ID B3KTL4_HUMAN Unreviewed; 625 AA. AC B3KTL4; DT 02-SEP-2008, integrated into UniProtKB/TrEMBL. DT 02-SEP-2008, sequence version 1. DT 27-MAR-2024, entry version 58. DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552}; DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG53126.1}; RN [1] {ECO:0000313|EMBL:BAG53126.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:BAG53126.1}; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., RA Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., RA Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., RA Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., RA Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., RA Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., RA Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., RA Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., RA Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., RA Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., RA Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., RA Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., RA Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., RA Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., RA Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). CC -!- SIMILARITY: Belongs to the DEAD box helicase family. CC {ECO:0000256|RuleBase:RU000492}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK095772; BAG53126.1; -; mRNA. DR AlphaFoldDB; B3KTL4; -. DR PeptideAtlas; B3KTL4; -. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC. DR CDD; cd17952; DEADc_DDX42; 1. DR CDD; cd18787; SF2_C_DEAD; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom. DR InterPro; IPR014001; Helicase_ATP-bd. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS. DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1. DR PANTHER; PTHR47958:SF170; DEAD-BOX ATP-DEPENDENT RNA HELICASE 24; 1. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2. DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492}; KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU000492}. FT DOMAIN 20..195 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51192" FT DOMAIN 223..374 FT /note="Helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51194" FT REGION 454..625 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 454..474 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 488..518 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 519..625 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 625 AA; 68001 MW; 32D7254226D4F592 CRC64; MHQIRKSEYT QPTPIQCQGV PVALSGRDMI GIAKTGSGKT AAFIWPMLIH IMDQKELEPG DGPIAVIVCP TRELCQQIHA ECKRFGKAYN LRSVAVYGGG SMWEQAKALQ EGAEIVVCTP GRLIDHVKKK ATNLQRVSYL VFDEADRMFD MGFEYQVRSI ASHVRPDRQT LLFSATFRKK IEKLARDILI DPIRVVQGDI GEANEDVTQI VEILHSGPSK WNWLTRRLVE FTSSGSVLLF VTKKANAEEL ANNLKQEGHN LGLLHGDMDQ SERNKVISDF KKKDIPVLVA TDVAARGLDI PSIKTVINYD VARDIDTLLT PKDSNFAGDL VRNLEGANQH VSKELLDLAM QNAWFRKSRF KGGKGKKLNI GGGGLGYRER PGLGSENMDR GNNNVMSNYE AYKPSTGAMG DRLTAMKAAF QSQYKSHFVA ASLSNQKAGS SAAGASGWTS AGSLNSVPTN SAQQGHNSPD SPVTSAAKGI PGFGNTGNIS GAPVTYPSAG AQGVNNTASG NNSREGTGGS NGKRERYTEN RGSSRHSHGE TGNRHSDSPR HGDGGRHGDG YRHPESSSRH TDGHRHGENR HGGSAGRHGE NRGANDGRNG ESRKEAFNRE SKMEPPKRKK SRWDS //