Reviewed, UniProtKB/Swiss-Prot B3LG61 (KAD1_YEAS1)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	SCRG_00298

Organism

Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)

Taxonomic identifier

285006 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 2	2	Removed in mature form By similarity		PRO_0000365691
	Chain	3 – 222	220	Adenylate kinase 1		PRO_0000365692
Regions
	Nucleotide binding	13 – 21	9	ATP By similarity
	Nucleotide binding	36 – 65	30	AMP By similarity
Sites
	Binding site	37	1	AMP By similarity
Amino acid modifications
	Modified residue	3	1	N-acetylserine By similarity
	Modified residue	140	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B3LG61-1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: FE566FD8015907CE	FASTA	222	24,255
	10 20 30 40 50 60 MSSSESIRMV LIGPPGAGKG TQAPNLQERF HAAHLATGDM LRSQIAKGTQ LGLEAKKIMD 70 80 90 100 110 120 QGGLVSDDIM VNMIKDELTN NPACKNGFIL DGFPRTIPQA EKLDQMLKEQ GTPLEKAIEL 130 140 150 160 170 180 KVDDELLVAR ITGRLIHPAS GRSYHKIFNP PKEDMKDDVT GEALVQRSDD NADALKKRLA 190 200 210 220 AYHAQTEPIV DFYKKTGIWA GVDASQPPAT VWADILNKLG KD

References

[1]

"Annotation of the Saccharomyces cerevisiae RM11-1a genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Cuomo C., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., MacCallum I.A., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., O'Leary S., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Pratt S., Kruglyak L. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH408043 Genomic DNA. Translation: EDV08090.1.
3D structure databases
SMR	B3LG61. Positions 5-222.
ModBase	Search...
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_YEAS1

Accession

Primary (citable) accession number: B3LG61

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 2, 2008
Last modified:	February 9, 2010
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)