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Protein
Submitted name:

cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation
Biological processWnt signaling pathwaySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35693.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 68PROSITE-ProRule annotation
Disulfide bondi61 ↔ 85PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiB3KSM5.
PeptideAtlasiB3KSM5.
PRIDEiB3KSM5.

Expressioni

Gene expression databases

BgeeiENSG00000145423.
GenevisibleiB3KSM5. HS.

Structurei

3D structure databases

SMRiB3KSM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 98FZ (frizzled)InterPro annotationAdd BLAST98
Domaini115 – 238NTRInterPro annotationAdd BLAST124

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOVERGENiHBG052928.
KOiK02176.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF124. PTHR11309:SF124. 1 hit.
PfamiView protein in Pfam
PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
SMARTiView protein in SMART
SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Complete.

B3KSM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPNLLGHE TMKEVLEQAG AWIPLVMKQC HPDTKKFLCS LFAPVCLDDL
60 70 80 90 100
DETIQPCHSL CVQVKDRCAP VMSAFGFPWP DMLECDRFPQ DNDLCIPLAS
110 120 130 140 150
SDHLLPATEE APKVCEACKN KNDDDNDIME TLCKNDFALK IKVKEITYIN
160 170 180 190 200
RDTKIILETK SKTIYKLNGV SERDLKKSVL WLKDSLQCTC EEMNDINAPY
210 220 230
LVMGQKQGGE LVITSVKRWQ KGQREFKRIS RSIRKLQC
Length:238
Mass (Da):27,239
Last modified:September 2, 2008 - v1
Checksum:iD925BA5E6BABE534
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093922 mRNA. Translation: BAG52787.1.
RefSeqiNP_003004.1. NM_003013.2.
UniGeneiHs.481022.

Genome annotation databases

GeneIDi6423.
KEGGihsa:6423.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB3KSM5_HUMAN
AccessioniPrimary (citable) accession number: B3KSM5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 5, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation