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Protein

Mitochondrial glycine transporter

Gene

SCRG_00613

Organism
Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:SCRG_00613
OrganismiSaccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Taxonomic identifieri285006 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000008335 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 39Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei62 – 88Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei121 – 146Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei174 – 197Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei225 – 251Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei280 – 298Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789471 – 307Mitochondrial glycine transporterAdd BLAST307

Proteomic databases

PRIDEiB3LH09

Structurei

3D structure databases

ProteinModelPortaliB3LH09
SMRiB3LH09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 87Solcar 1UniRule annotationAdd BLAST80
Repeati115 – 199Solcar 2UniRule annotationAdd BLAST85
Repeati221 – 305Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

B3LH09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQATKPRN SSHLIGGFFG GLTSAVALQP LDLLKTRIQQ DKKATLWKNL
60 70 80 90 100
KEIDSPLQLW RGTLPSALRT SIGSALYLSC LNLMRSSLAK RRNAVPSLTN
110 120 130 140 150
DSNIVYNKSS SLPRLTMYEN LLTGAFARGL VGYITMPITV IKVRYESTLY
160 170 180 190 200
NYSSLKEAIT HIYTKEGLFG FFRGFGATCL RDAPYAGLYV LLYEKSKQLL
210 220 230 240 250
PMVLPSRFIH YNPEGGFTTY TSTTVNTTSA VLSASLATTV TAPFDTIKTR
260 270 280 290 300
MQLEPSKFTN SFNTFTSIVK NENVLKLFSG LSMRLARKAL SAGIAWGIYE

ELVKRFM
Length:307
Mass (Da):34,170
Last modified:September 2, 2008 - v1
Checksum:i7445BC359E157C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408043 Genomic DNA Translation: EDV08388.1

Genome annotation databases

EnsemblFungiiEDV08388; EDV08388; SCRG_00613

Similar proteinsi

Entry informationi

Entry nameiS2538_YEAS1
AccessioniPrimary (citable) accession number: B3LH09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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