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B3LVW5

- PDE6_DROAN

UniProt

B3LVW5 - PDE6_DROAN

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei746 – 7461Proton donorBy similarity
Metal bindingi750 – 7501Divalent metal cation 1By similarity
Metal bindingi786 – 7861Divalent metal cation 1By similarity
Metal bindingi787 – 7871Divalent metal cation 1By similarity
Metal bindingi787 – 7871Divalent metal cation 2By similarity
Metal bindingi897 – 8971Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GF17478
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000007801: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0094496. Dana\GF17478.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11551155cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363684Add
BLAST
Propeptidei1156 – 11583Removed in mature formBy similarityPRO_0000363685

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1155 – 11551Cysteine methyl esterBy similarity
Lipidationi1155 – 11551S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Protein-protein interaction databases

STRINGi7217.FBpp0120670.

Structurei

3D structure databases

ProteinModelPortaliB3LVW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini242 – 394153GAF 1Sequence AnalysisAdd
BLAST
Domaini426 – 640215GAF 2Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 6940Ala-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiB3LVW5.
KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB3LVW5.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 4 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B3LVW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVSAPTGG ATSPVDITAS PGSTALPPVA TTSAAASASS SQAKPLTNGA
60 70 80 90 100
KKAATAAAAA GAEEGGASAS NQVKQEQRRQ SNNNRPAASG TPEAKQATPA
110 120 130 140 150
GNPDPGAGST SKSSSIHTQT SQQERAGRPT SSASQHDVDE VARLFEEKPE
160 170 180 190 200
AFEKWLTERA PPEALGRLQE FIESRKPLKR PSVTSDLFQQ WMAASPTVQQ
210 220 230 240 250
KSPRSLSNSS ASSIPESRRH LMDLDEGELF MELIRDVANE LDIDVLCHKI
260 270 280 290 300
LVNVGLLTHA DRGSLFLAKG APNNKYLVAK LFDVTQKTAL KDAVTRASTE
310 320 330 340 350
EIIIPFGIGI AGMVAQTKQM INIKEAYKDA RFNCEIDLKT GYKTNAILCM
360 370 380 390 400
PICNYEGDII GVAQIINKTN GCMEFDEHDV EIFRRYLTFC GIGIQNAQLF
410 420 430 440 450
EMSVQEYRRN QILLNLARSI FEEQNNLECL VTKIMTEARE LLKCERCSVF
460 470 480 490 500
LVDLDCCEAG CGRVGGAMRR FGVRSKQVSA IVEHVGGRRG NTSHLEKIIE
510 520 530 540 550
KPNQPATRAI KSADSFEEKK MRNRFTVLFE LGGEYQAANV SRPSTSELST
560 570 580 590 600
STLAQIAQFV ATTGQTVNIC DVHEWVREHN QIRAESEIDS TQAILCMPIV
610 620 630 640 650
NAKKTVIGVA QLINKANGVP FTESDASIFE AFAIFCGLGI HNTQMYENAC
660 670 680 690 700
KLMAKQKVAL ECLSYHATAS QDQTEKLTQD AIADADTYNL YSFTFTDFEL
710 720 730 740 750
VDDDTCRAVL RMFMQCNLVS QFQIPYDVLC RWVLSVRKNY RPVKYHNWRH
760 770 780 790 800
ALNVAQTMFA MLKTGKMERF MTDLEILGLL VACLCHDLDH RGTNNAFQTK
810 820 830 840 850
TESPLAILYT TSTMEHHHFD QCVMILNSEG NNIFQALSPE DYRSVMKTVE
860 870 880 890 900
SAILSTDLAM YFKKRNAFLE LVENGEFDWQ GEEKKDLLCG MMMTACDVSA
910 920 930 940 950
IAKPWEVQHK VAKLVADEFF DQGDLEKLQL NTQPVAMMDR ERKDELPKMQ
960 970 980 990 1000
VGFIDVICLP LYRVLCDTFP WITPLYEGTL ENRRNWQDLA EKVEMGLTWI
1010 1020 1030 1040 1050
DHDTIDKPVE EFAACADEEI KDIEFTVTTL NCNQSQQSQH GSEDSHTPEH
1060 1070 1080 1090 1100
QRSGSRLSMK KTGALGKAVR SKLSKTLYNS MDGSKPKTSL KLLESHVSED
1110 1120 1130 1140 1150
MDDKSPTSPS QPQAAGSMGR MSASSSTSSA GGQGQCQVAA PGQAQDKSKK

RSKLCALL
Length:1,158
Mass (Da):127,966
Last modified:September 2, 2008 - v1
Checksum:i977DCAE9614F1792
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV41498.1.
RefSeqiXP_001952915.1. XM_001952880.1.

Genome annotation databases

EnsemblMetazoaiFBtr0122178; FBpp0120670; FBgn0094496.
GeneIDi6500262.
KEGGidan:Dana_GF17478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH902617 Genomic DNA. Translation: EDV41498.1 .
RefSeqi XP_001952915.1. XM_001952880.1.

3D structure databases

ProteinModelPortali B3LVW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7217.FBpp0120670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0122178 ; FBpp0120670 ; FBgn0094496 .
GeneIDi 6500262.
KEGGi dan:Dana_GF17478.

Organism-specific databases

FlyBasei FBgn0094496. Dana\GF17478.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi B3LVW5.
KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B3LVW5.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 4 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14024-0371.13Imported.

Entry informationi

Entry nameiPDE6_DROAN
AccessioniPrimary (citable) accession number: B3LVW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3