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B3KSM5

- B3KSM5_HUMAN

UniProt

B3KSM5 - B3KSM5_HUMAN

Protein
Submitted name:

cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. endopeptidase activator activity Source: Ensembl
    2. metalloenzyme activator activity Source: Ensembl

    GO - Biological processi

    1. bone morphogenesis Source: Ensembl
    2. cellular response to extracellular stimulus Source: Ensembl
    3. cellular response to X-ray Source: Ensembl
    4. chondrocyte development Source: Ensembl
    5. collagen fibril organization Source: Ensembl
    6. convergent extension involved in axis elongation Source: Ensembl
    7. digestive tract morphogenesis Source: Ensembl
    8. embryonic digit morphogenesis Source: Ensembl
    9. hematopoietic stem cell proliferation Source: Ensembl
    10. male gonad development Source: Ensembl
    11. negative regulation of BMP signaling pathway Source: Ensembl
    12. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    13. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    14. negative regulation of cell migration Source: Ensembl
    15. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    16. negative regulation of dermatome development Source: Ensembl
    17. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    18. negative regulation of gene expression Source: Ensembl
    19. negative regulation of JUN kinase activity Source: Ensembl
    20. negative regulation of mesodermal cell fate specification Source: Ensembl
    21. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    22. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
    23. neural tube closure Source: Ensembl
    24. patterning of blood vessels Source: Ensembl
    25. planar cell polarity pathway involved in neural tube closure Source: Ensembl
    26. positive regulation of angiogenesis Source: Ensembl
    27. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    28. positive regulation of catenin import into nucleus Source: Ensembl
    29. positive regulation of cell growth Source: Ensembl
    30. positive regulation of cell proliferation Source: Ensembl
    31. positive regulation of osteoblast differentiation Source: Ensembl
    32. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    33. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    34. post-anal tail morphogenesis Source: Ensembl
    35. regulation of stem cell division Source: Ensembl
    36. response to drug Source: Ensembl
    37. response to nutrient Source: Ensembl
    38. sclerotome development Source: Ensembl
    39. Wnt signaling pathway involved in somitogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinSAAS annotation

    Keywords - Biological processi

    Wnt signaling pathwaySAAS annotation

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    SecretedSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35693.

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiB3KSM5.

    Expressioni

    Gene expression databases

    ArrayExpressiB3KSM5.
    BgeeiB3KSM5.

    Family & Domainsi

    Sequence similaritiesi

    Contains FZ (frizzled) domain.SAAS annotation
    Contains NTR domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG052928.
    KOiK02176.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026558. SFRP2.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF45. PTHR11309:SF45. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3KSM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLPNLLGHE TMKEVLEQAG AWIPLVMKQC HPDTKKFLCS LFAPVCLDDL    50
    DETIQPCHSL CVQVKDRCAP VMSAFGFPWP DMLECDRFPQ DNDLCIPLAS 100
    SDHLLPATEE APKVCEACKN KNDDDNDIME TLCKNDFALK IKVKEITYIN 150
    RDTKIILETK SKTIYKLNGV SERDLKKSVL WLKDSLQCTC EEMNDINAPY 200
    LVMGQKQGGE LVITSVKRWQ KGQREFKRIS RSIRKLQC 238
    Length:238
    Mass (Da):27,239
    Last modified:September 2, 2008 - v1
    Checksum:iD925BA5E6BABE534
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093922 mRNA. Translation: BAG52787.1.
    RefSeqiNP_003004.1. NM_003013.2.
    UniGeneiHs.481022.

    Genome annotation databases

    GeneIDi6423.
    KEGGihsa:6423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093922 mRNA. Translation: BAG52787.1 .
    RefSeqi NP_003004.1. NM_003013.2.
    UniGenei Hs.481022.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I93.001.

    Proteomic databases

    PRIDEi B3KSM5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6423.
    KEGGi hsa:6423.

    Organism-specific databases

    CTDi 6423.
    PharmGKBi PA35693.

    Phylogenomic databases

    HOVERGENi HBG052928.
    KOi K02176.

    Miscellaneous databases

    GenomeRNAii 6423.
    NextBioi 24943.

    Gene expression databases

    ArrayExpressi B3KSM5.
    Bgeei B3KSM5.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR026558. SFRP2.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF45. PTHR11309:SF45. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: TracheaImported.

    Entry informationi

    Entry nameiB3KSM5_HUMAN
    AccessioniPrimary (citable) accession number: B3KSM5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.