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Reviewed, UniProtKB/Swiss-Prot B3LG61 (KAD1_YEAS1)

Last modified February 9, 2010. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial
Gene names
Name: ADK1
ORF Names: SCRG_00298
OrganismSaccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Taxonomic identifier285006 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.

Catalytic activity

ATP + AMP = 2 ADP.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasmcytosol By similarity. Mitochondrion intermembrane space By similarity.

Sequence similarities

Belongs to the adenylate kinase family. AK2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 22Removed in mature form By similarity
PRO_0000365691
Chain3 – 222220Adenylate kinase 1
PRO_0000365692

Regions

Nucleotide binding13 – 219ATP By similarity
Nucleotide binding36 – 6530AMP By similarity

Sites

Binding site371AMP By similarity

Amino acid modifications

Modified residue31N-acetylserine By similarity
Modified residue1401Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
B3LG61-1 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: FE566FD8015907CE

FASTA22224,255
        10         20         30         40         50         60 
MSSSESIRMV LIGPPGAGKG TQAPNLQERF HAAHLATGDM LRSQIAKGTQ LGLEAKKIMD 

        70         80         90        100        110        120 
QGGLVSDDIM VNMIKDELTN NPACKNGFIL DGFPRTIPQA EKLDQMLKEQ GTPLEKAIEL 

       130        140        150        160        170        180 
KVDDELLVAR ITGRLIHPAS GRSYHKIFNP PKEDMKDDVT GEALVQRSDD NADALKKRLA 

       190        200        210        220 
AYHAQTEPIV DFYKKTGIWA GVDASQPPAT VWADILNKLG KD 

« Hide

References

[1]"Annotation of the Saccharomyces cerevisiae RM11-1a genome."
Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Cuomo C., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., MacCallum I.A., Rounsley S., Young S.K., LaButti K. expand/collapse author list , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., O'Leary S., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Pratt S., Kruglyak L.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408043 Genomic DNA. Translation: EDV08090.1.

3D structure databases

SMRB3LG61. Positions 5-222.
ModBaseSearch...

Family and domain databases

InterProIPR006259. Adenyl_kin_sub.
IPR000850. Adenylate_kin.
IPR007862. Adenylate_kinase_lid-dom.
[Graphical view]
PANTHERPTHR23359. Adenylate_kin. 1 hit.
PfamPF00406. ADK. 1 hit.
PF05191. ADK_lid. 1 hit.
[Graphical view]
PRINTSPR00094. ADENYLTKNASE.
TIGRFAMsTIGR01351. adk. 1 hit.
PROSITEPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAD1_YEAS1
AccessionPrimary (citable) accession number: B3LG61
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 2, 2008
Last modified: February 9, 2010
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents