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B3KPF0

- B3KPF0_HUMAN

UniProt

B3KPF0 - B3KPF0_HUMAN

Protein
Submitted name:

cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
    2. positive regulation of MAPK cascade Source: Ensembl
    3. regulation of cell growth Source: Ensembl
    4. regulation of glucose metabolic process Source: Ensembl
    5. type B pancreatic cell proliferation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA FLJ31712 fis, clone NT2RI2006445, highly similar to Insulin-like growth factor-binding protein 3Imported
    Submitted name:
    cDNA FLJ34387 fis, clone HCHON1000191, highly similar to Insulin-like growth factor-binding protein 3Imported
    Submitted name:
    cDNA FLJ38550 fis, clone HCHON2002123, highly similar to Insulin-like growth factor-binding protein 3Imported
    Submitted name:
    cDNA PSEC0177 fis, clone OVARC1000287, highly similar to Insulin-like growth factor-binding protein 3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29705.

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000253012.
    HOVERGENiHBG101822.
    KOiK10138.

    Family and domain databases

    Gene3Di4.10.800.10. 1 hit.
    InterProiIPR012211. IGFBP-3.
    IPR009168. IGFBP1-6.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF3. PTHR11551:SF3. 1 hit.
    PfamiPF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    SMARTiSM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57610. SSF57610. 1 hit.
    PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B3KPF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDTLNHLKF LNVLSPRGVH IPNCDKKGFY KKKQCRPSKG RKRGFCWCVD   50
    KYGQPLPGYT TKGKEDVHCY SMQSK 75
    Length:75
    Mass (Da):8,708
    Last modified:September 2, 2008 - v1
    Checksum:i8BBDFD878FFD01CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056274 mRNA. Translation: BAG51662.1.
    AK075483 mRNA. Translation: BAG52153.1.
    AK091706 mRNA. Translation: BAG52402.1.
    AK095869 mRNA. Translation: BAG53151.1.
    RefSeqiNP_000589.2. NM_000598.4.
    UniGeneiHs.450230.

    Genome annotation databases

    GeneIDi3486.
    KEGGihsa:3486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056274 mRNA. Translation: BAG51662.1 .
    AK075483 mRNA. Translation: BAG52153.1 .
    AK091706 mRNA. Translation: BAG52402.1 .
    AK095869 mRNA. Translation: BAG53151.1 .
    RefSeqi NP_000589.2. NM_000598.4.
    UniGenei Hs.450230.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 3486.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3486.
    KEGGi hsa:3486.

    Organism-specific databases

    CTDi 3486.
    PharmGKBi PA29705.

    Phylogenomic databases

    HOGENOMi HOG000253012.
    HOVERGENi HBG101822.
    KOi K10138.

    Miscellaneous databases

    GenomeRNAii 3486.
    NextBioi 13708.

    Family and domain databases

    Gene3Di 4.10.800.10. 1 hit.
    InterProi IPR012211. IGFBP-3.
    IPR009168. IGFBP1-6.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF3. PTHR11551:SF3. 1 hit.
    Pfami PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    SMARTi SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57610. SSF57610. 1 hit.
    PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: OvaryImported.

    Entry informationi

    Entry nameiB3KPF0_HUMAN
    AccessioniPrimary (citable) accession number: B3KPF0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.