Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. endopeptidase activator activity Source: Ensembl
  2. metalloenzyme activator activity Source: Ensembl

GO - Biological processi

  1. bone morphogenesis Source: Ensembl
  2. cellular response to extracellular stimulus Source: Ensembl
  3. cellular response to X-ray Source: Ensembl
  4. chondrocyte development Source: Ensembl
  5. collagen fibril organization Source: Ensembl
  6. convergent extension involved in axis elongation Source: Ensembl
  7. digestive tract morphogenesis Source: Ensembl
  8. embryonic digit morphogenesis Source: Ensembl
  9. hematopoietic stem cell proliferation Source: Ensembl
  10. male gonad development Source: Ensembl
  11. negative regulation of BMP signaling pathway Source: Ensembl
  12. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  13. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  14. negative regulation of cell migration Source: Ensembl
  15. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  16. negative regulation of dermatome development Source: Ensembl
  17. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  18. negative regulation of gene expression Source: Ensembl
  19. negative regulation of JUN kinase activity Source: Ensembl
  20. negative regulation of mesodermal cell fate specification Source: Ensembl
  21. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  22. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
  23. neural tube closure Source: Ensembl
  24. patterning of blood vessels Source: Ensembl
  25. planar cell polarity pathway involved in neural tube closure Source: Ensembl
  26. positive regulation of angiogenesis Source: Ensembl
  27. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  28. positive regulation of catenin import into nucleus Source: Ensembl
  29. positive regulation of cell growth Source: Ensembl
  30. positive regulation of cell proliferation Source: Ensembl
  31. positive regulation of osteoblast differentiation Source: Ensembl
  32. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  33. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  34. post-anal tail morphogenesis Source: Ensembl
  35. regulation of stem cell division Source: Ensembl
  36. response to drug Source: Ensembl
  37. response to nutrient Source: Ensembl
  38. sclerotome development Source: Ensembl
  39. Wnt signaling pathway involved in somitogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotation

Keywords - Biological processi

Wnt signaling pathwaySAAS annotation

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35693.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiB3KSM5.

Expressioni

Gene expression databases

BgeeiB3KSM5.
ExpressionAtlasiB3KSM5. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotation
Contains NTR domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG052928.
KOiK02176.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3KSM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPNLLGHE TMKEVLEQAG AWIPLVMKQC HPDTKKFLCS LFAPVCLDDL
60 70 80 90 100
DETIQPCHSL CVQVKDRCAP VMSAFGFPWP DMLECDRFPQ DNDLCIPLAS
110 120 130 140 150
SDHLLPATEE APKVCEACKN KNDDDNDIME TLCKNDFALK IKVKEITYIN
160 170 180 190 200
RDTKIILETK SKTIYKLNGV SERDLKKSVL WLKDSLQCTC EEMNDINAPY
210 220 230
LVMGQKQGGE LVITSVKRWQ KGQREFKRIS RSIRKLQC
Length:238
Mass (Da):27,239
Last modified:September 2, 2008 - v1
Checksum:iD925BA5E6BABE534
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093922 mRNA. Translation: BAG52787.1.
RefSeqiNP_003004.1. NM_003013.2.
UniGeneiHs.481022.

Genome annotation databases

GeneIDi6423.
KEGGihsa:6423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093922 mRNA. Translation: BAG52787.1.
RefSeqiNP_003004.1. NM_003013.2.
UniGeneiHs.481022.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI93.001.

Proteomic databases

PRIDEiB3KSM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6423.
KEGGihsa:6423.

Organism-specific databases

CTDi6423.
PharmGKBiPA35693.

Phylogenomic databases

HOVERGENiHBG052928.
KOiK02176.

Miscellaneous databases

GenomeRNAii6423.
NextBioi24943.

Gene expression databases

BgeeiB3KSM5.
ExpressionAtlasiB3KSM5. baseline and differential.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TracheaImported.

Entry informationi

Entry nameiB3KSM5_HUMAN
AccessioniPrimary (citable) accession number: B3KSM5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 4, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.