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Protein
Submitted name:

cDNA FLJ45258 fis, clone BRHIP2019884, highly similar to RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. aging Source: Ensembl
  2. apoptotic mitochondrial changes Source: Ensembl
  3. cell projection organization Source: Ensembl
  4. cellular response to epidermal growth factor stimulus Source: Ensembl
  5. cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
  6. cellular response to hypoxia Source: Ensembl
  7. cellular response to insulin stimulus Source: Ensembl
  8. cellular response to mechanical stimulus Source: Ensembl
  9. cellular response to organic cyclic compound Source: Ensembl
  10. execution phase of apoptosis Source: Ensembl
  11. germ cell development Source: Ensembl
  12. glucose homeostasis Source: Ensembl
  13. glucose metabolic process Source: Ensembl
  14. glucose transport Source: Ensembl
  15. glycogen biosynthetic process Source: Ensembl
  16. glycogen cell differentiation involved in embryonic placenta development Source: Ensembl
  17. hyaluronan metabolic process Source: Ensembl
  18. inflammatory response Source: Ensembl
  19. labyrinthine layer blood vessel development Source: Ensembl
  20. maternal placenta development Source: Ensembl
  21. negative regulation of cell size Source: Ensembl
  22. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  23. negative regulation of JNK cascade Source: Ensembl
  24. negative regulation of protein kinase activity Source: Ensembl
  25. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
  26. osteoblast differentiation Source: Ensembl
  27. peptidyl-serine phosphorylation Source: Ensembl
  28. peripheral nervous system myelin maintenance Source: Ensembl
  29. positive regulation of apoptotic process Source: Ensembl
  30. positive regulation of cell growth Source: Ensembl
  31. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  32. positive regulation of sodium ion transport Source: Ensembl
  33. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  34. positive regulation of vasoconstriction Source: Ensembl
  35. protein catabolic process Source: Ensembl
  36. protein kinase B signaling Source: Ensembl
  37. protein ubiquitination Source: Ensembl
  38. regulation of cell migration Source: Ensembl
  39. regulation of myelination Source: Ensembl
  40. regulation of neuron projection development Source: Ensembl
  41. regulation of protein localization Source: Ensembl
  42. response to food Source: Ensembl
  43. striated muscle cell differentiation Source: Ensembl
  44. translation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB3KXD7.

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ45258 fis, clone BRHIP2019884, highly similar to RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. ciliary basal body Source: Ensembl
  3. cytosol Source: Ensembl
  4. mitochondrion Source: Ensembl
  5. nucleus Source: Ensembl
  6. spindle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiB3KXD7.
ExpressionAtlasiB3KXD7. baseline and differential.

Interactioni

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG091721.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3KXD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDKDGHIKI TDFGLCKEGI KDGATMKTFC GTPEYLAPEV LEDNDYGRAV
60 70 80 90 100
DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL
110 120 130 140 150
SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT
160 170 180 190 200
SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA
Length:200
Mass (Da):22,904
Last modified:September 1, 2008 - v1
Checksum:iA84C06AC29519763
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127193 mRNA. Translation: BAG54449.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127193 mRNA. Translation: BAG54449.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiB3KXD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG091721.

Enzyme and pathway databases

SignaLinkiB3KXD7.

Miscellaneous databases

NextBioi35470576.

Gene expression databases

BgeeiB3KXD7.
ExpressionAtlasiB3KXD7. baseline and differential.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiB3KXD7_HUMAN
AccessioniPrimary (citable) accession number: B3KXD7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2008
Last sequence update: September 1, 2008
Last modified: March 3, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.