B3KVV6 (B3KVV6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1 (A2ML1), mRNA EMBL BAG53918.1
Organism	Homo sapiens (Human) EMBL BAG53918.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1298 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	negative regulation of endopeptidase activity Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular space Inferred from electronic annotation. Source: InterPro
Molecular_function	endopeptidase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3KVV6 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 6874A62D8C3A039C	FASTA	1,298	143,660
	10 20 30 40 50 60 MVELQDPNSN RIAQWLEVVP EQGIVDLSFQ LAPEAMLGTY TVAVAEGKTF GTFSVEEYVL 70 80 90 100 110 120 PKFKVEVVEP KELSTVQESF LVKICCRYTY GKPMLGAVQV SVCQKANTYW YREVEREQLP 130 140 150 160 170 180 DKCRNLSGQT DKTGCFSAPV DMATFDLIGY AYSHQINIVA TVVEEGTGVE ANATQNIYIS 190 200 210 220 230 240 PQMGSMTFGD TSNFYHPNFP FSGKIRVRGH DDSFLKNHLV FLVIYGTNGT FNQTLVTDNN 250 260 270 280 290 300 GLAPFTLETS GWNGTDVSLE GKFQMEDLVY NPEQVPRYYQ NAYLHLRPFY STTRSFLGIH 310 320 330 340 350 360 RLNGPLKCGQ PQEVLVDYYI DPADASPDQE ISFSYYLIGK GSLVMEGQKH LNSKKKGLKA 370 380 390 400 410 420 SFSLSLTFTS RLAPDPSLVI YAIFPSGGVV ADKIQFSVEM CFDNQVSLGF SPSQQLPGAE 430 440 450 460 470 480 VELQLQAAPG SLCALRAVDE SVLLLRPDRE LSNRSVYGMF PFWYGHYPYQ VAEYDQCPVS 490 500 510 520 530 540 GPWDFPQPLI DPMPQGHSSQ RSIIWRPSFS EGTDLFSFFR DVGLKILSNA KIKKPVDCSH 550 560 570 580 590 600 RSPEYSTAMG AGGGHPEAFE SSTPLHQAED SQVRQYLPET WLWDLFPIGN SGKEAVHVTV 610 620 630 640 650 660 PDAITEWKAM SFCTSQSRGF GLSPTVGLTA FKPFFVDLTL PYSVVRGESF RLTATIFNYL 670 680 690 700 710 720 KDCIRVQTDL AKSHEYQLES WADSQTSSCL CADEAKTHHW NITAVKLGHI NFTISTKILD 730 740 750 760 770 780 SNEPCGGQKG FVPQKGRSDT LIKPVLVKPE GVLVEKTHSS LLCPKGKVAS ESVSLELPVD 790 800 810 820 830 840 IVPDSTKAYV TVLGDIMGTA LQNLDGLVQM PSGCGEQNMV LFAPIIYVLQ YLEKAGLLTE 850 860 870 880 890 900 EIRSRAVGFL EIGYQKELMY KHSNGSYSAF GERDGNGNTW LTAFVTKCFG QAQKFIFIDP 910 920 930 940 950 960 KNIQDALKWM AGNQLPSGCY ANVGNLLHTA MKGGVDDEVS LTAYVTAALL EMGKDVDDPM 970 980 990 1000 1010 1020 VSQGLWCLKN SATSTTNLYT QALLAYIFSL AGEMDIRNIL LKQLDQQAII SGESIYWSQK 1030 1040 1050 1060 1070 1080 PTPSSNASPW SEPAAVDVEL TAYALLAQLT KPSLTQKEIA KATSIVAWLA KQRNAYGGFS 1090 1100 1110 1120 1130 1140 STQDTVVALQ ALAKYATTAY VPSEEINLVV KSTENFQRTF NIQSVNRLVF QQDTLPNVPG 1150 1160 1170 1180 1190 1200 MYTLEASGQG CVYVQTVLRY NILPPTNMKT FSLSVEIGKA RCEQPTSPRS LTLTIHTSYV 1210 1220 1230 1240 1250 1260 GSRSSSNMAI VEVKMLSGFS PMEGTNQLLL QQPLVKKVEF GTDTLNIYLD ELIKNTQTYT 1270 1280 1290 FTISQSVLVT NLKPATIKVY DYYLPDEQAT IQYSDPCE

References

[1]

"NEDO human cDNA sequencing project." Ota T., Nakagawa S., Senoh A., Mizuguchi H., Inagaki H., Sugiyama T., Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H. , Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Tongue EMBL BAG53918.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123601 mRNA. Translation: BAG53918.1.
IPI	IPI00419215.
RefSeq	NP_653271.2. NM_144670.4.
UniGene	Hs.620532.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	I39.007.
Proteomic databases
PRIDE	B3KVV6.
Protocols and materials databases
DNASU	144568.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	144568.
KEGG	hsa:144568.
Organism-specific databases
CTD	144568.
PharmGKB	PA142670460.
Phylogenomic databases
HOVERGEN	HBG000039.
Family and domain databases
Gene3D	2.60.40.690. 1 hit.
InterPro	IPR009048. A-macroglobulin_rcpt-bd. IPR011626. A2M_comp. IPR002890. A2M_N. IPR011625. A2M_N_2. IPR001599. Macroglobln_a2. IPR019742. MacrogloblnA2_CS. IPR019565. MacrogloblnA2_thiol-ester-bond. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
Pfam	PF00207. A2M. 1 hit. PF07678. A2M_comp. 1 hit. PF01835. A2M_N. 1 hit. PF07703. A2M_N_2. 1 hit. PF07677. A2M_recep. 1 hit. PF10569. Thiol-ester_cl. 1 hit. [Graphical view]
SUPFAM	SSF49410. AM_receptor_bind. 1 hit. SSF48239. Terp_cyc_toroid. 1 hit.
PROSITE	PS00477. ALPHA_2_MACROGLOBULIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	144568.
NextBio	84957.

Entry information

Entry name

B3KVV6_HUMAN

Accession

Primary (citable) accession number: B3KVV6

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.