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Protein

Serine/threonine-protein phosphatase

Gene

PPP2CA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:PPP2CAImported
ORF Names:hCG_16586Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33663.

Expressioni

Gene expression databases

BgeeiENSG00000113575.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000418447.

Structurei

3D structure databases

SMRiB3KUN1. Positions 2-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 1196SER_THR_PHOSPHATASEInterPro annotation

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
HOVERGENiHBG000216.
KOiK04382.
OMAiWIENLMA.
OrthoDBiEOG091G0B6S.
PhylomeDBiB3KUN1.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3KUN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC
60 70 80 90 100
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL
110 120 130 140 150
VALKVRYRER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF
160 170 180 190 200
DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW
210 220 230 240 250
SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW
260 270 280 290 300
CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV

TRRTPDYFL
Length:309
Mass (Da):35,594
Last modified:September 2, 2008 - v1
Checksum:iC602291F78F34555
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei309 – 3091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097599 mRNA. Translation: BAG53493.1.
AB451240 mRNA. Translation: BAG70054.1.
AB451365 mRNA. Translation: BAG70179.1.
CH471062 Genomic DNA. Translation: EAW62268.1.
CH471062 Genomic DNA. Translation: EAW62269.1.
RefSeqiNP_002706.1. NM_002715.2.
UniGeneiHs.105818.

Genome annotation databases

GeneIDi5515.
KEGGihsa:5515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097599 mRNA. Translation: BAG53493.1.
AB451240 mRNA. Translation: BAG70054.1.
AB451365 mRNA. Translation: BAG70179.1.
CH471062 Genomic DNA. Translation: EAW62268.1.
CH471062 Genomic DNA. Translation: EAW62269.1.
RefSeqiNP_002706.1. NM_002715.2.
UniGeneiHs.105818.

3D structure databases

SMRiB3KUN1. Positions 2-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000418447.

Protocols and materials databases

DNASUi5515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5515.
KEGGihsa:5515.

Organism-specific databases

CTDi5515.
PharmGKBiPA33663.

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
HOVERGENiHBG000216.
KOiK04382.
OMAiWIENLMA.
OrthoDBiEOG091G0B6S.
PhylomeDBiB3KUN1.

Miscellaneous databases

ChiTaRSiPPP2CA. human.
GenomeRNAii5515.

Gene expression databases

BgeeiENSG00000113575.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3KUN1_HUMAN
AccessioniPrimary (citable) accession number: B3KUN1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.