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Protein

Guanine nucleotide exchange factor SDC25

Gene

SDC25

Organism
Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Promotes the exchange of Ras-bound GDP by GTP.By similarity

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SDC25
Gene namesi
Name:SDC25
Synonyms:SCD25
ORF Names:SCRG_04972
OrganismiSaccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Taxonomic identifieri285006 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000008335 Componenti: Unassembled WGS sequence

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003934371 – 1252Guanine nucleotide exchange factor SDC25Add BLAST1252

Proteomic databases

PRIDEiB3LTF3

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB3LTF3
SMRiB3LTF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 97SH3PROSITE-ProRule annotationAdd BLAST72
Domaini782 – 914N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST133
Domaini952 – 1199Ras-GEFPROSITE-ProRule annotationAdd BLAST248

Keywords - Domaini

SH3 domain

Phylogenomic databases

OrthoDBiEOG092C0VYU

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 2 hits
InterProiView protein in InterPro
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

B3LTF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SQNKLSLRVG
60 70 80 90 100
DLIYVLTKGS NGWWDGVLIR HSANNNNNSL ILDRGWFPPS FTRSILNELH
110 120 130 140 150
GVPEIGNELE IFQAGLNLKL ELSSNPVILS LEDFLDCCRD IEFKEQLAWS
160 170 180 190 200
PIPVHERKGC CELLYYNQDL DVYCRTLPYL PQNQVETVND YSSFPAISKI
210 220 230 240 250
AGKKMPITSS PDLFYLNDCD VVYWYDLTRL VCHYVNLTER DLLANEREKF
260 270 280 290 300
LTSLDLLTAQ ITCVYMLFRN LRLVEDSFKK TLKKLIYTLS RFSINANIWF
310 320 330 340 350
HSTPFEEREA IASQKDPERR SPLLQSILGT FQKFHFLLRL LHFLSNPNEL
360 370 380 390 400
TILPQLTPRF FKDSFNTISW NNPFLRKHLN QHMSHDLPRQ MIKAVAGASG
410 420 430 440 450
IVAENNDEIP ASKQGTSCSS ETSHHSPSAP FQRRRRGTIF SNVPGSSDES
460 470 480 490 500
DTIWSKRKKP YPLNEETLSL VRARKEQLDA KLKQMIKSAN EYLSNTANFS
510 520 530 540 550
KMLNFEMNFK TYEEVSGTIP IIDILENLDL TIYLNLRELG DENRVFDEDV
560 570 580 590 600
AIDDEDKEFL KHSLSSLSYI LSDYFNMKQY FHDVVVKFII VAQHLTLEDP
610 620 630 640 650
FVFSPMQNDL PTGYYEPMKP SSLNLDNAKD KKNGSQNTDI QEEEDEYEPD
660 670 680 690 700
PDSLILFHNL INQDSDFNDL KFFNLAHVFK KSCDDYFDVL KLSIEFVNRL
710 720 730 740 750
ILERENLLNY AARMMKNNIT ELLLRGEEGY GSYDGGETAE KSDTNAVYAD
760 770 780 790 800
SDTKDNDEWR DSQVKLPRYL QREYDSELIW GSNNRIKGGS KHALISYLTD
810 820 830 840 850
NEKKDLFFNI TFLITFRSIF TTTEFLSYLI SQYNLDPPED LCFEEYNEWV
860 870 880 890 900
TKKLIPVKCR VVEIMTTFFK QYWFPGYDEP DLATLNLDYF AQVAIKENIT
910 920 930 940 950
GSVELLKEVN QKFKHGNMQE ATAPMKTLDQ QICQEHYWGT LYSTTESILA
960 970 980 990 1000
VDPVLFATQL TILEHEIYCE ITIFDCLQKI WKNKYTKSYG ASPGLNEFIS
1010 1020 1030 1040 1050
FANKLTNFIS YSIVKEADKS KRAKLLSHFI FIAEYCRKFN NFSSMTAIIS
1060 1070 1080 1090 1100
ALYSSSIYRL EKTWQAVIPQ TRDLLQSLDK LMDPKKNFIN YRSELKSLHS
1110 1120 1130 1140 1150
APCVPFFGVY LSDLTFTDSG NPDYLVLEHG LKGVHDEKKY INFNKRSRLV
1160 1170 1180 1190 1200
DILQEIIYFK KTHYDFTKDR TVIECISNSL ENIPHIEKQY QLSLIIEPKP
1210 1220 1230 1240 1250
RKKVVPNSNS NNKSQEKSRD DQTDEGKTST KKDRFSKFQL HKTKKKAPKV

SK
Length:1,252
Mass (Da):145,121
Last modified:September 2, 2008 - v1
Checksum:i31BB86C99DE2F721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408054 Genomic DNA Translation: EDV09296.1

Genome annotation databases

EnsemblFungiiEDV09296; EDV09296; SCRG_04972

Similar proteinsi

Entry informationi

Entry nameiSDC25_YEAS1
AccessioniPrimary (citable) accession number: B3LTF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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