ID   A0A384LNB2_PLAKH        Unreviewed;       924 AA.
AC   A0A384LNB2; A0A1A7W3F3; B3LBK2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=PKNH_1404300 {ECO:0000313|EMBL:CAA9990642.1};
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851 {ECO:0000313|EMBL:CAA9990642.1, ECO:0000313|Proteomes:UP000031513};
RN   [1] {ECO:0000313|EMBL:CAA9990642.1, ECO:0000313|Proteomes:UP000031513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H {ECO:0000313|EMBL:CAA9990642.1,
RC   ECO:0000313|Proteomes:UP000031513};
RA   Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA   Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA   Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA   Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA   Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA   Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA   Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA   Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA   Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA   Newbold C.I., Barrell B.G., Berriman M.;
RT   "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT   with host range from monkey to man.";
RL   Nature 455:799-803(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC         ECO:0000256|RuleBase:RU000617};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; AM910996; CAA9990642.1; -; Genomic_DNA.
DR   RefSeq; XP_002261933.1; XM_002261897.1.
DR   AlphaFoldDB; A0A384LNB2; -.
DR   STRING; 5851.A0A384LNB2; -.
DR   GeneID; 7323359; -.
DR   KEGG; pkn:PKNH_1404300; -.
DR   VEuPathDB; PlasmoDB:PKNH_1404300; -.
DR   InParanoid; A0A384LNB2; -.
DR   OMA; CYATHSE; -.
DR   OrthoDB; 162082at2759; -.
DR   Proteomes; UP000031513; Chromosome 14.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07900; Adenylation_DNA_ligase_I_Euk; 1.
DR   CDD; cd07969; OBF_DNA_ligase_I; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR00574; dnl1; 1.
DR   PANTHER; PTHR45674:SF4; DNA LIGASE 1; 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..924
FT                   /note="DNA ligase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030070975"
FT   DOMAIN          655..791
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   REGION          85..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   924 AA;  105096 MW;  BD705ABD43EC8498 CRC64;
     MCIGSYANMK LLVLFLIARM LLCKVYSCMR REYSYIIPFM QKNKFYRRKT NFNVKVFTNF
     RDSASNRRSG FLKCLSFPKK TMEGKNEETD IKEESKVKEE GKESTKRKIA SDGNTKTKKA
     KAKSENDVKK GSLFNCTVKE DDKVSDLTSP KFNPVHFDVS NLYLSQKDKE KHKFKDSLLF
     TFLTNTFNQI EELKGSGTGS KKNVAIILSN VFRVLIYYSP NDLIPAVYIT LNKVAPDYLN
     VEAGVGEALI LKTMSEAYSR TESSIKKDLQ QIEDLGIIAE SCSCKMRTIF PLPRLTIQSV
     FNELKSIPNL SGSNSQQKKR EVIKKLLVSA KTSEAKYIVR FLQQRLRIGV NSATVLQALS
     YAFILTRPFI PEEIVQKGKL MNEQLLSVKG SGSGEEDDNV SDSTMENEMN KVNKKKGGML
     NVAKQTGESP SHVKKENEKE NQSVKDEFDM NALIESIKMR NEKISKPNLF YDIGKEGDTR
     LLPIFKELKK SYCEINNDSD IFECMEKSVK SALCELPNIE IIIQNLLNGD DMNTLSKKCT
     VKAGLPVQPM LAKPTKGIQE VLDRFNNVTF TCEYKYDGER AQIHYIDKDN IKIFSRNLET
     MTEKYPDVIQ IVRDQIISGA TECIIDSEVV AYDIENKKIL PFQVLTTRKR KDVDIENIKV
     KICLFPFDLI CCNGVPVIKE PLEIRRKLLY SLLKCKEGVL CYATHSEMNN VEDMDIFLQD
     AIENNCEGLM VKTLLDNASY EPSRRSLNWL KVKKDYIEGL SDSVDLVPIA GYYGKGKRSG
     VYGAFVLATY NSETENFQTV CKAGTGFSDE ILGSLYDTLS DKIIPSKKSY YEVSDKLNPD
     VWFDAHYVWE VKAADLSLSP VHTAAIGVYS DDKGIGLRFP RFLRLREDKN AEQATTSQQI
     VDLYEAQFTY NKNKNDFNEE SESE
//