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B3KY83

- B3KY83_HUMAN

UniProt

B3KY83 - B3KY83_HUMAN

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Protein
Submitted name: Retinoic acid receptor RXR-alpha
Gene
RXRA
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 9-cis retinoic acid receptor activity Source: Ensembl
  2. chromatin DNA binding Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl
  4. steroid hormone receptor activity Source: InterPro
  5. transcription regulatory region DNA binding Source: Ensembl
  6. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cardiac muscle cell proliferation Source: Ensembl
  2. embryo implantation Source: Ensembl
  3. in utero embryonic development Source: Ensembl
  4. maternal placenta development Source: Ensembl
  5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  8. secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl
  9. ventricular cardiac muscle cell differentiation Source: Ensembl
  10. ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Retinoic acid receptor RXR-alphaImported
Submitted name:
cDNA FLJ16020 fis, clone BRAMY2003287, highly similar to RETINOIC ACID RECEPTOR RXR-ALPHAImported
Gene namesi
Name:RXRAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:10477. RXRA.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Phylogenomic databases

HOVERGENiHBG005606.
KOiK08524.
OrthoDBiEOG72RMZ5.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3KY83-1 [UniParc]FASTAAdd to Basket

« Hide

MNPVSSSEDI KPPLGLNGVL KVPAHPSGNM ASFTKHICAI CGDRSSGKHY    50
GVYSCEGCKG FFKRTVRKDL TYTCRDNKDC LIDKRQRNRC QYCRYQKCLA 100
MGMKREAVQE ERQRGKDRNE NEVESTSSAN EDMPVERILE AELAVEPKTE 150
TYVEANMGLN PSSPNDPVTN ICQAADKQLF TLVEWAKRIP HFSELPLDDQ 200
VILLRAGWNE LLIASFSHRS IAVKDGILLA TGLHVHRNSA HSAGVGAIFD 250
RVLTELVSKM RDMQMDKTEL GCLRAIVLFN PDSKGLSNPA EVEALREKVY 300
ASLEAYCKHK YPEQPGRFAK LLLRLPALRS IGLKCLEHLF FFKLIGDTPI 350
DTFLMEMLEA PHQMT 365
Length:365
Mass (Da):41,060
Last modified:September 2, 2008 - v1
Checksum:i6F0D30787329986D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156789 Genomic DNA. No translation available.
AL354796 Genomic DNA. No translation available.
AL669970 Genomic DNA. No translation available.
AL683798 Genomic DNA. No translation available.
AK131192 mRNA. Translation: BAG54745.1.
RefSeqiNP_001278850.1. NM_001291921.1.
UniGeneiHs.590886.

Genome annotation databases

EnsembliENST00000540193; ENSP00000442123; ENSG00000186350.
GeneIDi6256.
KEGGihsa:6256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC156789 Genomic DNA. No translation available.
AL354796 Genomic DNA. No translation available.
AL669970 Genomic DNA. No translation available.
AL683798 Genomic DNA. No translation available.
AK131192 mRNA. Translation: BAG54745.1 .
RefSeqi NP_001278850.1. NM_001291921.1.
UniGenei Hs.590886.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000540193 ; ENSP00000442123 ; ENSG00000186350 .
GeneIDi 6256.
KEGGi hsa:6256.

Organism-specific databases

CTDi 6256.
HGNCi HGNC:10477. RXRA.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG005606.
KOi K08524.
OrthoDBi EOG72RMZ5.

Miscellaneous databases

NextBioi 35470706.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB3KY83_HUMAN
AccessioniPrimary (citable) accession number: B3KY83
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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