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B3LVW5

- PDE6_DROAN

UniProt

B3LVW5 - PDE6_DROAN

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Protein
cGMP-specific 3',5'-cyclic phosphodiesterase
Gene
Pde6, GF17478
Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei746 – 7461Proton donor By similarity
Metal bindingi750 – 7501Divalent metal cation 1 By similarity
Metal bindingi786 – 7861Divalent metal cation 1 By similarity
Metal bindingi787 – 7871Divalent metal cation 1 By similarity
Metal bindingi787 – 7871Divalent metal cation 2 By similarity
Metal bindingi897 – 8971Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GF17478
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0094496. Dana\GF17478.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11551155cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity
PRO_0000363684Add
BLAST
Propeptidei1156 – 11583Removed in mature form By similarityBy similarity
PRO_0000363685

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1155 – 11551Cysteine methyl ester By similarityBy similarity
Lipidationi1155 – 11551S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0120670.

Structurei

3D structure databases

ProteinModelPortaliB3LVW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini242 – 394153GAF 1
Add
BLAST
Domaini426 – 640215GAF 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 6940Ala-rich
Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiB3LVW5.
KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB3LVW5.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 4 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3LVW5-1 [UniParc]FASTAAdd to Basket

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MTDVSAPTGG ATSPVDITAS PGSTALPPVA TTSAAASASS SQAKPLTNGA     50
KKAATAAAAA GAEEGGASAS NQVKQEQRRQ SNNNRPAASG TPEAKQATPA 100
GNPDPGAGST SKSSSIHTQT SQQERAGRPT SSASQHDVDE VARLFEEKPE 150
AFEKWLTERA PPEALGRLQE FIESRKPLKR PSVTSDLFQQ WMAASPTVQQ 200
KSPRSLSNSS ASSIPESRRH LMDLDEGELF MELIRDVANE LDIDVLCHKI 250
LVNVGLLTHA DRGSLFLAKG APNNKYLVAK LFDVTQKTAL KDAVTRASTE 300
EIIIPFGIGI AGMVAQTKQM INIKEAYKDA RFNCEIDLKT GYKTNAILCM 350
PICNYEGDII GVAQIINKTN GCMEFDEHDV EIFRRYLTFC GIGIQNAQLF 400
EMSVQEYRRN QILLNLARSI FEEQNNLECL VTKIMTEARE LLKCERCSVF 450
LVDLDCCEAG CGRVGGAMRR FGVRSKQVSA IVEHVGGRRG NTSHLEKIIE 500
KPNQPATRAI KSADSFEEKK MRNRFTVLFE LGGEYQAANV SRPSTSELST 550
STLAQIAQFV ATTGQTVNIC DVHEWVREHN QIRAESEIDS TQAILCMPIV 600
NAKKTVIGVA QLINKANGVP FTESDASIFE AFAIFCGLGI HNTQMYENAC 650
KLMAKQKVAL ECLSYHATAS QDQTEKLTQD AIADADTYNL YSFTFTDFEL 700
VDDDTCRAVL RMFMQCNLVS QFQIPYDVLC RWVLSVRKNY RPVKYHNWRH 750
ALNVAQTMFA MLKTGKMERF MTDLEILGLL VACLCHDLDH RGTNNAFQTK 800
TESPLAILYT TSTMEHHHFD QCVMILNSEG NNIFQALSPE DYRSVMKTVE 850
SAILSTDLAM YFKKRNAFLE LVENGEFDWQ GEEKKDLLCG MMMTACDVSA 900
IAKPWEVQHK VAKLVADEFF DQGDLEKLQL NTQPVAMMDR ERKDELPKMQ 950
VGFIDVICLP LYRVLCDTFP WITPLYEGTL ENRRNWQDLA EKVEMGLTWI 1000
DHDTIDKPVE EFAACADEEI KDIEFTVTTL NCNQSQQSQH GSEDSHTPEH 1050
QRSGSRLSMK KTGALGKAVR SKLSKTLYNS MDGSKPKTSL KLLESHVSED 1100
MDDKSPTSPS QPQAAGSMGR MSASSSTSSA GGQGQCQVAA PGQAQDKSKK 1150
RSKLCALL 1158
Length:1,158
Mass (Da):127,966
Last modified:September 2, 2008 - v1
Checksum:i977DCAE9614F1792
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV41498.1.
RefSeqiXP_001952915.1. XM_001952880.1.

Genome annotation databases

EnsemblMetazoaiFBtr0122178; FBpp0120670; FBgn0094496.
GeneIDi6500262.
KEGGidan:Dana_GF17478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV41498.1 .
RefSeqi XP_001952915.1. XM_001952880.1.

3D structure databases

ProteinModelPortali B3LVW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0120670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0122178 ; FBpp0120670 ; FBgn0094496 .
GeneIDi 6500262.
KEGGi dan:Dana_GF17478.

Organism-specific databases

FlyBasei FBgn0094496. Dana\GF17478.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi B3LVW5.
KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B3LVW5.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 4 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13.

Entry informationi

Entry nameiPDE6_DROAN
AccessioniPrimary (citable) accession number: B3LVW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi