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B3H2S8 (B3H2S8_ACTP7) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419

Short name=FGAM synthase HAMAP-Rule MF_00419
Short name=FGAMS HAMAP-Rule MF_00419
EC=6.3.5.3 HAMAP-Rule MF_00419
Alternative name(s):
Formylglycinamide ribotide amidotransferase HAMAP-Rule MF_00419
Formylglycinamide ribotide synthetase HAMAP-Rule MF_00419
Gene names
Name:purL HAMAP-Rule MF_00419 EMBL ACE62395.1
Ordered Locus Names:APP7_1743 EMBL ACE62395.1
OrganismActinobacillus pleuropneumoniae serotype 7 (strain AP76) [Complete proteome] [HAMAP] EMBL ACE62395.1
Taxonomic identifier537457 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Protein attributes

Sequence length1298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00419 SAAS SAAS022940

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00419 SAAS SAAS022940

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00419 SAAS SAAS022940

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00419 SAAS SAAS022940.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00419

Contains glutamine amidotransferase type-1 domain. SAAS SAAS022940

Contains glutamine amidotransferase type-domain. SAAS SAAS022940

In the N-terminal section; belongs to the FGAMS family. HAMAP-Rule MF_00419

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding308 – 31912ATP By similarity HAMAP-Rule MF_00419

Sites

Active site11381Nucleophile By similarity HAMAP-Rule MF_00419
Active site12631 By similarity HAMAP-Rule MF_00419
Active site12651 By similarity HAMAP-Rule MF_00419

Sequences

Sequence LengthMass (Da)Tools
B3H2S8 [UniParc].

Last modified July 22, 2008. Version 1.
Checksum: C52E931B0B9C035A

FASTA1,298142,534
        10         20         30         40         50         60 
MTVQTFRGSP ALSEFRLNQF QTKFQQNALP VKSVYAEYVH FVDLNAELSA AQTAEIKELL 

        70         80         90        100        110        120 
HYGPTLAEHE PVGFCLIVTP RIGTISSWSS KATDIAHNCG LQAVNRIERG LAYYFEFSAE 

       130        140        150        160        170        180 
PTAAQIETLK GLLHDRMLET VLDNEAQAAN LFAQQEPKPF TTVDILNGGR KALEEANVNL 

       190        200        210        220        230        240 
GLALADDEID YLVENFTALK RNPNDIELYM FAQANSEHCR HKIFNADWTI DGQKQEKSLF 

       250        260        270        280        290        300 
KMIKNTFEKT PDYVLSAYKD NAAVMEGSKV GRWFPDQDGQ YRAHQEDAHI LMKVETHNHP 

       310        320        330        340        350        360 
TAISPFPGAA TGSGGEIRDE GATGRGAKPK AGLTGFSVSN LVIPNFEQPW ENPLSKPHRI 

       370        380        390        400        410        420 
ASALDIMIEG PLGGAAFNNE FGRPALLGYF RTYEEKVNSF AGEEVRGYHK PIMLAGGIGN 

       430        440        450        460        470        480 
IRAEHVQKGE IPVGAKLIVL GGPAMNIGLG GGAASSMASG KSKEDLDFAS VQRENPEMER 

       490        500        510        520        530        540 
RCQEVIDRCW QLGEDNPILF IHDVGAGGLS NAMPELVHDG DRGGKFDLRK ILCDEKGMSP 

       550        560        570        580        590        600 
LEIWCNESQE RYVLAVSPEK LALFTELCER ERAPFAVIGE ATEEKHLTLK DDHFDNNPID 

       610        620        630        640        650        660 
LPMNVLLGKT PKMHRDVSSK TVENQPLDSQ QIQLKEALHR VLRLPVVAEK TFLITIGDRT 

       670        680        690        700        710        720 
VTGMVARDQM VGPWQIPVAD CAVTTASLDS YHGEAMSMGE RAPVALLDFG ASARLAVAES 

       730        740        750        760        770        780 
ITNIAATNIG ELKRIKLSAN WMSAAGHEGE DAGLYEAVKA VGEELCPALG ITIPVGKDSM 

       790        800        810        820        830        840 
SMRTTWEENG EQKSVTAPLS LVISAFARVE DVRKTVTPQL RTDKGLSSLL LLDLGEGKNR 

       850        860        870        880        890        900 
LGATALAQVY KQLGDKPADV VNVESLKNFF NAMQTLVAED KLLAYHDRSD GGLITTLAEM 

       910        920        930        940        950        960 
TFAGNCGVEI DISALGDDDL AVLFNEELGA VIQVKDADLA RVREVLNAHN LLGLTKDLGT 

       970        980        990       1000       1010       1020 
VHEDDRFVIS RGSLKLLNEK RSELRGIWAE LTHQMQRLRD NPECADQEFE TKKDPNNKGL 

      1030       1040       1050       1060       1070       1080 
STFLTYDVNE DITAPFINKG VKPTIAILRE QGVNSHYEMA AAFDRAGFNA IDVHMSDLMA 

      1090       1100       1110       1120       1130       1140 
GRRNLKDFNA LVACGGFSYG DVLGAGGGWA KSILFNPMLR EQFSQFFANP NTLALGVCNG 

      1150       1160       1170       1180       1190       1200 
CQMVSNLAEI IPGTENWPHF VRNKSERFEA RVGLVKINET NSHWFQGMAG SHMPIAVSHG 

      1210       1220       1230       1240       1250       1260 
EGQVEFKSAQ QLADLTAQKL VIAQYIDNNL QPTEVYPANP NGSVNGITAI SNSDGRVAIM 

      1270       1280       1290 
MPHPERVYRA VSNSWHPEDW TEDGAWMRLF RNARVVLG 

« Hide

References

[1]"Genome and proteome analysis of A. pleuropneumoniae serotype 7."
Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N., Tegetmeyer H., Singh M., Gerlach G.F.
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AP76.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001091 Genomic DNA. Translation: ACE62395.1.
RefSeqYP_001969537.1. NC_010939.1.

3D structure databases

ProteinModelPortalB3H2S8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING537457.APP7_1743.

Protein family/group databases

MEROPSC56.972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACE62395; ACE62395; APP7_1743.
GeneID6396573.
KEGGapa:APP7_1743.
PATRIC20757258. VBIActPle116979_1785.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000261359.
KOK01952.
OMAWPHFVRN.
OrthoDBEOG6FNHHR.
ProtClustDBPRK05297.

Enzyme and pathway databases

BioCycAPLE537457:GJI0-1807-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

Gene3D3.30.1330.10. 2 hits.
HAMAPMF_00419. PurL_1.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB3H2S8_ACTP7
AccessionPrimary (citable) accession number: B3H2S8
Entry history
Integrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)