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Protein

DNA topoisomerase 2

Gene

TOPII

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 2UniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:TOPIIImported
Synonyms:ATTOPIIImported, TOPOISOMERASE IIImported, topoisomerase IIImported
Ordered Locus Names:At3g23890Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G23890

Expressioni

Gene expression databases

ExpressionAtlasiB3H4G2 baseline and differential

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB3H4G2
SMRiB3H4G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini455 – 569ToprimInterPro annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1021 – 1041Sequence analysisAdd BLAST21
Coiled coili1163 – 1190Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0355 Eukaryota
COG0187 LUCA
COG0188 LUCA
HOGENOMiHOG000216693

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd03365 TOPRIM_TopoIIA, 1 hit
Gene3Di1.10.268.10, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
3.40.50.670, 2 hits
3.90.199.10, 3 hits
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR013506 Topo_IIA_bsu_dom2
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C
IPR006171 TOPRIM_domain
IPR034157 TOPRIM_TopoII
PANTHERiPTHR10169 PTHR10169, 1 hit
PfamiView protein in Pfam
PF00204 DNA_gyraseB, 1 hit
PF00521 DNA_topoisoIV, 1 hit
PF02518 HATPase_c, 1 hit
PF01751 Toprim, 1 hit
PF16898 TOPRIM_C, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00433 TOP2c, 1 hit
SM00434 TOP4c, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
SSF56719 SSF56719, 1 hit
PROSITEiView protein in PROSITE
PS00177 TOPOISOMERASE_II, 1 hit
PS50880 TOPRIM, 1 hit

Sequencei

Sequence statusi: Complete.

B3H4G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLPLQNS NAANVAKAPA KSRAAAGGKT IEEMYQKKSQ LEHILLRPDT
60 70 80 90 100
YIGSIEKHTQ TLWVYEKDEM VQRPVTYVPG LYKIFDEILV NAADNKQRDA
110 120 130 140 150
KMDSVQVVID VEQNLISVCN SGAGVPVEIH QEEGIYVPEM IFGHLLTSSN
160 170 180 190 200
YDDNVKKTTG GRNGYGAKLT NIFSTEFIIE TADGKRLKKY KQVFENNMGK
210 220 230 240 250
KSEPVITKCN KSENWTKVTF KPDLKKFNMT ELEDDVVALM SKRVFDIAGC
260 270 280 290 300
LGKSVKVELN GKQIPVKSFT DYVDLYLSAA NKSRTEDPLP RLTEKVNDRW
310 320 330 340 350
EVCVSLSEGQ FQQVSFVNSI ATIKGGTHVD YVTSQITNHI VAAVNKKNKN
360 370 380 390 400
ANVKAHNVKN HLWVFVNALI DNPAFDSQTK ETLTLRQSSF GSKCELSEDF
410 420 430 440 450
LKKVGKSGVV ENLLSWADFK QNKDLKKSDG AKTGRVLVEK LDDAAEAGGK
460 470 480 490 500
NSRLCTLILT EGDSAKSLAL AGRSVLGNNY CGVFPLRGKL LNVREASTTQ
510 520 530 540 550
ITNNKEIENL KKILGLKQNM KYENVNSLRY GQMMIMTDQD HDGSHIKGLL
560 570 580 590 600
INFIHSFWPS LLQVPSFLVE FITPIVKATR KGTKKVLSFY SMPEYEEWKE
610 620 630 640 650
SLKGNATGWD IKYYKGLGTS TAEEGKEYFS NLGLHKKDFV WEDEQDGEAI
660 670 680 690 700
ELAFSKKKIE ARKNWLSSYV PGNHLDQRQP KVTYSDFVNK ELILFSMADL
710 720 730 740 750
QRSIPSMVDG LKPGQRKILF VAFKKIARKE MKVAQLVGYV SLLSAYHHGE
760 770 780 790 800
QSLASAIIGM AQDYVGSNNI NLLLPNGQFG TRTSGGKDSA SARYIFTKLS
810 820 830 840 850
PVTRILFPKD DDLLLDYLNE DGQRIEPTWY MPIIPTVLVN GAEGIGTGWS
860 870 880 890 900
TFIPNYNPRE IVANVRRLLN GESMVPMDPW YRGFKGTIEK TASKEGGCTY
910 920 930 940 950
TITGLYEEVD ETTIRITELP IRRWNDDYKN FLQSLKTDNG APFFQDVKAY
960 970 980 990 1000
NDEKSVDFDL ILSEENMLAA RQEGFLKKFK LTTTIATSNM HLFDKKGVIK
1010 1020 1030 1040 1050
KYVTPEQILE EFFDLRFEYY EKRKETVVKN MEIELLKLEN KARFILAVLS
1060 1070 1080 1090 1100
GEIIVNKRKK ADIVEDLRQK GFTPFPRKAE SVEAAIAGAV DDDAAEEPEE
1110 1120 1130 1140 1150
ILVDPESSSS YIPGSEYDYL LAMAIASLTI EKVEELLADR DKMIIAVADM
1160 1170 1180 1190 1200
KKTTPKSLWL SDLESLDKEL EKLDLKDAQV QQAIEAAQKK IRAKSGAAVK
1210 1220 1230 1240 1250
VKRQAPKKPA PKKTTKKASE SETTEASYSA MDTDNNVAEV VKPKGRQGAK
1260 1270 1280 1290 1300
KKAPAAAKEV EEDEMLDLAQ RLAQYNFGSA PADSSKTAET SKAIAVDDDD
1310 1320 1330 1340 1350
DDVVVEVAPV KKGGRKPAAT KAAKPPAAPR KRGKQTVAST EVLAIGVSPE
1360 1370 1380 1390 1400
KKVRKMRSSP FNKKSSSVMS RLADNKEEES SENVAGNSSS EKSGGDVSAI
1410 1420 1430
SRPQRANRRK MTYVLSDSES ESANDSEFDD IEDDEDDE
Length:1,438
Mass (Da):160,409
Last modified:July 22, 2008 - v1
Checksum:i8032F880F3403AC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002686 Genomic DNA Translation: AEE76827.1
RefSeqiNP_001118686.1, NM_001125214.2
UniGeneiAt.22343

Genome annotation databases

EnsemblPlantsiAT3G23890.2; AT3G23890.2; AT3G23890
GeneIDi821972
GrameneiAT3G23890.2; AT3G23890.2; AT3G23890

Similar proteinsi

Entry informationi

Entry nameiB3H4G2_ARATH
AccessioniPrimary (citable) accession number: B3H4G2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health