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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei746Proton donorBy similarity1
Metal bindingi750Divalent metal cation 1By similarity1
Metal bindingi786Divalent metal cation 1By similarity1
Metal bindingi787Divalent metal cation 1By similarity1
Metal bindingi787Divalent metal cation 2By similarity1
Metal bindingi897Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GF17478
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007801 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0094496 Dana\GF17478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003636841 – 1155cGMP-specific 3',5'-cyclic phosphodiesteraseAdd BLAST1155
PropeptideiPRO_00003636851156 – 1158Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1155Cysteine methyl esterBy similarity1
Lipidationi1155S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiB3LVW5

Expressioni

Gene expression databases

BgeeiFBgn0094496

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0120670

Structurei

3D structure databases

ProteinModelPortaliB3LVW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 394GAF 1Sequence analysisAdd BLAST153
Domaini426 – 640GAF 2Sequence analysisAdd BLAST215
Domaini670 – 993PDEasePROSITE-ProRule annotationAdd BLAST324

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 69Ala-richSequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
InParanoidiB3LVW5
KOiK13763
OMAiATIRMFK
OrthoDBiEOG091G04JU
PhylomeDBiB3LVW5

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 1 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3LVW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVSAPTGG ATSPVDITAS PGSTALPPVA TTSAAASASS SQAKPLTNGA
60 70 80 90 100
KKAATAAAAA GAEEGGASAS NQVKQEQRRQ SNNNRPAASG TPEAKQATPA
110 120 130 140 150
GNPDPGAGST SKSSSIHTQT SQQERAGRPT SSASQHDVDE VARLFEEKPE
160 170 180 190 200
AFEKWLTERA PPEALGRLQE FIESRKPLKR PSVTSDLFQQ WMAASPTVQQ
210 220 230 240 250
KSPRSLSNSS ASSIPESRRH LMDLDEGELF MELIRDVANE LDIDVLCHKI
260 270 280 290 300
LVNVGLLTHA DRGSLFLAKG APNNKYLVAK LFDVTQKTAL KDAVTRASTE
310 320 330 340 350
EIIIPFGIGI AGMVAQTKQM INIKEAYKDA RFNCEIDLKT GYKTNAILCM
360 370 380 390 400
PICNYEGDII GVAQIINKTN GCMEFDEHDV EIFRRYLTFC GIGIQNAQLF
410 420 430 440 450
EMSVQEYRRN QILLNLARSI FEEQNNLECL VTKIMTEARE LLKCERCSVF
460 470 480 490 500
LVDLDCCEAG CGRVGGAMRR FGVRSKQVSA IVEHVGGRRG NTSHLEKIIE
510 520 530 540 550
KPNQPATRAI KSADSFEEKK MRNRFTVLFE LGGEYQAANV SRPSTSELST
560 570 580 590 600
STLAQIAQFV ATTGQTVNIC DVHEWVREHN QIRAESEIDS TQAILCMPIV
610 620 630 640 650
NAKKTVIGVA QLINKANGVP FTESDASIFE AFAIFCGLGI HNTQMYENAC
660 670 680 690 700
KLMAKQKVAL ECLSYHATAS QDQTEKLTQD AIADADTYNL YSFTFTDFEL
710 720 730 740 750
VDDDTCRAVL RMFMQCNLVS QFQIPYDVLC RWVLSVRKNY RPVKYHNWRH
760 770 780 790 800
ALNVAQTMFA MLKTGKMERF MTDLEILGLL VACLCHDLDH RGTNNAFQTK
810 820 830 840 850
TESPLAILYT TSTMEHHHFD QCVMILNSEG NNIFQALSPE DYRSVMKTVE
860 870 880 890 900
SAILSTDLAM YFKKRNAFLE LVENGEFDWQ GEEKKDLLCG MMMTACDVSA
910 920 930 940 950
IAKPWEVQHK VAKLVADEFF DQGDLEKLQL NTQPVAMMDR ERKDELPKMQ
960 970 980 990 1000
VGFIDVICLP LYRVLCDTFP WITPLYEGTL ENRRNWQDLA EKVEMGLTWI
1010 1020 1030 1040 1050
DHDTIDKPVE EFAACADEEI KDIEFTVTTL NCNQSQQSQH GSEDSHTPEH
1060 1070 1080 1090 1100
QRSGSRLSMK KTGALGKAVR SKLSKTLYNS MDGSKPKTSL KLLESHVSED
1110 1120 1130 1140 1150
MDDKSPTSPS QPQAAGSMGR MSASSSTSSA GGQGQCQVAA PGQAQDKSKK

RSKLCALL
Length:1,158
Mass (Da):127,966
Last modified:September 2, 2008 - v1
Checksum:i977DCAE9614F1792
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902617 Genomic DNA Translation: EDV41498.1
RefSeqiXP_001952915.2, XM_001952880.2

Genome annotation databases

GeneIDi6500262
KEGGidan:Dana_GF17478

Similar proteinsi

Entry informationi

Entry nameiPDE6_DROAN
AccessioniPrimary (citable) accession number: B3LVW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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