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Protein
Submitted name:

Adenylate cyclase type 5

Gene

ADCY5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandNucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase type 5Imported
Submitted name:
cDNA FLJ42701 fis, clone BRAMY3004919, highly similar to Adenylate cyclase type 5 (EC 4.6.1.1)Imported
Gene namesi
Name:ADCY5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000173175.14
HGNCiHGNC:236 ADCY5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei394 – 415HelicalSequence analysisAdd BLAST22
Transmembranei421 – 446HelicalSequence analysisAdd BLAST26
Transmembranei467 – 488HelicalSequence analysisAdd BLAST22
Transmembranei542 – 560HelicalSequence analysisAdd BLAST19
Transmembranei567 – 588HelicalSequence analysisAdd BLAST22
Transmembranei642 – 661HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173175

PTM / Processingi

Proteomic databases

MaxQBiB3KWA8
PeptideAtlasiB3KWA8

Expressioni

Gene expression databases

BgeeiENSG00000173175

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 229Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini729 – 868Guanylate cyclaseInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili680 – 700Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3619 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000119042
HOGENOMiHOG000006941
HOVERGENiHBG050458

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR032628 AC_N
IPR030672 Adcy
IPR009398 Adcy_conserved_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF16214 AC_N, 1 hit
PF06327 DUF1053, 1 hit
PF00211 Guanylate_cyc, 2 hits
PIRSFiPIRSF039050 Ade_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequencei

Sequence statusi: Complete.

B3KWA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSRFRTQL ELVSNVLIFS CTNIVGVCTH YPAEVSQRQA FQETRECIQA
60 70 80 90 100
RLHSQRENQQ QERLLLSVLP RHVAMEMKAD INAKQEDMMF HKIYIQKHDN
110 120 130 140 150
VSILFADIEG FTSLASQCTA QELVMTLNEL FARFDKLAAE NHCLRIKILG
160 170 180 190 200
DCYYCVSGLP EARADHAHCC VEMGMDMIEA ISLVREVTGV NVNMRVGIHS
210 220 230 240 250
GRVHCGVLGL RKWQFDVWSN DVTLANHMEA GGKAGRIHIT KATLNYLNGD
260 270 280 290 300
YEVEPGCGGE RNAYLKEHSI ETFLILRCTQ KRKEEKAMIA KMNRQRTNSI
310 320 330 340 350
GHNPPHWGAE RPFYNHLGGN QVSKEMKRMG FEDPKDKNAQ ESANPEDEVD
360 370 380 390 400
EFLGRAIDAR SIDRLRSEHV RKFLLTFREP DLEKKYSKQV DDRFGAYVAC
410 420 430 440 450
ASLVFLFICF VQITIVPHSI FMLSFYLTCS LLLTLVVFVS VIYSCVKLFP
460 470 480 490 500
SPLQTLSRKI VRSKMNSTLV GVFTITLVFL AAFVNMFTCN SRDLLGCLAQ
510 520 530 540 550
EHNISASQVN ACHVAESAVN YSLGDEQGFC GSPWPNCNFP EYFTYSVLLS
560 570 580 590 600
LLACSVFLQI SCIGKLVLML AIELIYVLIV EVPGVTLFDN ADLLVTANAI
610 620 630 640 650
DFFNNGTSQW SLCENLRHRR MEAGTYFPSG VKEQSPEHAT KVALKVVTPI
660 670 680 690 700
IISVFVLALY LHAQQVESTA RLDFLWKLQA TEEKEEMEEL QAYNRRLLHN
710 720 730 740 750
ILPKDVAAHF LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE
760 770 780 790 800
GVECLRLLNE IIADFDEIIS EDRFRQLEKI KTIGSTYMAA SGLNDSTYDK
810 820 830 840 850
VGKTHIKALA DFAMKLMDQM KYINEHSFNN FQMKIGLNIG PVVAGVIGAR
860 870 880 890 900
KPQYDIWGNT VNVASRMDST GVPDRIQVTT DMYQVLAANT YQLECRGVVK
910
VKGKGEMMTY FLNGGPPLS
Length:919
Mass (Da):103,868
Last modified:September 2, 2008 - v1
Checksum:iDC89BB6B6C4D9F6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025571 Genomic DNA No translation available.
AC112503 Genomic DNA No translation available.
AK124691 mRNA Translation: BAG54070.1
RefSeqiXP_006713546.1, XM_006713483.1
UniGeneiHs.593292

Genome annotation databases

EnsembliENST00000491190; ENSP00000418537; ENSG00000173175
GeneIDi111
UCSCiuc003egg.3 human

Similar proteinsi

Entry informationi

Entry nameiB3KWA8_HUMAN
AccessioniPrimary (citable) accession number: B3KWA8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health