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Protein
Submitted name:

Sec61 alpha 1 subunit (S. cerevisiae), isoform CRA_c

Gene

SEC61A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Sec61 alpha 1 subunit (S. cerevisiae), isoform CRA_cImported
Submitted name:
cDNA FLJ14517 fis, clone NT2RM1000833, highly similar to Protein transport protein Sec61 subunit alpha isoform 1Imported
Submitted name:
cDNA FLJ90225 fis, clone NT2RM1000855, highly similar to Protein transport protein Sec61 subunit alpha isoform 1Imported
Gene namesi
Name:SEC61A1Imported
ORF Names:hCG_40108Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 54HelicalSequence analysisAdd BLAST23
Transmembranei74 – 97HelicalSequence analysisAdd BLAST24
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Transmembranei143 – 165HelicalSequence analysisAdd BLAST23
Transmembranei172 – 193HelicalSequence analysisAdd BLAST22
Transmembranei205 – 221HelicalSequence analysisAdd BLAST17
Transmembranei242 – 263HelicalSequence analysisAdd BLAST22
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei413 – 431HelicalSequence analysisAdd BLAST19
Transmembranei437 – 458HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901772.

Expressioni

Gene expression databases

BgeeiENSG00000058262.
ExpressionAtlasiB3KNF6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000243253.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 74Plug_transloconInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
HOVERGENiHBG055271.
KOiK10956.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3KNF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL
160 170 180 190 200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES
360 370 380 390 400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQSEVGS MGALLF
Length:476
Mass (Da):52,265
Last modified:September 2, 2008 - v1
Checksum:i44A9B7B37C7C82E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027423 mRNA. Translation: BAG51318.1.
AK074706 mRNA. Translation: BAG51989.1.
CH471052 Genomic DNA. Translation: EAW79326.1.
CH471052 Genomic DNA. Translation: EAW79327.1.
RefSeqiNP_037468.1. NM_013336.3.
UniGeneiHs.518236.

Genome annotation databases

GeneIDi29927.
KEGGihsa:29927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027423 mRNA. Translation: BAG51318.1.
AK074706 mRNA. Translation: BAG51989.1.
CH471052 Genomic DNA. Translation: EAW79326.1.
CH471052 Genomic DNA. Translation: EAW79327.1.
RefSeqiNP_037468.1. NM_013336.3.
UniGeneiHs.518236.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000243253.

Protocols and materials databases

DNASUi29927.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29927.
KEGGihsa:29927.

Organism-specific databases

CTDi29927.
PharmGKBiPA134901772.

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
HOVERGENiHBG055271.
KOiK10956.

Miscellaneous databases

ChiTaRSiSEC61A1. human.
GenomeRNAii29927.

Gene expression databases

BgeeiENSG00000058262.
ExpressionAtlasiB3KNF6. baseline and differential.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB3KNF6_HUMAN
AccessioniPrimary (citable) accession number: B3KNF6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.