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Protein

Structural maintenance of chromosomes protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiB3KXX5.
PRIDEiB3KXX5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341382.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini588 – 703116SMC_hingeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili302 – 35049Sequence analysisAdd
BLAST
Coiled coili372 – 40635Sequence analysisAdd
BLAST
Coiled coili414 – 45946Sequence analysisAdd
BLAST
Coiled coili516 – 55035Sequence analysisAdd
BLAST
Coiled coili744 – 82077Sequence analysisAdd
BLAST
Coiled coili874 – 985112Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0996. Eukaryota.
COG1196. LUCA.
HOGENOMiHOG000184777.
HOVERGENiHBG106696.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

B3KXX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKGTQPST ARRREEGPPP PSPDGASSDA EPEPPSGRTE SPATAAAMTN
60 70 80 90 100
EAGAPRLMIT HIVNQNFKSY AGEKILGPFH KRFSCIIGPN GSGKSNVIDS
110 120 130 140 150
MLFVFGYRAQ KIRSKKLSVL IHNSDEHKDI QSCTVEVHFQ KIIDKEGDDY
160 170 180 190 200
EVIPNSNFYV SRTACRDNTS VYHISGKKKT FKDVGNLLRS HGIDLDHNRF
210 220 230 240 250
LILQGEVEQI AMMKPKGQTE HDEGMLEYLE DIIGCGRLNE PIKVLCRRVE
260 270 280 290 300
ILNEHRGEKL NRVKMVEKEK DALEGEKNIA IEFLTLENEI FRKKNHVCQY
310 320 330 340 350
YIYELQKRIA EMETQKEKIH EDTKEINEKS NILSNEMKAK NKDVKDTEKK
360 370 380 390 400
LNKITKFIEE NKEKFTQLDL EDVQVREKLK HATSKAKKLE KQLQKDKEKV
410 420 430 440 450
EEFKSIPAKS NNIINETTTR NNALEKEKEK EEKKLKEVMD SLKQETQGLQ
460 470 480 490 500
KEKESREKEL MGFSKSVNEA RSKMDVAQSE LDIYLSRHNT AVSQLTKAKE
510 520 530 540 550
ALIAASETLK ERKAAIRDIE GKLPQTEQEL KEKEKELQKL TQEETNFKSL
560 570 580 590 600
VHDLFQKVEE AKSSLAMNRS RGKVLDAIIQ EKKSGRIPGI YGRLGDLGAI
610 620 630 640 650
DEKYDVAISS CCHALDYIVV DSIDIAQECV NFLKRQNIGV ATFIGLDKMA
660 670 680 690 700
VWAKKMTEIQ TPENTPRLFD LVKVKDEKIR QAFYFALRDT LVADNLDQAT
710 720 730 740 750
RVAYQKDRRW RVVTLQGQII EQSGTMTGGG SKVMKGRMGS SLVIEISEEE
760 770 780 790 800
VNKMESQLQN DSKKAMQIQE QKVQLEERVV KLRHSEREMR NTLEKFTASI
810 820 830 840 850
QRLIEQEEYL NVQVKELEAN VLATAPDKKK QKLLEENVSA FKTEYDAVAE
860 870 880 890 900
KAGKVEAEVK RLHNTIVEIN NHKLKAQQDK LDKINKQLDE CASAITKAQV
910 920 930 940 950
AIKTADRDLQ KAQDSVLRTE KEIKDTEKEV DDLTAELKSL EDKAAEVVKN
960 970 980 990 1000
TNAAEESLPE IQKEHRNLLQ ELKVIQENEH ALQKDALSIK LKLEQIDGHI
1010 1020 1030 1040 1050
AEHNSKIKYW HKEISKISLH PIEDNPIEEI SVLSPEDLEA IKNPDSITNQ
1060 1070 1080 1090 1100
IALLEARCHE MKPNLGAIAE YKKKEELYLQ RVAELDKITY ERDSFRQAYE
1110 1120 1130 1140 1150
DLRKQRLNEF MAGFYIITNK LKENYQMLTL GGDAELELVD SLDPFSEGIM
1160 1170 1180 1190 1200
FSVRPPKKSW KKIFNLSGGE KTLSSLALVF ALHHYKPTPL YFMDEIDAAL
1210 1220 1230 1240 1250
DFKNVSIVAF YIYEQTKNAQ FIIISLRNNM FEISDRLIGI YKTYNITKSV
1260
AVNPKEIASK GLC
Length:1,263
Mass (Da):144,456
Last modified:September 2, 2008 - v1
Checksum:iA1669A9A30E00866
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128143 mRNA. Translation: BAG54637.1.
RefSeqiNP_001275682.1. NM_001288753.1.
UniGeneiHs.58992.

Genome annotation databases

GeneIDi10051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128143 mRNA. Translation: BAG54637.1.
RefSeqiNP_001275682.1. NM_001288753.1.
UniGeneiHs.58992.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341382.

Proteomic databases

PaxDbiB3KXX5.
PRIDEiB3KXX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10051.

Organism-specific databases

CTDi10051.

Phylogenomic databases

eggNOGiKOG0996. Eukaryota.
COG1196. LUCA.
HOGENOMiHOG000184777.
HOVERGENiHBG106696.

Miscellaneous databases

GenomeRNAii10051.
NextBioi35470652.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiB3KXX5_HUMAN
AccessioniPrimary (citable) accession number: B3KXX5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 16, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.