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Protein
Submitted name:

cDNA FLJ46571 fis, clone THYMU3041428, highly similar to Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotationImported, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ46571 fis, clone THYMU3041428, highly similar to Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934941.

PTM / Processingi

Proteomic databases

PaxDbiB3KY11.

Expressioni

Gene expression databases

BgeeiB3KY11.
GenevisibleiB3KY11. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310723.

Structurei

3D structure databases

ProteinModelPortaliB3KY11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini371 – 39929Q_MOTIFInterPro annotationAdd
BLAST
Domaini402 – 607206Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini631 – 779149Helicase C-terminalInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 18138Sequence analysisAdd
BLAST
Coiled coili303 – 33028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0333. Eukaryota.
ENOG410XNVG. LUCA.
HOGENOMiHOG000268796.
HOVERGENiHBG102054.
KOiK12858.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3KY11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGELADKKD RDASPSKEER KRSRTPDRER DRDRDRKSSP SKDRKRHRSR
60 70 80 90 100
DRRRGGSRSR SRSRSKSAER ERRHKERERD KERDRNKKDR DRGKDFKSRK
110 120 130 140 150
DRDSKKDEED EHGDKKPKAQ PLSLEELLAK KKAEEEAEAK PKFLSKAERE
160 170 180 190 200
AEALKRRQQE VEERQRMLEE ERKKRKQFQD LGRKMLEDPQ ERERRERRER
210 220 230 240 250
MERETNGNED EEGRQKIREE KDKSKELHAI KERYLGGIKK RRRTRHLNDR
260 270 280 290 300
KFVFEWDASE DTSIDYNPLY KERHQVQLLG RGFIAGIDLK QQKREQSRFY
310 320 330 340 350
GDLMEKRRTL EEKEQEEARL RKLRKKEAKQ RWDDRHWSQK KLDEMTDRDW
360 370 380 390 400
RIFREDYSIT TKGGKIPNPI RSWKDSSLPP HILEVIDKCG YKEPTPIQRQ
410 420 430 440 450
AIPIGLQNRD IIGVAETGSG KTAAFLIPLL VWITTLPKID RIEESDQGPY
460 470 480 490 500
AIILAPTREL AQQIEEETIK FGKPLGIRTV AVIGGISRED QGFRLRMGCE
510 520 530 540 550
IVIATPGRLI DVLENRYLVL SRCTYVVLDE ADRMIDMGFE PDVQKILEHM
560 570 580 590 600
PVSNQKPDTD EAEDPEKMLA NFESGKHKYR QTVMFTATMP PAVERLARSY
610 620 630 640 650
LRRPAVVYIG SAGKPHERVE QKVFLMSESE KRKKLLAILE QGFDPPIIIF
660 670 680 690 700
VNQKKGCDVL AKSLEKMGYN ACTLHGGKGQ EQREFALSNL KAGAKDILVA
710 720 730 740 750
TDVAGRGIDI QDVSMVVNYD MAKNIEDYIH RIGRTGRAGK SGVAITFLTK
760 770 780 790 800
EDSAVFYELK QAILESPVSS CPPELANHPD AQHKPGTILT KKRREETIFA
Length:800
Mass (Da):93,234
Last modified:September 2, 2008 - v1
Checksum:iC071691EAB2A03D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128428 mRNA. Translation: BAG54673.1.
RefSeqiNP_004809.2. NM_004818.2.
UniGeneiHs.130098.

Genome annotation databases

GeneIDi9416.
KEGGihsa:9416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128428 mRNA. Translation: BAG54673.1.
RefSeqiNP_004809.2. NM_004818.2.
UniGeneiHs.130098.

3D structure databases

ProteinModelPortaliB3KY11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310723.

Proteomic databases

PaxDbiB3KY11.

Protocols and materials databases

DNASUi9416.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9416.
KEGGihsa:9416.

Organism-specific databases

CTDi9416.
PharmGKBiPA134934941.

Phylogenomic databases

eggNOGiKOG0333. Eukaryota.
ENOG410XNVG. LUCA.
HOGENOMiHOG000268796.
HOVERGENiHBG102054.
KOiK12858.

Miscellaneous databases

GenomeRNAii9416.

Gene expression databases

BgeeiB3KY11.
GenevisibleiB3KY11. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThymusImported.

Entry informationi

Entry nameiB3KY11_HUMAN
AccessioniPrimary (citable) accession number: B3KY11
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.