B3KWR9 (B3KWR9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Toll-like receptor PIRNR PIRNR037595
Organism	Homo sapiens (Human) EMBL BAG54231.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	784 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595 Contains 1 TIR domain. SAAS SAAS000483

Ontologies

Keywords
Biological process	Immunity Inflammatory response PIRNR PIRNR037595 Innate immunity PIRNR PIRNR037595
Cellular component	Membrane
Domain	Leucine-rich repeat SAAS SAAS000483 Repeat SAAS SAAS000483 Transmembrane Transmembrane helix SAAS SAAS000483
Molecular function	Receptor PIRNR PIRNR037595 EMBL BAG54231.1
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of inflammatory response Inferred from electronic annotation. Source: InterPro regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro response to molecule of bacterial origin Inferred from electronic annotation. Source: InterPro toll-like receptor 2 signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3KWR9 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 10CBBD878AE70CBB	FASTA	784	89,826
	10 20 30 40 50 60 MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSTPSGL TEAVKSLDLS 70 80 90 100 110 120 NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG SLEHLDLSYN YLSNLSSSWF 130 140 150 160 170 180 KPLSSLTFLN LLGNPYKTLG ETSLFSHLTK LQILRVGNMD TFTKIQRKDF AGLTFLEELE 190 200 210 220 230 240 IDASDLQSYE PKSLKSIQNV SHLILHMKQH ILLLEIFVDV TSSVECLELR DTDLDTFHFS 250 260 270 280 290 300 ELSTGETNSL IKKFTFRNVK ITDESLFQVM KLLNQISGLL ELEFDDCTLN GVGNFRASDN 310 320 330 340 350 360 DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERVKR ITVENSKVFL VPCLLSQHLK 370 380 390 400 410 420 SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA SLEKTGETLL TLKNLTNIDI 430 440 450 460 470 480 SKNSFHSMPE TCQWPEKMKY LNLSSTRIHS VTGCIPKTLE ILDVSNNNLN LFSLNLPQLK 490 500 510 520 530 540 ELYISRNKLM TLPDASLLPM LLVLKISRNA ITTFSKEQLD SFHTLKTLEA GGNNFICSCE 550 560 570 580 590 600 FLSFTQEQQA LAKVLIDWPA NYLCDSPSHV RGQQVQDVRL SVSECHRTAL VSGMCCALFL 610 620 630 640 650 660 LILLTGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPSRNIC YDAFVSYSER DAYWVENLMV 670 680 690 700 710 720 QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV FVLSENFVKS EWCKYELDFS 730 740 750 760 770 780 HFRLFDENND AAILILLEPI EKKAIPQRFC KLRKIMNTKT YLEWPMDEAQ REGFWVNLRA AIKS

References

[1]

"NEDO human cDNA sequencing project." Ota T., Nakagawa S., Senoh A., Mizuguchi H., Inagaki H., Sugiyama T., Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H. , Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Synovial membrane tissue EMBL BAG54231.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK125659 mRNA. Translation: BAG54231.1.
IPI	IPI00019006.
RefSeq	NP_003255.2. NM_003264.3.
UniGene	Hs.519033.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	B3KWR9.
Protocols and materials databases
DNASU	7097.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7097.
KEGG	hsa:7097.
Organism-specific databases
CTD	7097.
PharmGKB	PA36550.
Phylogenomic databases
HOVERGEN	HBG108574.
KO	K10159.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. IPR027185. TLR2. IPR017241. Toll-like_receptor. [Graphical view]
PANTHER	PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
PIRSF	PIRSF037595. Toll-like_receptor. 1 hit.
SMART	SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 11 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7097.
NextBio	27765.

Entry information

Entry name

B3KWR9_HUMAN

Accession

Primary (citable) accession number: B3KWR9

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	May 29, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.