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Protein

AP-2 complex subunit alpha

Gene

SCRG_03000

Organism
Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosisUniRule annotation, Protein transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit alphaUniRule annotation
Gene namesi
ORF Names:SCRG_03000Imported
OrganismiSaccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)Imported
Taxonomic identifieri285006 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000008335 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Coated pitUniRule annotation, Membrane

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini762 – 884Alpha_adaptinC2InterPro annotationAdd BLAST123

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 52Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the adaptor complexes large subunit family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

OrthoDBiEOG092C0BGI.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.30.310.10. 1 hit.
InterProiView protein in InterPro
IPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR013041. Clathrin_app_Ig-like_sf.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR012295. TBP_dom_sf.
PfamiView protein in Pfam
PF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiView protein in SMART
SM00809. Alpha_adaptinC2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

B3LNH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRKKTLINS SVSNNNSTIK GLQLFIADLR SAQQAQEQEK RIQSEIVKIK
60 70 80 90 100
QHFDAAKKKQ GNHDRLGGYQ RKKYVAKLAY IYITSNTTKL NEILFGLEQT
110 120 130 140 150
VELLKSSIFS EKFIGYMTLE LLYERSEVVA KVNDEVNYQL MKDLSSSDDN
160 170 180 190 200
FVMLALNFVG VVGELTNRLA YNDDITTGVF KILRSPTSSI YLKKKSALSF
210 220 230 240 250
LALLKSNHSI LTEDLQRKQL WIQRILSLLD DTENYRLTLA TIPLIDFIAK
260 270 280 290 300
YIDPSYCTRL LPQLTEILYN CVVVGTSRSS DNQFPLEYTF ANMPNPWLIT
310 320 330 340 350
KVVSLLSILI ASPTERDSGS LLQTNNIDNE LLNKLRKCVS VAIELGTRQA
360 370 380 390 400
QDPMERIVQN TVLFSLINFA SKLDPSDEAI SNSVTALCSL LTSKEINIRY
410 420 430 440 450
LTLDSLVKLC SSSGKPAIDA VRYKNLDMIF HLLNTERDSS IVRKVVDLLY
460 470 480 490 500
TFTDVENVKI IVDGLLQYIL SPKNLAEPQI KSDIAVKIAI LTEKYATDIN
510 520 530 540 550
WFVIISLQLL SLTSNTTIND DEIWQRLCQI VVNNPSLHRI TCERLVDYLC
560 570 580 590 600
KKQASEAIIK AAAFLLGEYS SLITDRISSA NLFTLFAEKY FSAPNVAKAM
610 620 630 640 650
ILTTMIKLYK TSPEIGSNVI KFFQLELNSL DIELQTRSFE YLNIIQLAKV
660 670 680 690 700
NGNTDILQIL FEPMPPFNSK SNPLLKRLGS LPASAGSTTL INTPSEASSS
710 720 730 740 750
TPDLLSKRAN SSRSIMVPMP PPSRRNTIDD ANSKISSSED FSGKDSYYSR
760 770 780 790 800
QILAPNWREG FTRMISHKQG VLFTSSLMKV FYRITTPDAQ QPYVFHISLA
810 820 830 840 850
FINLTEWEIT GLSTQIIPSK TQGNPEYLIL NINTPSTATI GPHKRAEQSY
860 870 880 890 900
EVSIRKPFDV EDSPILAIHF KCGGSTNTIN LKTAIGMTTT LISSDVNPSM
910 920 930 940 950
HLNLAQFISR WKTLSDALGK EGEYQKSGIK LNKDFRKVET ISLEDGLLLL
960 970 980 990 1000
TQTVKRLGFD IVDQTSVRST LFVSGIIHTK SEGNFGCLMK IQYQVNGSVN
1010 1020
VTCKTTTAGP LAKYIVECIK NVLTK
Length:1,025
Mass (Da):114,938
Last modified:September 2, 2008 - v1
Checksum:iA7AB4B1B656E530C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408048 Genomic DNA. Translation: EDV12128.1.

Genome annotation databases

EnsemblFungiiEDV12128; EDV12128; SCRG_03000.

Similar proteinsi

Entry informationi

Entry nameiB3LNH5_YEAS1
AccessioniPrimary (citable) accession number: B3LNH5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported