ID   B3KRE0_HUMAN            Unreviewed;       365 AA.
AC   B3KRE0;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   SubName: Full=cDNA FLJ34086 fis, clone FCBBF3005320, highly similar to Double-stranded RNA-binding protein Staufen homolog 1 {ECO:0000313|EMBL:BAG52352.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG52352.1};
RN   [1] {ECO:0000313|EMBL:BAG52352.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAG52352.1};
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA   Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S.,
RA   Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S.,
RA   Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H.,
RA   Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M.,
RA   Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M.,
RA   Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y.,
RA   Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N.,
RA   Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S.,
RA   Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T.,
RA   Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M.,
RA   Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y.,
RA   Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y.,
RA   Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T.,
RA   Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
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DR   EMBL; AK091405; BAG52352.1; -; mRNA.
DR   RefSeq; NP_001032405.1; NM_001037328.2.
DR   RefSeq; NP_001306063.1; NM_001319134.1.
DR   RefSeq; NP_001306064.1; NM_001319135.1.
DR   RefSeq; NP_004593.2; NM_004602.3.
DR   RefSeq; NP_059346.2; NM_017452.3.
DR   RefSeq; NP_059347.2; NM_017453.3.
DR   RefSeq; NP_059348.2; NM_017454.3.
DR   AlphaFoldDB; B3KRE0; -.
DR   PeptideAtlas; B3KRE0; -.
DR   DNASU; 6780; -.
DR   GeneID; 6780; -.
DR   KEGG; hsa:6780; -.
DR   CTD; 6780; -.
DR   PharmGKB; PA36188; -.
DR   OrthoDB; 2882160at2759; -.
DR   BioGRID-ORCS; 6780; 20 hits in 1168 CRISPR screens.
DR   GenomeRNAi; 6780; -.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd19885; DSRM_STAU1_rpt4; 1.
DR   CDD; cd19887; DSRM_STAU1_rpt5; 1.
DR   Gene3D; 3.30.160.20; -; 3.
DR   Gene3D; 6.10.250.1360; -; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR032478; Staufen_C.
DR   PANTHER; PTHR46054:SF2; DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1; 1.
DR   PANTHER; PTHR46054; MATERNAL EFFECT PROTEIN STAUFEN; 1.
DR   Pfam; PF00035; dsrm; 2.
DR   Pfam; PF16482; Staufen_C; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   PROSITE; PS50137; DS_RBD; 2.
DR   Genevisible; B3KRE0; HS.
PE   2: Evidence at transcript level;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00266}.
FT   DOMAIN          1..39
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          74..142
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   REGION          49..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  40001 MW;  89DC9AB32A76E31C CRC64;
     MKNFVTKVSV GEFVGEGEGK SKKISKKNAA IAVLEELKKL PPLPAVERVK PRIKKKTKPI
     VKPQTSPEYG QGINPISRLA QIQQAKKEKE PEYTLLTERG LPRRREFVMQ VKVGNHTAEG
     TGTNKKVAKR NAAENMLEIL GFKVPQAQPT KPALKSEEKT PIKKPGDGRK VTFFEPGSGD
     ENGTSNKEDE FRMPYLSHQQ LPAGILPMVP EVAQAVGVSQ GHHTKDFTRA APNPAKATVT
     AMIARELLYG GTSPTAETIL KNNISSGHVP HGPLTRPSEQ LDYLSRVQGF QVEYKDFPKN
     NKNEFVSLIN CSSQPPLISH GIGKDVESCH DMAALNILKL LSELDQQSTE MPRTGNGPMS
     VCGRC
//