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Protein
Submitted name:

Histidine--tRNA ligase, cytoplasmic

Gene

HARS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseImported, Ligase

Names & Taxonomyi

Protein namesi
Submitted name:
Histidine--tRNA ligase, cytoplasmicImported
Submitted name:
Histidyl-tRNA synthetase, isoform CRA_aImported
Submitted name:
cDNA FLJ42841 fis, clone BRCOC2003213, highly similar to Histidyl-tRNA synthetase (EC 6.1.1.21)Imported
Gene namesi
Name:HARSImported
ORF Names:hCG_1782886Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:4816. HARS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170445.

PTM / Processingi

Proteomic databases

MaxQBiB3KWE1.
PeptideAtlasiB3KWE1.
PRIDEiB3KWE1.

Expressioni

Gene expression databases

BgeeiENSG00000170445.
ExpressionAtlasiB3KWE1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000425634.

Structurei

3D structure databases

ProteinModelPortaliB3KWE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 324AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 348Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1936. Eukaryota.
COG0124. LUCA.
GeneTreeiENSGT00390000005922.
HOGENOMiHOG000018075.
HOVERGENiHBG002731.

Family and domain databases

CDDicd00859. HisRS_anticodon. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR033656. HisRS_anticodon.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3KWE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVREKVFDV IIRCFKRHGA EVIDTPVFEL KETLMGKYGE DSKLIYDLKD
60 70 80 90 100
QGGELLSLRY DLTVPFARYL AMNKLTNIKR YHIAKVYRRD NPAMTRGRYR
110 120 130 140 150
EFYQCDFDIA GNFDPMIPDA ECLKIMCEIL SSLQIGDFLV KVNDRRILDG
160 170 180 190 200
MFAICGVSDS KFRTICSSVD KLDKVSWEEV KNEMVGEKGL APEVADRIGD
210 220 230 240 250
YVQQHGGVSL VEQLLQDPKL SQNKQALEGL GDLKLLFEYL TLFGIDDKIS
260 270 280 290 300
FDLSLARGLD YYTGVIYEAV LLQTPAQAGE EPLGVGSVAA GGRYDGLVGM
310 320 330 340 350
FDPKGRKVPC VGLSIGVERI FSIVEQRLEA LEEKIRTTET QVLVASAQKK
360 370 380 390 400
LLEERLKLVS ELWDAGIKAE LLYKKNPKLL NQLQYCEEAG IPLVAIIGEQ
410 420 430 440
ELKDGVIKLR SVTSREEVDV RREDLVEEIK RRTGQPLCIC
Length:440
Mass (Da):49,623
Last modified:September 2, 2008 - v1
Checksum:iB98094B7E3F33779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116353 Genomic DNA. No translation available.
AK124831 mRNA. Translation: BAG54103.1.
CH471062 Genomic DNA. Translation: EAW62021.1.
UniGeneiHs.528050.

Genome annotation databases

EnsembliENST00000504366; ENSP00000430063; ENSG00000170445.
UCSCiuc003lgu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116353 Genomic DNA. No translation available.
AK124831 mRNA. Translation: BAG54103.1.
CH471062 Genomic DNA. Translation: EAW62021.1.
UniGeneiHs.528050.

3D structure databases

ProteinModelPortaliB3KWE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000425634.

Proteomic databases

MaxQBiB3KWE1.
PeptideAtlasiB3KWE1.
PRIDEiB3KWE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504366; ENSP00000430063; ENSG00000170445.
UCSCiuc003lgu.5. human.

Organism-specific databases

HGNCiHGNC:4816. HARS.
OpenTargetsiENSG00000170445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1936. Eukaryota.
COG0124. LUCA.
GeneTreeiENSGT00390000005922.
HOGENOMiHOG000018075.
HOVERGENiHBG002731.

Miscellaneous databases

ChiTaRSiHARS. human.

Gene expression databases

BgeeiENSG00000170445.
ExpressionAtlasiB3KWE1. baseline and differential.

Family and domain databases

CDDicd00859. HisRS_anticodon. 1 hit.
Gene3Di3.40.50.800. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR033656. HisRS_anticodon.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3KWE1_HUMAN
AccessioniPrimary (citable) accession number: B3KWE1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.