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B3HUL8 (B3HUL8_ECOLX) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333 EMBL EDV66368.1
ORF Names:EcF11_4906 EMBL EDV66368.1
OrganismEscherichia coli F11 EMBL EDV66368.1
Taxonomic identifier340197 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Cofactor

Manganese By similarity. HAMAP MF_00333

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region48 – 5710Important for dimerization By similarity HAMAP MF_00333
Region108 – 1103Substrate binding By similarity HAMAP MF_00333
Region240 – 27536Important for dimerization By similarity HAMAP MF_00333
Region258 – 2636Substrate binding By similarity HAMAP MF_00333

Sites

Active site1061Proton donor By similarity HAMAP MF_00333
Binding site921Substrate By similarity HAMAP MF_00333
Site1751Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
B3HUL8 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: DC689C92CD71AE9B

FASTA29934,304
        10         20         30         40         50         60 
MKPDAHQVKQ FLLNLQDTIC QQLSAVDGAE FVEDSWQREA GGGGRSRVLR NGGVFEQAGV 

        70         80         90        100        110        120 
NFSHVHGEAM PASATAHRPE LAGRSFEAMG VSLVVHPHNP YVPTSHANVR FFIAEKPGAE 

       130        140        150        160        170        180 
PVWWFGGGFD LTPFYGFEED AIHWHRTARD LCLPFGEDVY PRYKKWCDEY FYLKHRNEQR 

       190        200        210        220        230        240 
GIGGLFFDDL NTPDFDHCFA FMQAVGKGYT DAYLPIVERR KAMAYGERER NFQLYRRGRY 

       250        260        270        280        290 
VEFNLVWDRG TLFGLQTGGR TESILMSMPP LVRWEYDYQP KDGSPEAALS EFIKVRDWV

« Hide

References

[1]Rasko D.A., Rosovitz M.J., Mobley H.L.T., Myers G.S.A., Seshadri R., Cer R.Z., Jiang L., Ravel J.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: F11 EMBL EDV66368.1.
[2]Rasko D., Rosovitz M., Myers G., Seshadri R., Cer R., Jiang L., Ravel J., Fricke W.F., Sebastian Y.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: F11 EMBL EDV66368.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAJU02000020 Genomic DNA. Translation: EDV66368.1.

3D structure databases

ProteinModelPortalB3HUL8.
SMRB3HUL8. Positions 8-299.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC26553971. VBIEscCol13398_3159.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3HUL8_ECOLX
AccessionPrimary (citable) accession number: B3HUL8
Entry history
Integrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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