifieri7217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000007801: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0094496. Dana\GF17478.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11551155cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363684Add
    BLAST
    Propeptidei1156 – 11583Removed in mature formBy similarityPRO_0000363685

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1155 – 11551Cysteine methyl esterBy similarity
    Lipidationi1155 – 11551S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Protein-protein interaction databases

    STRINGi7217.FBpp0120670.

    Structurei

    3D structure databases

    ProteinModelPortaliB3LVW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini242 – 394153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini426 – 640215GAF 2Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 6940Ala-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG270709.
    InParanoidiB3LVW5.
    KOiK13763.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB3LVW5.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 4 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B3LVW5-1 [UniParc]FASTAAdd to Basket

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    MTDVSAPTGG ATSPVDITAS PGSTALPPVA TTSAAASASS SQAKPLTNGA     50
    KKAATAAAAA GAEEGGASAS NQVKQEQRRQ SNNNRPAASG TPEAKQATPA 100
    GNPDPGAGST SKSSSIHTQT SQQERAGRPT SSASQHDVDE VARLFEEKPE 150
    AFEKWLTERA PPEALGRLQE FIESRKPLKR PSVTSDLFQQ WMAASPTVQQ 200
    KSPRSLSNSS ASSIPESRRH LMDLDEGELF MELIRDVANE LDIDVLCHKI 250
    LVNVGLLTHA DRGSLFLAKG APNNKYLVAK LFDVTQKTAL KDAVTRASTE 300
    EIIIPFGIGI AGMVAQTKQM INIKEAYKDA RFNCEIDLKT GYKTNAILCM 350
    PICNYEGDII GVAQIINKTN GCMEFDEHDV EIFRRYLTFC GIGIQNAQLF 400
    EMSVQEYRRN QILLNLARSI FEEQNNLECL VTKIMTEARE LLKCERCSVF 450
    LVDLDCCEAG CGRVGGAMRR FGVRSKQVSA IVEHVGGRRG NTSHLEKIIE 500
    KPNQPATRAI KSADSFEEKK MRNRFTVLFE LGGEYQAANV SRPSTSELST 550
    STLAQIAQFV ATTGQTVNIC DVHEWVREHN QIRAESEIDS TQAILCMPIV 600
    NAKKTVIGVA QLINKANGVP FTESDASIFE AFAIFCGLGI HNTQMYENAC 650
    KLMAKQKVAL ECLSYHATAS QDQTEKLTQD AIADADTYNL YSFTFTDFEL 700
    VDDDTCRAVL RMFMQCNLVS QFQIPYDVLC RWVLSVRKNY RPVKYHNWRH 750
    ALNVAQTMFA MLKTGKMERF MTDLEILGLL VACLCHDLDH RGTNNAFQTK 800
    TESPLAILYT TSTMEHHHFD QCVMILNSEG NNIFQALSPE DYRSVMKTVE 850
    SAILSTDLAM YFKKRNAFLE LVENGEFDWQ GEEKKDLLCG MMMTACDVSA 900
    IAKPWEVQHK VAKLVADEFF DQGDLEKLQL NTQPVAMMDR ERKDELPKMQ 950
    VGFIDVICLP LYRVLCDTFP WITPLYEGTL ENRRNWQDLA EKVEMGLTWI 1000
    DHDTIDKPVE EFAACADEEI KDIEFTVTTL NCNQSQQSQH GSEDSHTPEH 1050
    QRSGSRLSMK KTGALGKAVR SKLSKTLYNS MDGSKPKTSL KLLESHVSED 1100
    MDDKSPTSPS QPQAAGSMGR MSASSSTSSA GGQGQCQVAA PGQAQDKSKK 1150
    RSKLCALL 1158
    Length:1,158
    Mass (Da):127,966
    Last modified:September 2, 2008 - v1
    Checksum:i977DCAE9614F1792
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902617 Genomic DNA. Translation: EDV41498.1.
    RefSeqiXP_001952915.1. XM_001952880.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0122178; FBpp0120670; FBgn0094496.
    GeneIDi6500262.
    KEGGidan:Dana_GF17478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH902617 Genomic DNA. Translation: EDV41498.1 .
    RefSeqi XP_001952915.1. XM_001952880.1.

    3D structure databases

    ProteinModelPortali B3LVW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7217.FBpp0120670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0122178 ; FBpp0120670 ; FBgn0094496 .
    GeneIDi 6500262.
    KEGGi dan:Dana_GF17478.

    Organism-specific databases

    FlyBasei FBgn0094496. Dana\GF17478.

    Phylogenomic databases

    eggNOGi NOG270709.
    InParanoidi B3LVW5.
    KOi K13763.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B3LVW5.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 4 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14024-0371.13Imported.

    Entry informationi

    Entry nameiPDE6_DROAN
    AccessioniPrimary (citable) accession number: B3LVW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3