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B3KXD7

- B3KXD7_HUMAN

UniProt

B3KXD7 - B3KXD7_HUMAN

Protein
Submitted name:

cDNA FLJ45258 fis, clone BRHIP2019884, highly similar to RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. aging Source: Ensembl
    2. anagen Source: Ensembl
    3. apoptotic mitochondrial changes Source: Ensembl
    4. cell projection organization Source: Ensembl
    5. cellular response to epidermal growth factor stimulus Source: Ensembl
    6. cellular response to hypoxia Source: Ensembl
    7. cellular response to insulin stimulus Source: Ensembl
    8. cellular response to mechanical stimulus Source: Ensembl
    9. execution phase of apoptosis Source: Ensembl
    10. germ cell development Source: Ensembl
    11. glucose homeostasis Source: Ensembl
    12. glucose metabolic process Source: Ensembl
    13. glucose transport Source: Ensembl
    14. glycogen biosynthetic process Source: Ensembl
    15. glycogen cell differentiation involved in embryonic placenta development Source: Ensembl
    16. hyaluronan metabolic process Source: Ensembl
    17. inflammatory response Source: Ensembl
    18. labyrinthine layer blood vessel development Source: Ensembl
    19. maternal placenta development Source: Ensembl
    20. negative regulation of apoptotic process Source: Ensembl
    21. negative regulation of cell size Source: Ensembl
    22. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    23. negative regulation of JNK cascade Source: Ensembl
    24. negative regulation of protein kinase activity Source: Ensembl
    25. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
    26. osteoblast differentiation Source: Ensembl
    27. peptidyl-serine phosphorylation Source: Ensembl
    28. peripheral nervous system myelin maintenance Source: Ensembl
    29. positive regulation of apoptotic process Source: Ensembl
    30. positive regulation of cell growth Source: Ensembl
    31. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    32. positive regulation of sodium ion transport Source: Ensembl
    33. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    34. positive regulation of vasoconstriction Source: Ensembl
    35. protein catabolic process Source: Ensembl
    36. protein kinase B signaling Source: Ensembl
    37. protein ubiquitination Source: Ensembl
    38. regulation of cell migration Source: Ensembl
    39. regulation of neuron projection development Source: Ensembl
    40. regulation of protein localization Source: Ensembl
    41. response to food Source: Ensembl
    42. striated muscle cell differentiation Source: Ensembl
    43. translation Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiB3KXD7.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ45258 fis, clone BRHIP2019884, highly similar to RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: Ensembl
    3. spindle Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiB3KXD7.
    BgeeiB3KXD7.

    Interactioni

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG091721.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view]
    SMARTiSM00133. S_TK_X. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3KXD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDKDGHIKI TDFGLCKEGI KDGATMKTFC GTPEYLAPEV LEDNDYGRAV    50
    DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL 100
    SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT 150
    SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA 200
    Length:200
    Mass (Da):22,904
    Last modified:September 2, 2008 - v1
    Checksum:iA84C06AC29519763
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127193 mRNA. Translation: BAG54449.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127193 mRNA. Translation: BAG54449.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi B3KXD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG091721.

    Enzyme and pathway databases

    SignaLinki B3KXD7.

    Miscellaneous databases

    NextBioi 35470576.

    Gene expression databases

    ArrayExpressi B3KXD7.
    Bgeei B3KXD7.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00133. S_TK_X. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: HippocampusImported.

    Entry informationi

    Entry nameiB3KXD7_HUMAN
    AccessioniPrimary (citable) accession number: B3KXD7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.