B3KXY9 (B3KXY9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ46359 fis, clone TESTI4049786, highly similar to Hexokinase-1 (EC 2.7.1.1) EMBL BAG54651.1
Organism	Homo sapiens (Human) EMBL BAG54651.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	952 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the hexokinase family. RuleBase RU004510

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS022672 RuleBase RU004049
Ligand	ATP-binding SAAS SAAS022672 RuleBase RU004049 Nucleotide-binding
Molecular function	Kinase SAAS SAAS022672 RuleBase RU004049 EMBL BAG54651.1 Transferase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3KXY9 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: A94B1EA9F55547E7	FASTA	952	106,251
	10 20 30 40 50 60 MGQICQRESR QGLAMLPRLF LNPWRQVILL PQPPKVLGLQ ATAAEKPKLH LLAESEIDKY 70 80 90 100 110 120 LYAMRLSDET LIDIMTRFRK EMKNGLSRDF NPTATVKMLP TFVRPIPDGS EKGDFIALDL 130 140 150 160 170 180 GGSSFRILRV QVNHEKNQNV HMESEVYDTP ENIVHGSGSQ LFDHVAECLG DFMEKRKIKD 190 200 210 220 230 240 KKLPVGFTFS FPCQQSKIDE AILITWTKRF KASGVEGADV VKLLNKAIKK RGDYDANIVA 250 260 270 280 290 300 VVNDTVGTMM TCGYDDQHCE VGLIIGTGTN ACYMEELRHI DLVEGDEGRM CINTEWGAFG 310 320 330 340 350 360 DDGSLEDIRT EFDREIDRGS LNPGKQLFEK MVSGMYLGEL VRLILVKMAK EGLLFEGRIT 370 380 390 400 410 420 PELLTRGKFN TSDVSAIEKN KEGLHNAKEI LTRLGVEPSD DDCVSVQHVC TIVSFRSANL 430 440 450 460 470 480 VAATLGAILN RLRDNKGTPR LRTTVGVDGS LYKTHPQYSR RFHKTLRRLV PDSDVRFLLS 490 500 510 520 530 540 ESGSGKGAAM VTAVAYRLAE QHRQIEETLA HFHLTKDMLL EVKKRMRAEM ELGLRKQTHN 550 560 570 580 590 600 NAVVKMLPSF VRRTPDGTEN GDFLALDLGG TNFRVLLVKI RSGKKRTVEM HNKIYAIPIE 610 620 630 640 650 660 IMQGTGEELF DHIVSCISDF LDYMGIKGPR MPLGFTFSFP CQQTSLDAGI LITWTKGFKA 670 680 690 700 710 720 TDCVGHDVVT LLRDAIKRRE EFDLDVVAVV NDTVGTMMTC AYGEPTCEVG LIVGTGSNAC 730 740 750 760 770 780 YMEEMKNVEM VEGDQGQMCI NMEWGAFGDN GCLDDIRTHY DRLVDEYSLN AGKQRYEKMI 790 800 810 820 830 840 SGMYLGEIVR NILIDFTKKG FLFRGQISET LKTRGIFETK FLSQIESDRL ALLQVRAILQ 850 860 870 880 890 900 QLGLNSTCDD SILVKTVCGV VSRRAAQLCG AGMAAVVDKI RENRGLDRLN VTVGVDGTLY 910 920 930 940 950 KLHPHFSRIM HQTVKELSPK CNVSFLLSED GSGKGAALIT AVGVRLRTEA SS

References

[1]

"NEDO human cDNA sequencing project." Ninomiya K., Wagatsuma M., Kanda K., Kondo H., Yokoi T., Kodaira H., Furuya T., Takahashi M., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Sugiyama T., Irie R. , Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Murakawa K., Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL BAG54651.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK128226 mRNA. Translation: BAG54651.1.
IPI	IPI00903226.
RefSeq	NP_000179.2. NM_000188.2. NP_277031.1. NM_033496.2. NP_277032.1. NM_033497.2. NP_277033.1. NM_033498.2. NP_277035.2. NM_033500.2.
UniGene	Hs.370365.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B3KXY9.
Proteomic databases
PRIDE	B3KXY9.
Protocols and materials databases
DNASU	3098.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3098.
KEGG	hsa:3098.
Organism-specific databases
CTD	3098.
PharmGKB	PA29300.
Phylogenomic databases
HOGENOM	HOG000162671.
HOVERGEN	HBG005020.
KO	K00844.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 2 hits. PF03727. Hexokinase_2. 2 hits. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3098.
NextBio	12293.

Entry information

Entry name

B3KXY9_HUMAN

Accession

Primary (citable) accession number: B3KXY9

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	October 3, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.