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B3KWA8

- B3KWA8_HUMAN

UniProt

B3KWA8 - B3KWA8_HUMAN

Protein
Submitted name:

Adenylate cyclase type 5

Gene

ADCY5

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. adenylate cyclase activity Source: InterPro
    2. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Nucleotide-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Adenylate cyclase type 5Imported
    Submitted name:
    cDNA FLJ42701 fis, clone BRAMY3004919, highly similar to Adenylate cyclase type 5 (EC 4.6.1.1)Imported
    Gene namesi
    Name:ADCY5Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:236. ADCY5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    SMRiB3KWA8. Positions 87-276, 722-913.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    KOiK08045.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3KWA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSRFRTQL ELVSNVLIFS CTNIVGVCTH YPAEVSQRQA FQETRECIQA    50
    RLHSQRENQQ QERLLLSVLP RHVAMEMKAD INAKQEDMMF HKIYIQKHDN 100
    VSILFADIEG FTSLASQCTA QELVMTLNEL FARFDKLAAE NHCLRIKILG 150
    DCYYCVSGLP EARADHAHCC VEMGMDMIEA ISLVREVTGV NVNMRVGIHS 200
    GRVHCGVLGL RKWQFDVWSN DVTLANHMEA GGKAGRIHIT KATLNYLNGD 250
    YEVEPGCGGE RNAYLKEHSI ETFLILRCTQ KRKEEKAMIA KMNRQRTNSI 300
    GHNPPHWGAE RPFYNHLGGN QVSKEMKRMG FEDPKDKNAQ ESANPEDEVD 350
    EFLGRAIDAR SIDRLRSEHV RKFLLTFREP DLEKKYSKQV DDRFGAYVAC 400
    ASLVFLFICF VQITIVPHSI FMLSFYLTCS LLLTLVVFVS VIYSCVKLFP 450
    SPLQTLSRKI VRSKMNSTLV GVFTITLVFL AAFVNMFTCN SRDLLGCLAQ 500
    EHNISASQVN ACHVAESAVN YSLGDEQGFC GSPWPNCNFP EYFTYSVLLS 550
    LLACSVFLQI SCIGKLVLML AIELIYVLIV EVPGVTLFDN ADLLVTANAI 600
    DFFNNGTSQW SLCENLRHRR MEAGTYFPSG VKEQSPEHAT KVALKVVTPI 650
    IISVFVLALY LHAQQVESTA RLDFLWKLQA TEEKEEMEEL QAYNRRLLHN 700
    ILPKDVAAHF LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE 750
    GVECLRLLNE IIADFDEIIS EDRFRQLEKI KTIGSTYMAA SGLNDSTYDK 800
    VGKTHIKALA DFAMKLMDQM KYINEHSFNN FQMKIGLNIG PVVAGVIGAR 850
    KPQYDIWGNT VNVASRMDST GVPDRIQVTT DMYQVLAANT YQLECRGVVK 900
    VKGKGEMMTY FLNGGPPLS 919
    Length:919
    Mass (Da):103,868
    Last modified:September 2, 2008 - v1
    Checksum:iDC89BB6B6C4D9F6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC025571 Genomic DNA. No translation available.
    AC112503 Genomic DNA. No translation available.
    AK124691 mRNA. Translation: BAG54070.1.
    RefSeqiXP_006713546.1. XM_006713483.1.
    UniGeneiHs.593292.

    Genome annotation databases

    EnsembliENST00000491190; ENSP00000418537; ENSG00000173175.
    GeneIDi111.
    KEGGihsa:111.
    UCSCiuc003egg.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC025571 Genomic DNA. No translation available.
    AC112503 Genomic DNA. No translation available.
    AK124691 mRNA. Translation: BAG54070.1 .
    RefSeqi XP_006713546.1. XM_006713483.1.
    UniGenei Hs.593292.

    3D structure databases

    SMRi B3KWA8. Positions 87-276, 722-913.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000491190 ; ENSP00000418537 ; ENSG00000173175 .
    GeneIDi 111.
    KEGGi hsa:111.
    UCSCi uc003egg.2. human.

    Organism-specific databases

    CTDi 111.
    HGNCi HGNC:236. ADCY5.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    KOi K08045.

    Miscellaneous databases

    ChiTaRSi ADCY5. human.
    GenomeRNAii 111.
    NextBioi 35470403.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: AmygdalaImported.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB3KWA8_HUMAN
    AccessioniPrimary (citable) accession number: B3KWA8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3