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Protein

Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

Gene

FTSJ1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(32)/guanosine(34) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei55S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei75S-adenosyl-L-methionineUniRule annotation1
Binding sitei91S-adenosyl-L-methionineUniRule annotation1
Binding sitei116S-adenosyl-L-methionineUniRule annotation1
Active sitei156Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

tRNA processingUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferaseUniRule annotation (EC:2.1.1.205UniRule annotation)
Alternative name(s):
2'-O-ribose RNA methyltransferase TRM7 homologUniRule annotation
Protein ftsJ homolog 1UniRule annotation
Gene namesi
Name:FTSJ1UniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28417.

PTM / Processingi

Proteomic databases

PaxDbiB3KN91.
PeptideAtlasiB3KN91.
PRIDEiB3KN91.

Expressioni

Gene expression databases

GenevisibleiB3KN91. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326948.

Structurei

3D structure databases

ProteinModelPortaliB3KN91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 199FtsJInterPro annotationAdd BLAST179

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1099. Eukaryota.
COG0293. LUCA.
HOGENOMiHOG000162368.
HOVERGENiHBG017749.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E. 1 hit.
MF_03162. RNA_methyltr_E_TRM7. 1 hit.
InterProiIPR028590. RNA_methyltr_E_Trm7.
IPR015507. rRNA-MeTfrase_E.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 1 hit.
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

B3KN91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRTSKDKRD VYYRLAKENG WRARSAFKLL QLDKEFQLFQ GVTRAVDLCA
60 70 80 90 100
APGSWSQVLS RKIGGQGSGH VVAVDLQAMA PLPGVVQIQG DITQLSTAKE
110 120 130 140 150
IIQHFKGCPA DLVVCDGAPD VTGLHDVDEY MQAQLLLAAL NIATHVLKPG
160 170 180 190 200
GCFVAKIFRG RDVTLLYSQL QVFFSSVLCA KPRSSRNSSI EAFAVCQGYD
210 220 230 240 250
PPEGFIPDLS KPLLDHSYDF NQLDGPTRII VPFVTCGDLS SYDSDRSYPL
260 270 280 290 300
DLEGGSEYKY TPPTQPPISP PYQEACTLKR KGQLAKEIRP QDCPISRVDT
310 320
FPQPLAAPQC HTLLAPEMED NEMSCSP
Length:327
Mass (Da):35,895
Last modified:September 2, 2008 - v1
Checksum:i97417C32D8515DF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024023 mRNA. Translation: BAG51253.1.
RefSeqiNP_803188.1. NM_177439.2.
UniGeneiHs.23170.

Genome annotation databases

GeneIDi24140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024023 mRNA. Translation: BAG51253.1.
RefSeqiNP_803188.1. NM_177439.2.
UniGeneiHs.23170.

3D structure databases

ProteinModelPortaliB3KN91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326948.

Proteomic databases

PaxDbiB3KN91.
PeptideAtlasiB3KN91.
PRIDEiB3KN91.

Protocols and materials databases

DNASUi24140.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24140.

Organism-specific databases

CTDi24140.
PharmGKBiPA28417.

Phylogenomic databases

eggNOGiKOG1099. Eukaryota.
COG0293. LUCA.
HOGENOMiHOG000162368.
HOVERGENiHBG017749.

Miscellaneous databases

ChiTaRSiFTSJ1. human.
GenomeRNAii24140.

Gene expression databases

GenevisibleiB3KN91. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E. 1 hit.
MF_03162. RNA_methyltr_E_TRM7. 1 hit.
InterProiIPR028590. RNA_methyltr_E_Trm7.
IPR015507. rRNA-MeTfrase_E.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 1 hit.
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB3KN91_HUMAN
AccessioniPrimary (citable) accession number: B3KN91
Entry historyi
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 5, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.