B3KSM5 (B3KSM5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ36603 fis, clone TRACH2015180, highly similar to Secreted frizzled-related protein 2 EMBL BAG52787.1
Organism	Homo sapiens (Human) EMBL BAG52787.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FZ (frizzled) domain. SAAS SAAS015526 Contains 1 NTR domain. SAAS SAAS008993

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS015526
Cellular component	Secreted SAAS SAAS008993
Molecular function	Developmental protein SAAS SAAS015526
PTM	Disulfide bond SAAS SAAS015526
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway involved in somitogenesis Inferred from electronic annotation. Source: Compara bone morphogenesis Inferred from electronic annotation. Source: Compara cellular response to X-ray Inferred from electronic annotation. Source: Compara cellular response to extracellular stimulus Inferred from electronic annotation. Source: Compara chondrocyte development Inferred from electronic annotation. Source: Compara collagen fibril organization Inferred from electronic annotation. Source: Compara convergent extension involved in axis elongation Inferred from electronic annotation. Source: Compara digestive tract morphogenesis Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara hematopoietic stem cell proliferation Inferred from electronic annotation. Source: Compara male gonad development Inferred from electronic annotation. Source: Compara negative regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of JUN kinase activity Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cardiac muscle cell apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of dermatome development Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of mesodermal cell fate specification Inferred from electronic annotation. Source: Compara negative regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of planar cell polarity pathway involved in axis elongation Inferred from electronic annotation. Source: Compara neural tube closure Inferred from electronic annotation. Source: Compara patterning of blood vessels Inferred from electronic annotation. Source: Compara planar cell polarity pathway involved in neural tube closure Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of catenin import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara post-anal tail morphogenesis Inferred from electronic annotation. Source: Compara regulation of stem cell division Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara sclerotome development Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	endopeptidase activator activity Inferred from electronic annotation. Source: Compara metalloenzyme activator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B3KSM5 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: D925BA5E6BABE534	FASTA	238	27,239
	10 20 30 40 50 60 MRLPNLLGHE TMKEVLEQAG AWIPLVMKQC HPDTKKFLCS LFAPVCLDDL DETIQPCHSL 70 80 90 100 110 120 CVQVKDRCAP VMSAFGFPWP DMLECDRFPQ DNDLCIPLAS SDHLLPATEE APKVCEACKN 130 140 150 160 170 180 KNDDDNDIME TLCKNDFALK IKVKEITYIN RDTKIILETK SKTIYKLNGV SERDLKKSVL 190 200 210 220 230 WLKDSLQCTC EEMNDINAPY LVMGQKQGGE LVITSVKRWQ KGQREFKRIS RSIRKLQC

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Trachea EMBL BAG52787.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093922 mRNA. Translation: BAG52787.1.
IPI	IPI00027596.
RefSeq	NP_003004.1. NM_003013.2.
UniGene	Hs.481022.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B3KSM5.
Proteomic databases
PRIDE	B3KSM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6423.
KEGG	hsa:6423.
Organism-specific databases
CTD	6423.
PharmGKB	PA35693.
Phylogenomic databases
HOVERGEN	HBG052928.
KO	K02176.
Gene expression databases
ArrayExpress	B3KSM5.
Bgee	B3KSM5.
Family and domain databases
Gene3D	1.10.2000.10. 1 hit.
InterPro	IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR001134. Netrin_domain. IPR018933. Netrin_module_non-TIMP. IPR026558. SFRP2. IPR008993. TIMP-like_OB-fold. [Graphical view]
PANTHER	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF45. PTHR11309:SF45. 1 hit.
Pfam	PF01392. Fz. 1 hit. PF01759. NTR. 1 hit. [Graphical view]
SMART	SM00643. C345C. 1 hit. SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit. SSF50242. TIMP_like. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50189. NTR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6423.
NextBio	24943.

Entry information

Entry name

B3KSM5_HUMAN

Accession

Primary (citable) accession number: B3KSM5

Entry history

Integrated into UniProtKB/TrEMBL:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.