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B3LTF3

- SDC25_YEAS1

UniProt

B3LTF3 - SDC25_YEAS1

Protein

Guanine nucleotide exchange factor SDC25

Gene

SDC25

Organism
Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Promotes the exchange of Ras-bound GDP by GTP.By similarity

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. regulation of small GTPase mediated signal transduction Source: InterPro
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide exchange factor SDC25
    Gene namesi
    Name:SDC25
    Synonyms:SCD25
    ORF Names:SCRG_04972
    OrganismiSaccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
    Taxonomic identifieri285006 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000008335: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12521252Guanine nucleotide exchange factor SDC25PRO_0000393437Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliB3LTF3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 9772SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini782 – 914133N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini952 – 1199248Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    OrthoDBiEOG78WM2F.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3LTF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SQNKLSLRVG     50
    DLIYVLTKGS NGWWDGVLIR HSANNNNNSL ILDRGWFPPS FTRSILNELH 100
    GVPEIGNELE IFQAGLNLKL ELSSNPVILS LEDFLDCCRD IEFKEQLAWS 150
    PIPVHERKGC CELLYYNQDL DVYCRTLPYL PQNQVETVND YSSFPAISKI 200
    AGKKMPITSS PDLFYLNDCD VVYWYDLTRL VCHYVNLTER DLLANEREKF 250
    LTSLDLLTAQ ITCVYMLFRN LRLVEDSFKK TLKKLIYTLS RFSINANIWF 300
    HSTPFEEREA IASQKDPERR SPLLQSILGT FQKFHFLLRL LHFLSNPNEL 350
    TILPQLTPRF FKDSFNTISW NNPFLRKHLN QHMSHDLPRQ MIKAVAGASG 400
    IVAENNDEIP ASKQGTSCSS ETSHHSPSAP FQRRRRGTIF SNVPGSSDES 450
    DTIWSKRKKP YPLNEETLSL VRARKEQLDA KLKQMIKSAN EYLSNTANFS 500
    KMLNFEMNFK TYEEVSGTIP IIDILENLDL TIYLNLRELG DENRVFDEDV 550
    AIDDEDKEFL KHSLSSLSYI LSDYFNMKQY FHDVVVKFII VAQHLTLEDP 600
    FVFSPMQNDL PTGYYEPMKP SSLNLDNAKD KKNGSQNTDI QEEEDEYEPD 650
    PDSLILFHNL INQDSDFNDL KFFNLAHVFK KSCDDYFDVL KLSIEFVNRL 700
    ILERENLLNY AARMMKNNIT ELLLRGEEGY GSYDGGETAE KSDTNAVYAD 750
    SDTKDNDEWR DSQVKLPRYL QREYDSELIW GSNNRIKGGS KHALISYLTD 800
    NEKKDLFFNI TFLITFRSIF TTTEFLSYLI SQYNLDPPED LCFEEYNEWV 850
    TKKLIPVKCR VVEIMTTFFK QYWFPGYDEP DLATLNLDYF AQVAIKENIT 900
    GSVELLKEVN QKFKHGNMQE ATAPMKTLDQ QICQEHYWGT LYSTTESILA 950
    VDPVLFATQL TILEHEIYCE ITIFDCLQKI WKNKYTKSYG ASPGLNEFIS 1000
    FANKLTNFIS YSIVKEADKS KRAKLLSHFI FIAEYCRKFN NFSSMTAIIS 1050
    ALYSSSIYRL EKTWQAVIPQ TRDLLQSLDK LMDPKKNFIN YRSELKSLHS 1100
    APCVPFFGVY LSDLTFTDSG NPDYLVLEHG LKGVHDEKKY INFNKRSRLV 1150
    DILQEIIYFK KTHYDFTKDR TVIECISNSL ENIPHIEKQY QLSLIIEPKP 1200
    RKKVVPNSNS NNKSQEKSRD DQTDEGKTST KKDRFSKFQL HKTKKKAPKV 1250
    SK 1252
    Length:1,252
    Mass (Da):145,121
    Last modified:September 2, 2008 - v1
    Checksum:i31BB86C99DE2F721
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408054 Genomic DNA. Translation: EDV09296.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408054 Genomic DNA. Translation: EDV09296.1 .

    3D structure databases

    ProteinModelPortali B3LTF3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG78WM2F.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RM11-1a.

    Entry informationi

    Entry nameiSDC25_YEAS1
    AccessioniPrimary (citable) accession number: B3LTF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3