B3KUG6 (B3KUG6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ39849 fis, clone SPLEN2014711, highly similar to Homo sapiens hect domain and RLD 6 (HERC6), transcript variant 1, mRNA EMBL BAG53428.1
Organism	Homo sapiens (Human) EMBL BAG53428.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	584 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SAAS SAAS000569

Ontologies

Keywords
Biological process	Ubl conjugation pathway SAAS SAAS000569
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from electronic annotation. Source: GOC
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3KUG6 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 720879865BF1D22D	FASTA	584	68,049
	10 20 30 40 50 60 MARDTFKKLT KKEWISSMIT TCLEDDLLRA LPCHSPHQEA LSVFLLLPEC PVMHDSKNWK 70 80 90 100 110 120 NLVVPFAKAV CEMSKQSLQV LKKCWAFLQE SSLNPLIQML KAAIISQLLH QTKTEQDHCN 130 140 150 160 170 180 VKALLGMMKE LHKVNKANCR LPENTFNINE LSNLLNFYID RGRQLFRDNH LIPAETPSPV 190 200 210 220 230 240 IFSDFPFIFN SLSKIKLLQA DSHIKMQMSE KKAYMLMHET ILQKKDEFPP SPRFILRVRR 250 260 270 280 290 300 SRLVKDALRQ LSQAEATDFC KVLVVEFINE ICPESGGVSS EFFHCMFEEM TKPEYGMFMY 310 320 330 340 350 360 PEMGSCMWFP AKPKPEKKRY FLFGMLCGLS LFNLNVANLP FPLALYKKLL DQKPSLEDLK 370 380 390 400 410 420 ELSPRLGKSL QEVLDDAADD IGDALCIRFS IHWDQNDVDL IPNGISIPVD QTNKRDYVSK 430 440 450 460 470 480 YIDYIFNVSV KAVYEEFQRG FYRVCEKEIL RHFYPEELMT AIIGNTDYDW KQFEQNSKYE 490 500 510 520 530 540 QGYQKSHPTI QLFWKAFHKL TLDEKKKFLF FLTGRDRLHA RGIQKMEIVF RCPETFSERD 550 560 570 580 HPTSITCHNI LSLPKYSTME RMEEALQVAI NNNRGFVSPM LTQS

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Spleen EMBL BAG53428.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK097168 mRNA. Translation: BAG53428.1.
IPI	IPI00455627.
UniGene	Hs.529317.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B3KUG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG103705.
Gene expression databases
ArrayExpress	B3KUG6.
Bgee	B3KUG6.
Family and domain databases
InterPro	IPR000569. HECT. [Graphical view]
Pfam	PF00632. HECT. 1 hit. [Graphical view]
SMART	SM00119. HECTc. 1 hit. [Graphical view]
SUPFAM	SSF56204. HECT. 1 hit.
PROSITE	PS50237. HECT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35470080.

Entry information

Entry name

B3KUG6_HUMAN

Accession

Primary (citable) accession number: B3KUG6

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	April 3, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.