ID   B3KPE6_HUMAN            Unreviewed;       707 AA.
AC   B3KPE6;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   SubName: Full=Zinc finger protein 608 {ECO:0000313|EMBL:BAG51658.1, ECO:0000313|Ensembl:ENSP00000421899};
DE   Flags: Fragment;
GN   Name=ZNF608 {ECO:0000313|Ensembl:ENSP00000421899};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG51658.1};
RN   [1] {ECO:0000313|EMBL:BAG51658.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA   Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S.,
RA   Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S.,
RA   Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H.,
RA   Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M.,
RA   Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M.,
RA   Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y.,
RA   Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N.,
RA   Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S.,
RA   Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T.,
RA   Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M.,
RA   Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y.,
RA   Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y.,
RA   Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T.,
RA   Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000421899, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3] {ECO:0007829|PubMed:19413330}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [4] {ECO:0000313|Ensembl:ENSP00000421899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [6] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [7] {ECO:0007829|PubMed:28112733}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
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DR   EMBL; AC112196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC113398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK056247; BAG51658.1; -; mRNA.
DR   RefSeq; NP_065798.2; NM_020747.2.
DR   AlphaFoldDB; B3KPE6; -.
DR   SMR; B3KPE6; -.
DR   MassIVE; B3KPE6; -.
DR   MaxQB; B3KPE6; -.
DR   PeptideAtlas; B3KPE6; -.
DR   ProteomicsDB; 3528; -.
DR   Antibodypedia; 1014; 115 antibodies from 25 providers.
DR   DNASU; 57507; -.
DR   Ensembl; ENST00000513986; ENSP00000421899; ENSG00000168916.
DR   GeneID; 57507; -.
DR   KEGG; hsa:57507; -.
DR   UCSC; uc063gmm.1; human.
DR   CTD; 57507; -.
DR   HGNC; HGNC:29238; ZNF608.
DR   OpenTargets; ENSG00000168916; -.
DR   PharmGKB; PA134945727; -.
DR   VEuPathDB; HostDB:ENSG00000168916; -.
DR   OMA; PNCAMDE; -.
DR   OrthoDB; 5406990at2759; -.
DR   BioGRID-ORCS; 57507; 12 hits in 1156 CRISPR screens.
DR   ChiTaRS; ZNF608; human.
DR   GenomeRNAi; 57507; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000168916; Expressed in cardiac muscle of right atrium and 165 other cell types or tissues.
DR   ExpressionAtlas; B3KPE6; baseline and differential.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   InterPro; IPR040010; ZN608/ZN609.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR21564; BRAKELESS PROTEIN; 1.
DR   PANTHER; PTHR21564:SF4; ZINC FINGER PROTEIN 608; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:B3KPE6,
KW   ECO:0007829|MaxQB:B3KPE6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          555..578
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS00028"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          260..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          417..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..513
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..543
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         707
FT                   /evidence="ECO:0000313|EMBL:BAG51658.1"
SQ   SEQUENCE   707 AA;  73508 MW;  F45EF679379AABE0 CRC64;
     MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM NNSTTTTSSS
     NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE TSKSKVKRSK TSKDANKSLP
     SAALYGIPEI SSTGKRQEVQ GRPGEATGMN SALGQSVSSG GSGNPNSNST STSTSAATAG
     AGSCGKSKEE KPGKSQSSRG AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA
     KSNGGGASPF HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT
     EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV GVNTCEVGVV
     TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT YVGTLLDCTK HDWAPPRFCE
     SPTSDLEMRG GRGRGKRARS AAAAPGSEAS FTESRGLQNK NRGGANGKGR RGSLNASGRR
     TPPNCAAEDI KASPSSTNKR KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET
     TFLDQGCSSP VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE
     GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS IIGAKAGKNS
     GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL EAEGLID
//