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B3KS15 (B3KS15_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphofructokinase PIRNR PIRNR000533
EC=2.7.1.11 PIRNR PIRNR000533
Alternative name(s):
Phosphohexokinase PIRNR PIRNR000533
OrganismHomo sapiens (Human) EMBL BAG52577.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. PIRNR PIRNR000533

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. PIRNR PIRNR000533

Sequence similarities

Belongs to the phosphofructokinase family. Two domains subfamily. PIRNR PIRNR000533

Sequences

Sequence LengthMass (Da)Tools
B3KS15 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: CB948AFC0E1A9185

FASTA77685,326
        10         20         30         40         50         60 
MCGYERCRPC RGAHGYLRGG QGVLHLRGLP GHGGRRLKHR RGRLGECLQH PASGAVRGDW 

        70         80         90        100        110        120 
REKPGCWSHR FPCPGRHALV GGTIIGSARC QAFRTREGRL KAACNLLQRG ITNLCVIGGD 

       130        140        150        160        170        180 
GSLTGANLFR KEWSGLLEEL ARNGQIDKEA VQKYAYLNVV GMVGSIDNDF CGTDMTIGTD 

       190        200        210        220        230        240 
SALHRIIEVV DAIMTTAQSH QRTFVLEVMG RHCGYLALVS ALACGADWVF LPESPPEEGW 

       250        260        270        280        290        300 
EEQMCVKLSE NRARKKRLNI IIVAEGAIDT QNKPITSEKI KELVVTQLGY DTRVTILGHV 

       310        320        330        340        350        360 
QRGGTPSAFD RILASRMGVE AVIALLEATP DTPACVVSLN GNHAVRLPLM ECVQMTQDVQ 

       370        380        390        400        410        420 
KAMDERRFQD AVRLRGRSFA GNLNTYKRLA IKLPDDQIPK TNCNVAVINV GAPAAGMNAA 

       430        440        450        460        470        480 
VRSAVRVGIA DGHRMLAIYD GFDGFAKGQI KEIGWTDVGG WTGQGGSILG TKRVLPGKYL 

       490        500        510        520        530        540 
EEIATQMRTH SINALLIIGG FEAYLGLLEL SAAREKHEEF CVPMVMVPAT VSNNVPGSDF 

       550        560        570        580        590        600 
SIGADTALNT ITDTCDRIKQ SASGTKRRVF IIETMGGYCG YLANMGGLAA GADAAYIFEE 

       610        620        630        640        650        660 
PFDIRDLQSN VEHLTEKMKT TIQRGLVLRN ESCSENYTTD FIYQLYPEEG KGVFDCRKNV 

       670        680        690        700        710        720 
LGHMQQGGAP SPFDRNFGTK ISARAMEWIT AKLKEARGRG KKFTTDDSIC VLGISKRNVI 

       730        740        750        760        770 
FQPVAELKKQ TDFEHRIPKE QWWLKLRPLM KILAKYKASY DVSDSGQLEH VQPWSV

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References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Prostate EMBL BAG52577.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK092597 mRNA. Translation: BAG52577.1.
IPIIPI00643196.
RefSeqNP_001229268.1. NM_001242339.1.
UniGeneHs.26010.

3D structure databases

ProteinModelPortalB3KS15.
ModBaseSearch...

Protein-protein interaction databases

STRINGB3KS15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5214.
KEGGhsa:5214.

Organism-specific databases

CTD5214.
PharmGKBPA33217.

Phylogenomic databases

HOVERGENHBG000976.

Family and domain databases

InterProIPR009161. 6-phosphofructokinase_euk.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
KOK00850.
PfamPF00365. PFK. 2 hits.
[Graphical view]
PIRSFPIRSF000533. ATP_PFK_euk. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. Ppfruckinase. 2 hits.
TIGRFAMsTIGR02478. 6PF1K_euk. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3KS15_HUMAN
AccessionPrimary (citable) accession number: B3KS15
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info