B3KY83 (B3KY83_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Retinoic acid receptor RXR-alpha Ensembl ENSP00000442123

Submitted name:
cDNA FLJ16020 fis, clone BRAMY2003287, highly similar to RETINOIC ACID RECEPTOR RXR-ALPHA EMBL BAG54745.1

Gene names

Name:

RXRA Ensembl ENSP00000442123

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAG54745.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS000536 RuleBase RU004334
Cellular component	Nucleus SAAS SAAS000536 RuleBase RU004334
Domain	Zinc-finger SAAS SAAS000536 RuleBase RU004334
Ligand	DNA-binding SAAS SAAS000536 RuleBase RU004334 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL BAG54745.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle cell proliferation Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara maternal placenta development Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of branching involved in prostate gland morphogenesis Inferred from electronic annotation. Source: Compara secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Inferred from electronic annotation. Source: Compara ventricular cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara ventricular cardiac muscle tissue morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	9-cis retinoic acid receptor activity Inferred from electronic annotation. Source: Compara chromatin DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: Compara steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3KY83 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 6F0D30787329986D	FASTA	365	41,060
	10 20 30 40 50 60 MNPVSSSEDI KPPLGLNGVL KVPAHPSGNM ASFTKHICAI CGDRSSGKHY GVYSCEGCKG 70 80 90 100 110 120 FFKRTVRKDL TYTCRDNKDC LIDKRQRNRC QYCRYQKCLA MGMKREAVQE ERQRGKDRNE 130 140 150 160 170 180 NEVESTSSAN EDMPVERILE AELAVEPKTE TYVEANMGLN PSSPNDPVTN ICQAADKQLF 190 200 210 220 230 240 TLVEWAKRIP HFSELPLDDQ VILLRAGWNE LLIASFSHRS IAVKDGILLA TGLHVHRNSA 250 260 270 280 290 300 HSAGVGAIFD RVLTELVSKM RDMQMDKTEL GCLRAIVLFN PDSKGLSNPA EVEALREKVY 310 320 330 340 350 360 ASLEAYCKHK YPEQPGRFAK LLLRLPALRS IGLKCLEHLF FFKLIGDTPI DTFLMEMLEA PHQMT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project." Tashiro H., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Sugiyama T., Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K. , Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Amygdala EMBL BAG54745.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC156789 Genomic DNA. No translation available. AL354796 Genomic DNA. No translation available. AL669970 Genomic DNA. No translation available. AL683798 Genomic DNA. No translation available. AK131192 mRNA. Translation: BAG54745.1.
IPI	IPI01011260.
UniGene	Hs.590886.
3D structure databases
SMR	B3KY83. Positions 35-362.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000540193; ENSP00000442123; ENSG00000186350.
Organism-specific databases
HGNC	HGNC:10477. RXRA.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG005606.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR021780. Nuc_recep-AF1. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR000003. Retinoid-X_rcpt/HNF4. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF11825. Nuc_recep-AF1. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00545. RETINOIDXR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35470706.

Entry information

Entry name

B3KY83_HUMAN

Accession

Primary (citable) accession number: B3KY83

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	May 29, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.