B3KY27 (B3KY27_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Branched-chain-amino-acid aminotransferase RuleBase RU004517
EC=2.6.1.42 RuleBase RU004517

Gene names

Name:

BCAT1 Ensembl ENSP00000339805

Organism

Homo sapiens (Human) EMBL BAG54689.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. RuleBase RU004517 2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid. RuleBase RU004517 L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. RuleBase RU004517
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU004516
Sequence similarities	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. RuleBase RU004106

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis RuleBase RU004518
Ligand	Pyridoxal phosphate RuleBase RU004516
Molecular function	Aminotransferase RuleBase RU004517 EMBL BAG54689.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-isoleucine transaminase activity Inferred from electronic annotation. Source: EC L-leucine transaminase activity Inferred from electronic annotation. Source: EC L-valine transaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	161	1	N6-(pyridoxal phosphate)lysine By similarity PIRSR PIRSR006468-1

Sequences

	Sequence		Length	Mass (Da)
	B3KY27 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: FDC0B4CC0356E91D	FASTA	325	36,298
	10 20 30 40 50 60 MKAKDLIVTP ATILKEKPDP NNLVFGTVFT DHMLTVEWSS EFGWEKPHIK PLQNLSLHPG 70 80 90 100 110 120 SSALHYAVEV FDKEELLECI QQLVKLDQEW VPYSTSASLY IRPTFIGTEP SLGVKKPTKA 130 140 150 160 170 180 LLFVLLSPVG PYFSSGTFNP VSLWANPKYV RAWKGGTGDC KMGGNYGSSL FAQCEAVDNG 190 200 210 220 230 240 CQQVLWLYGE DHQITEVGTM NLFLYWINED GEEELATPPL DGIILPGVTR RCILDLAHQW 250 260 270 280 290 300 GEFKVSERYL TMDDLTTALE GNRVREMFGS GTACVVCPVS DILYKGETIH IPTMENGPKL 310 320 ASRILSKLTD IQYGREESDW TIVLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project." Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., Arita M., Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., Otsuki T., Sato H., Ota T., Wakamatsu A., Ishii S., Yamamoto J., Isono Y. , Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Trachea EMBL BAG54689.1.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC023796 Genomic DNA. No translation available. AC026310 Genomic DNA. No translation available. AC092867 Genomic DNA. No translation available. AK128527 mRNA. Translation: BAG54689.1.
IPI	IPI00940330.
RefSeq	NP_001171563.1. NM_001178092.1.
UniGene	Hs.438993.
3D structure databases
ProteinModelPortal	B3KY27.
SMR	B3KY27. Positions 2-324.
ModBase	Search...
Protein-protein interaction databases
STRING	B3KY27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342945; ENSP00000339805; ENSG00000060982.
GeneID	586.
KEGG	hsa:586.
Organism-specific databases
CTD	586.
HGNC	HGNC:976. BCAT1.
PharmGKB	PA25288.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG050678.
Gene expression databases
Bgee	B3KY27.
Family and domain databases
InterPro	IPR001544. Aminotrans_IV. IPR018300. Aminotrans_IV_CS. IPR005786. B_amino_transII. [Graphical view]
KO	K00826.
PANTHER	PTHR11825. Aminotrans_IV. 1 hit. PTHR11825:SF2. B_amino_transII. 1 hit.
Pfam	PF01063. Aminotran_4. 1 hit. [Graphical view]
PIRSF	PIRSF006468. BCAT1. 1 hit.
SUPFAM	SSF56752. Aminotrans_IV. 1 hit.
PROSITE	PS00770. AA_TRANSFER_CLASS_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B3KY27_HUMAN

Accession

Primary (citable) accession number: B3KY27

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.