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B3H2X9

- XYLA_ACTP7

UniProt

B3H2X9 - XYLA_ACTP7

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Protein
Xylose isomerase
Gene
xylA, APP7_1997
Organism
Actinobacillus pleuropneumoniae serotype 7 (strain AP76)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011 By similarity
Active sitei104 – 1041 By similarity
Metal bindingi232 – 2321Magnesium 1 By similarity
Metal bindingi268 – 2681Magnesium 1 By similarity
Metal bindingi268 – 2681Magnesium 2 By similarity
Metal bindingi271 – 2711Magnesium 2 By similarity
Metal bindingi296 – 2961Magnesium 1 By similarity
Metal bindingi307 – 3071Magnesium 2 By similarity
Metal bindingi309 – 3091Magnesium 2 By similarity
Metal bindingi339 – 3391Magnesium 1 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAPLE537457:GJI0-2073-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:APP7_1997
OrganismiActinobacillus pleuropneumoniae serotype 7 (strain AP76)
Taxonomic identifieri537457 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001226: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Xylose isomeraseUniRule annotation
PRO_1000200273Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi537457.APP7_1997.

Structurei

3D structure databases

ProteinModelPortaliB3H2X9.
SMRiB3H2X9. Positions 2-439.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiSTDVEDM.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B3H2X9-1 [UniParc]FASTAAdd to Basket

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MSNYFDKIEK VKYEGADSTN PFAFKHYNPN EVILGKTMAE HLRLAVCYWH    50
TFCWTGNDMF GVGSLDRSWQ KTGDLLEGAK QKAEIAFEFF QKLGIPYYCF 100
HDVDIAPEGN SYKEYVHNFH TMVDILEKKQ AETGVKLLWG TANCFTNPRY 150
MSGASTNPNP EVFSWAASQV FNAMNATKRL GGENYVLWGG REGYETLLNT 200
DLKREREQIG RFMQMVVEHK HKIGFNGTLL IEPKPQEPTK HQYDYDVATV 250
YGFLKQFGLE KEIKVNIEAN HATLAGHTFQ HEIATAAALD IFGSIDANRG 300
DPQLGWDTDQ FPNSVEENTL VMYEILKAGG FTTGGFNFDA KIRRQSTDPY 350
DLFHGHIGAI DVLALSLKRA AKMIEDKTLQ GIVDQRYAGW NGDLGQQILA 400
GKASLEDLAK IVESKALDPK PVSGQQEYLE NLVNNYIYR 439
Length:439
Mass (Da):49,636
Last modified:July 22, 2008 - v1
Checksum:i93723DE3CF888C7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001091 Genomic DNA. Translation: ACE62649.1.
RefSeqiYP_001969791.1. NC_010939.1.

Genome annotation databases

EnsemblBacteriaiACE62649; ACE62649; APP7_1997.
GeneIDi6396480.
KEGGiapa:APP7_1997.
PATRICi20757809. VBIActPle116979_2048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001091 Genomic DNA. Translation: ACE62649.1 .
RefSeqi YP_001969791.1. NC_010939.1.

3D structure databases

ProteinModelPortali B3H2X9.
SMRi B3H2X9. Positions 2-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 537457.APP7_1997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACE62649 ; ACE62649 ; APP7_1997 .
GeneIDi 6396480.
KEGGi apa:APP7_1997.
PATRICi 20757809. VBIActPle116979_2048.

Phylogenomic databases

eggNOGi COG2115.
HOGENOMi HOG000252293.
KOi K01805.
OMAi STDVEDM.
OrthoDBi EOG62NX4R.

Enzyme and pathway databases

BioCyci APLE537457:GJI0-2073-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome analysis of A. pleuropneumoniae serotype 7."
    Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AP76.

Entry informationi

Entry nameiXYLA_ACTP7
AccessioniPrimary (citable) accession number: B3H2X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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