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Protein

DNA ligase

Gene

PKH_140260

Organism
Plasmodium knowlesi (strain H)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PKH_140260Imported
OrganismiPlasmodium knowlesi (strain H)Imported
Taxonomic identifieri5851 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Plasmodium)
ProteomesiUP000000622: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PKH_140260.

Interactioni

Protein-protein interaction databases

STRINGi5850.PKH_140260.

Structurei

3D structure databases

ProteinModelPortaliB3LBK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiB3LBK2.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3LBK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIGSYANMK LLVLFLIARM LLCKVYSCMR REYSYIIPFM QKNKFYRRKT
60 70 80 90 100
NFNVKVFTNF RDSASNRRSG FLKCLSFPKK TMEGKNEETD IKEESKVKEE
110 120 130 140 150
GKESTKRKIA SDGNTKTKKA KAKSENDVKK GSLFNCTVKE DDKVSDLTSP
160 170 180 190 200
KFNPVHFDVS NLYLSQKDKE KHKFKDSLLF TFLTNTFNQI EELKGSGTGS
210 220 230 240 250
KKNVAIILSN VFRVLIYYSP NDLIPAVYIT LNKVAPDYLN VEAGVGEALI
260 270 280 290 300
LKTMSEAYSR TESSIKKDLQ QIEDLGIIAE SCSCKMRTIF PLPRLTIQSV
310 320 330 340 350
FNELKSIPNL SGSNSQQKKR EVIKKLLVSA KTSEAKYIVR FLQQRLRIGV
360 370 380 390 400
NSATVLQALS YAFILTRPFI PEEIVQKGKL MNEQLLSVKG SGSGEEDDNV
410 420 430 440 450
SDSTMENEMN KVNKKKGGML NVAKQTGESP SHVKKENEKE NQSVKDEFDM
460 470 480 490 500
NALIESIKMR NEKISKPNLF YDIGKEGDTR LLPIFKELKK SYCEINNDSD
510 520 530 540 550
IFECMEKSVK SALCELPNIE IIIQNLLNGD DMNTLSKKCT VKAGLPVQPM
560 570 580 590 600
LAKPTKGIQE VLDRFNNVTF TCEYKYDGER AQIHYIDKDN IKIFSRNLET
610 620 630 640 650
MTEKYPDVIQ IVRDQIISGA TECIIDSEVV AYDIENKKIL PFQVLTTRKR
660 670 680 690 700
KDVDIENIKV KICLFPFDLI CCNGVPVIKE PLEIRRKLLY SLLKCKEGVL
710 720 730 740 750
CYATHSEMNN VEDMDIFLQD AIENNCEGLM VKTLLDNASY EPSRRSLNWL
760 770 780 790 800
KVKKDYIEGL SDSVDLVPIA GYYGKGKRSG VYGAFVLATY NSETENFQTV
810 820 830 840 850
CKAGTGFSDE ILGSLYDTLS DKIIPSKKSY YEVSDKLNPD VWFDAHYVWE
860 870 880 890 900
VKAADLSLSP VHTAAIGVYS DDKGIGLRFP RFLRLREDKN AEQATTSQQI
910 920
VDLYEAQFTY NKNKNDFNEE SESE
Length:924
Mass (Da):105,096
Last modified:September 2, 2008 - v1
Checksum:iBD705ABD43EC8498
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM910996 Genomic DNA. Translation: CAQ41811.1.
RefSeqiXP_002261933.1. XM_002261897.1.

Genome annotation databases

EnsemblProtistsiPKH_140260; PKH_140260; PKH_140260.
GeneIDi7323359.
KEGGipkn:PKH_140260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM910996 Genomic DNA. Translation: CAQ41811.1.
RefSeqiXP_002261933.1. XM_002261897.1.

3D structure databases

ProteinModelPortaliB3LBK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5850.PKH_140260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPKH_140260; PKH_140260; PKH_140260.
GeneIDi7323359.
KEGGipkn:PKH_140260.

Organism-specific databases

EuPathDBiPlasmoDB:PKH_140260.

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiB3LBK2.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HImported.

Entry informationi

Entry nameiB3LBK2_PLAKH
AccessioniPrimary (citable) accession number: B3LBK2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 7, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.